Actively Recruiting
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Led by Johnson & Johnson Enterprise Innovation Inc. · Updated on 2026-05-11
130
Participants Needed
41
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether JNJ-90301900 added to concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation immunotherapy (cIT) can improve objective response rate (ORR; that is percentage of participants whose best response is complete response or partial response during the study) in participants with locally advanced and unresectable stage III non-small cell lung cancer.
CONDITIONS
Official Title
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be a candidate for standard concurrent platinum-based doublet chemotherapy with radiation followed by consolidation durvalumab as determined by investigator and local guidelines
- Have a pathologically confirmed diagnosis of NSCLC within 3 months before enrollment
- Have locally advanced unresectable stage III NSCLC per the eighth edition lung cancer staging
- Have at least one target lesion suitable for intratumoral and/or intranodal injection and intensity modulated radiation therapy
- Have an ECOG performance status of 0 to 1
You will not qualify if you...
- History of primary immunodeficiency or organ transplant requiring immunosuppression
- Severe or unstable angina, myocardial infarction, significant arrhythmias, or heart failure class III-IV within 3 months before enrollment
- Another concurrent or prior primary malignancy within 36 months before informed consent
- Known allergies or intolerance to JNJ-90301900, platinum-based chemotherapy, or durvalumab
- History of coagulation disorders including active bleeding or major thromboembolic events within 3 months before enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 41 locations
1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030
Actively Recruiting
2
Yale University
New Haven, Connecticut, United States, 06519
Actively Recruiting
3
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
4
Orlando Health Cancer Institute
Orlando, Florida, United States, 32806
Actively Recruiting
5
Emory University Winship Cancer Institute
Atlanta, Georgia, United States, 30306
Actively Recruiting
6
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
7
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
8
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
9
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
10
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
11
FirstHealth of the Carolinas
Pinehurst, North Carolina, United States, 28374
Actively Recruiting
12
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
13
Oregon Health And Science University
Portland, Oregon, United States, 97239
Actively Recruiting
14
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
15
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
16
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
17
Royal Brisbane and Women's Hospital
Herston, Australia, 4029
Actively Recruiting
18
Sir Charles Gairdner Hospital
Nedlands, Australia, 6009
Actively Recruiting
19
Macquarie University
North Ryde, Australia, 2109
Actively Recruiting
20
Royal Melbourne Hospital
Parkville, Australia, 3050
Actively Recruiting
21
Fundacao Pio XII
Barretos, Brazil, 14784 400
Actively Recruiting
22
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
São Paulo, Brazil, 01308 050
Actively Recruiting
23
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, Brazil, 05651 901
Actively Recruiting
24
Dongguan People s Hospital
Dongguan, China, 523109
Actively Recruiting
25
The First Affiliated Hospital Sun Yat sen University
Guangzhou, China, 510080
Actively Recruiting
26
The Affiliated Cancer Hospital of Shandong First Medical University
Jinan, China, 250117
Actively Recruiting
27
Hopital De La Cavale Blanche
Brest, France, 29200
Actively Recruiting
28
Hopital Nord Marseille
Marseille, France, 13015
Actively Recruiting
29
Hopital Tenon
Paris, France, 75020
Actively Recruiting
30
Institut Curie
Paris, France, 75248
Actively Recruiting
31
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
32
Prince of Wales Hospital
Shatin, Hong Kong
Actively Recruiting
33
Antoni van Leeuwenhoek
Amsterdam, Netherlands, 1066 CX
Actively Recruiting
34
Radboud Umcn
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
35
Hosp. Univ. 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
36
Clinica Univ. de Navarra
Pamplona, Spain, 31008
Actively Recruiting
37
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, Spain, 15706
Actively Recruiting
38
Hosp. Univ. I Politecni La Fe
Valencia, Spain, 46026
Actively Recruiting
39
Marmara University Pendik Training Hospital
Istanbul, Turkey (Türkiye), 34899
Actively Recruiting
40
Sakarya University Training and Research Hospital
Sakarya, Turkey (Türkiye), 54100
Actively Recruiting
41
University College London Hospitals
London, United Kingdom, NW1 2BU
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here