Actively Recruiting
A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
Led by Mayo Clinic · Updated on 2025-09-25
70
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to compare the impact of inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) on cardiovascular function in patients with heart failure.
CONDITIONS
Official Title
A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older with heart failure with reduced ejection fraction
- Receiving guideline-directed medical therapy for more than 6 weeks or have contraindications to medical therapy
- New York Heart Association (NYHA) class I to III symptoms
- No hospitalizations in the past 3 months
- Body mass index of 45 kg/m2 or less
- Non-smokers with less than 30 pack years smoking history
- Able to exercise without significant orthopedic or musculoskeletal limitations
You will not qualify if you...
- Sustained ventricular tachycardia or ventricular fibrillation within 21 days before study start
- Second or third degree heart block
- Body mass index greater than 45 kg/m2
- Current smokers or smoking history over 30 pack years
- Pregnant women
- Glomerular filtration rate less than 30 mL/min/1.73m2
- Unable to engage in exercise
- Symptomatic peripheral artery disease
- Asthma with frequent or severe exacerbations or low symptom perception
- Ruptured eardrum or other ear conditions
- History of spontaneous pneumothorax or osteoporosis with rib fractures
- History of lung disease
- Additional exclusions for DEXA scan: recent gastrointestinal contrast or radionuclide use, severe degenerative changes or fractures in measurement areas, inability to remain still for measurement
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
E
Eric Bruhn, M.A
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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