Actively Recruiting
Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
Led by University Hospital, Lille · Updated on 2023-01-27
100
Participants Needed
4
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.
CONDITIONS
Official Title
Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed COPD according GOLD guidelines
- Current or ex-smoker with at least 10 pack-years
- Hospitalized for COPD exacerbation
You will not qualify if you...
- Asthma or cystic fibrosis
- Any other chronic lung disease
- Unhealed solid tumor or tumor not in remission
- Consumption of inhaled drugs
- Women of childbearing potential without effective contraception
- Pregnant or breastfeeding women
- Incapable of giving consent
- Lack of social security coverage
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University hospital of Lille
Lille, France, 59037
Actively Recruiting
2
Roubaix hospital
Roubaix, France, 59100
Actively Recruiting
3
Seclin hospital
Seclin, France, 59113
Not Yet Recruiting
4
Tourcoing hospital
Tourcoing, France, 59200
Actively Recruiting
Research Team
N
Nathalie Bautin, MD
CONTACT
O
Olivier Le Rouzic, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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