Actively Recruiting
Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer
Led by Janux Therapeutics · Updated on 2026-04-22
43
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a first-in-human, Phase 1, open-label, multicenter study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and the preliminary efficacy of JANX014 in adults with metastatic castration-resistant prostate cancer (mCRPC).
CONDITIONS
Official Title
Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male 18 years of age or older at the time of signing informed consent
- Histologically or cytologically confirmed adenocarcinoma of the prostate
- For Dose Escalation: Metastatic castration-resistant prostate cancer progressed after at least one novel anti-androgen therapy and at least one taxane-containing regimen, or medically unsuitable/refused taxane
- Adequate organ function
- For Dose Expansion: Received 2 or fewer anti-androgen therapies in hormone-sensitive or castration-resistant settings and no more than 1 prior taxane regimen in hormone-sensitive setting, or medically unsuitable/refused taxane
You will not qualify if you...
- Prior solid organ transplant
- Prior treatment with any CAR-T cell therapy, approved or investigational T-cell engager therapy, or prior radioligand therapy
- Clinically significant cardiovascular disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
Research Team
J
Janux Therapeutics, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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