Actively Recruiting
Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)
Led by Ichnos Sciences SA · Updated on 2026-04-01
200
Participants Needed
32
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a first-in-human, Phase 1, open-label study that will evaluate safety and anti-myeloma activity of ISB 2001 in participants with relapsed/refractory multiple myeloma (R/R MM).
CONDITIONS
Official Title
Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with pathologically confirmed multiple myeloma with measurable M-protein in serum, urine, or isolated plasmacytoma
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
- Adequate blood, liver, kidney, and heart function
You will not qualify if you...
- Active malignant involvement of the central nervous system
- Uncontrolled infection requiring systemic antibiotics or other serious infection before treatment start
- History of autoimmune disease needing systemic immunosuppressive therapy
- Any uncontrolled medical, psychiatric, or social condition that could interfere with study participation or safety
- Women who are breastfeeding or have a positive pregnancy test at screening or before first dose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
Standford Cancer Institute
Palo Alto, California, United States, 94304
Actively Recruiting
2
Sylvester Cancer Center
Miami, Florida, United States, 33136
Active, Not Recruiting
3
Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
4
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
5
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
6
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
7
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
8
Tennessee Oncology
Nashville, Tennessee, United States, 37203
Active, Not Recruiting
9
Virginia Commonwealth University (VCU)
Richmond, Virginia, United States, 23298
Active, Not Recruiting
10
Froedtert Hospital & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
11
Concord Hospital
Concord, New South Wales, Australia, 2139
Actively Recruiting
12
Pindara Private Hospital
Benowa, Queensland, Australia, 4217
Actively Recruiting
13
St. Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia, 3065
Actively Recruiting
14
Peter MacCallum Cancer Center
Melbourne, Victoria, Australia, 3000
Actively Recruiting
15
Linear Clinical Research
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
16
CHRU Lille
Lille, Hauts-de-France, France, 59800
Actively Recruiting
17
CHU Poiters - Hospital la Miletrie
Poitiers, New Aquitaine, France, 86021
Actively Recruiting
18
CHU de Nantes - Hotel Dieu
Nantes, Pays de la Loire Region, France, 44093
Actively Recruiting
19
Groupe Hospitalier Pitie-Salpetriere
Paris, Île-de-France Region, France, 75013
Actively Recruiting
20
Apollo Hospital International Limited
Gandhinagar, Gujarat, India, 382428
Active, Not Recruiting
21
Health Care Global Enterprises Ltd.
Bangalore, Karnataka, India, 560027
Active, Not Recruiting
22
Deenanath Mangeshkar Hospital and Research Centre
Pune, Maharashta, India, 411004
Active, Not Recruiting
23
Apollo Cancer Centers
Hyderabad, Telangana, India, 500033
Active, Not Recruiting
24
HCG Hospital
Bangalore, India
Active, Not Recruiting
25
ASST Spedali Civili di Brescia
Brescia, Lombardy, Italy, 25123
Active, Not Recruiting
26
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan, Lombardy, Italy, 20122
Actively Recruiting
27
Oslo University Hospital
Oslo, Oslo, Norway, 0372
Actively Recruiting
28
Instituto de Investigacion Biomedica de Salamanca (IBSAL)
Salamanca, Castile de Leon, Spain, 37007
Actively Recruiting
29
Institut Catala de Oncologia (ICO)
Badalona, Catalonia, Spain, 08916
Actively Recruiting
30
Hospital Clinic de Barcelona
Barcelona, Catalonia, Spain, 08036
Actively Recruiting
31
Centro Integral Oncologici Clara Campal
Madrid, Madrid, Spain, 28050
Active, Not Recruiting
32
Clinica Universidad de Nevarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
Research Team
I
Ichnos Sciences Clinical Trials Administrator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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