Actively Recruiting
Study Investigating Anti-drug Antibodies in NSCLC Patients Exposed to Checkpoint Inhibitors (IMB)
Led by Fondazione Ricerca Traslazionale · Updated on 2026-02-06
270
Participants Needed
2
Research Sites
449 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Non-small cell lung cancer (NSCLC) is one of the leading causes of death in Western countries. Today, a new frontier in the fight against cancer is immunotherapy, a treatment that aims to "awaken" the patient's immune system to help it recognize and attack cancer cells. Among the various approaches, there is significant focus on therapies that activate T lymphocytes, a type of immune cell, encouraging them to react against the tumor. These treatments have led to important progress and represent a hope for the future.
CONDITIONS
Official Title
Study Investigating Anti-drug Antibodies in NSCLC Patients Exposed to Checkpoint Inhibitors (IMB)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed diagnosis of NSCLC
- Ability to provide blood samples
- Candidate for treatment with any checkpoint inhibitor (single agent pembrolizumab, atezolizumab, nivolumab, durvalumab, or nivolumab with ipilimumab) in any therapy line
- Performance status 0-2 (ECOG)
- Compliance with trial procedures
- Age 18 years or older
- Signed informed consent
You will not qualify if you...
- Unable to provide blood samples
- Previous treatment with any checkpoint inhibitor
- Candidate for checkpoint inhibitor therapy combined with chemotherapy or non-checkpoint inhibitors
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Istituto Tumori Regina Elena
Roma, RM, Italy, 000144
Enrolling by Invitation
2
Istituto Tumori Regina Elena
Roma, RM, Italy, 00128
Actively Recruiting
Research Team
F
Federico FC Cappuzzo, PI
CONTACT
G
Grisel GM Maver Militello, Monitor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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