Actively Recruiting
A Study of Isoquercetin in People With Ovarian Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-16
90
Participants Needed
8
Research Sites
310 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test whether isoquercetin can reduce markers in the blood that may indicate the risk of blood clots in people with ovarian cancer. The effects of isoquercetin will be compared with those of a placebo.
CONDITIONS
Official Title
A Study of Isoquercetin in People With Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have confirmed ovarian cancer (epithelial, serous, or clear cell) and be receiving first-line chemotherapy aligned with isoquercetin start
- Minimum age of 18 years
- Life expectancy greater than 6 months
- ECOG performance status less than 2
- Preserved organ and marrow function as defined by:
- Platelet count over 50,000/mcL
- Prothrombin time (PT) and partial thromboplastin time (PTT) less than 1.5 times institutional upper limit of normal
- Total bilirubin less than 3 times upper limit of normal without liver metastases, less than 5 times with liver metastases
- AST and ALT less than 3 times upper limit of normal without liver metastases, less than 5 times with liver metastases
- Estimated creatinine clearance over 30 ml/min
- Women of child-bearing potential and men must agree to use effective contraception during the study
- Ability to understand and sign informed consent
You will not qualify if you...
- History of venous thromboembolic event within the last 2 years (except central line associated events with completed anticoagulation)
- Active bleeding or high risk for bleeding (e.g., acute gastrointestinal ulcer)
- Significant hemorrhage requiring hospitalization or transfusion outside surgical setting within last 24 months
- Familial bleeding disorders
- Known diagnosis of disseminated intravascular coagulation (DIC)
- Currently receiving anticoagulant therapy
- Daily use of aspirin, clopidogrel, cilostazol, aspirin-dipyridamole within 10 days or regular high-dose NSAIDs use
- Uncontrolled illness including active infection, symptomatic heart failure, unstable angina, arrhythmia, or psychiatric/social issues limiting compliance
- Known intolerance to (iso)quercetin, niacin, or ascorbic acid including G6PD deficiency
- Known brain metastases
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Beth Israel Deaconess Medical Center (Data Collection Only)
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
2
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
3
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
4
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
5
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )
Commack, New York, United States, 11725
Actively Recruiting
6
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, New York, United States, 10065
Actively Recruiting
8
Memorial Sloan Kettering Nassau (All protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
J
Jeffrey Zwicker, MD
CONTACT
E
Elizabeth Jewell, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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