Actively Recruiting
Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracture
Led by Peking Union Medical College Hospital · Updated on 2026-01-12
2478
Participants Needed
58
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project anchors osteoporotic fractures, conduct registration and follow-up studies, and conduct prospective treatment studies. By registering for follow-up studies on osteoporotic fractures, it is planned to obtain epidemiological data through registration and follow-up studies; A prospective treatment study for patients with osteoporotic fractures is planned to explore effective treatment strategies through randomized controlled trials; To study biomarkers for osteoporotic refractures, we plan to establish a biomarker warning model through multi omics research; To study imaging biomarkers for osteoporotic refractures, a new imaging technology is proposed to establish an imaging omics warning model.
CONDITIONS
Official Title
Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracture
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New brittle hip fractures
- New brittle vertebral fractures
- New fractures at other sites and/or total hip or neck of femur or L1-L4 T-value < -1.0
- Men or postmenopausal women
- Age between 45 and 90 years old
- Ability to move independently
You will not qualify if you...
- Bone metabolic diseases other than osteoporosis (e.g., Osteogenesis Imperfecta, Paget's disease, Osteomalacia), Cushing's syndrome, hyperprolactinemia
- Primary hyperparathyroidism or hypothyroidism
- History or presence of osteomyelitis or necrosis of the jaw
- Glomerular filtration rate (GFR) less than 30 ml/min/1.73m2
- Active infections requiring systemic treatment
- Use of intravenous bisphosphonate, fluoride, or strontium for osteoporosis within 2 years
- Use of teriparatide or denosumab for osteoporosis within 6 months
- Use of glucocorticoids equivalent to more than 5 mg/day prednisone for over 10 days within 6 weeks
- Oral bisphosphonate use less than 1 year apart (with exceptions if cumulative use ≤ 1 month)
- History of malignant tumors or bone metastases within 5 years, except cured tumors
- Presence of hypocalcemia or hypercalcemia
- Unexplained elevation of alkaline phosphatase
- Severe vitamin D deficiency (25OHD <10 ng/mL)
- Previous external radiation or radiation therapy with bone implants
- Uncontrolled comorbidities including advanced heart failure, high glycosylated hemoglobin (>8.5%), or severe arrhythmias
- Current pregnancy or lactation
- Allergy to teriparatide or denosumab
- Participation in other drug clinical trials
- Unsuitability for the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 58 locations
1
Beijing Friendship Hospital, Capital Medical University
Beijing, China
Actively Recruiting
2
Beijing Hospital
Beijing, China
Actively Recruiting
3
Beijing Pinggu Hospital
Beijing, China
Actively Recruiting
4
Beijing Shijingshan Hospital
Beijing, China
Actively Recruiting
5
Beijing Yanhua Hospital
Beijing, China
Actively Recruiting
6
Peking Union Medical College Hospital
Beijing, China
Actively Recruiting
7
Peking University Third Hospital
Beijing, China
Actively Recruiting
8
Jilin Province FAW General Hospital
Changchun, China
Actively Recruiting
9
The Second XIANGYA Hospital of Central South University
Changsha, China
Actively Recruiting
10
Changzhou NO.2 People&#39;s Hospital
Changzhou, China
Actively Recruiting
11
The First People&#39;s Hospital of Changzhou
Changzhou, China
Actively Recruiting
12
Sichuan Provincial People's Hospital
Chengdu, China
Actively Recruiting
13
West China Fourth Hospital of Sichuan University
Chengdu, China
Actively Recruiting
14
The Second People&#39;s Hospital of Dalian
Dalian, China
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15
Shengli Oilfield Central Hospital
Dongying, China
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16
Affiliated Hospital of Guizhou Medical University
Guiyang, China
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17
Zhejiang Provincial People&#39;s Hospital Bijie Hospital
Guizhou, China
Actively Recruiting
18
The Fourth Hospital of Harbin Medical University
Haerbin, China
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19
The Second Hospital of Jilin University
Haerbin, China
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20
Zhejiang Provincial People&#39;s Hospital
Hangzhou, China
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21
The First Affiliated Hospital of Anhui Medical University
Hefei, China
Actively Recruiting
22
The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Hefei, China
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23
Affiliated Hospital of Inner Mongolia Medical University
Hohhot, China
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24
Shandong Provincial Hospital
Jinan, China
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25
The Second Hospital of Shandong University
Jinan, China
Actively Recruiting
26
Affiliated Hospital of Jining Medical University
Jining, China
Actively Recruiting
27
Gansu Provincial Hospital
Lanzhou, China
Actively Recruiting
28
Liaocheng People&#39;s Hospital
Liaocheng, China
Actively Recruiting
29
Jiangxi Provincial People&#39;s Hospital
Nanchang, China
Actively Recruiting
30
Zhongda Hospital Southeast University
Nanjing, China
Actively Recruiting
31
Ningbo NO.2 Hospital
Ningbo, China
Actively Recruiting
32
Qingdao Municipal Hospital
Qingdao, China
Actively Recruiting
33
Changhai Hospital
Shanghai, China
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34
Huadong Hospital Affiliated to Fudan University
Shanghai, China
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35
Shanghai Changzheng Hospital
Shanghai, China
Actively Recruiting
36
Shanghai General Hospital
Shanghai, China
Actively Recruiting
37
Shanghai Sixth People&#39;s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
Actively Recruiting
38
Tongji Hospital of Tongji University
Shanghai, China
Actively Recruiting
39
Huazhong University of Science and Technology Union Shenzhen Hospital
Shenzhen, China
Actively Recruiting
40
Shenzhen Shiyan People&#39;s Hospital
Shenzhen, China
Actively Recruiting
41
The Seventh Affiliated Hospital of Sun Yat-sen University
Shenzhen, China
Actively Recruiting
42
Hebei Medical University Third Hospital
Shijiazhuang, China
Actively Recruiting
43
Kunshan Hospital of Traditional Chinese Medicine
Suzhou, China
Actively Recruiting
44
The First People&#39;s Hospital of Kunshan
Suzhou, China
Actively Recruiting
45
The Second Affiliated Hospital of Soochow University
Suzhou, China
Actively Recruiting
46
First Hospital of Shanxi Medical University
Taiyuan, China
Actively Recruiting
47
Second Hospital of Shanxi Medical University
Taiyuan, China
Actively Recruiting
48
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, China
Actively Recruiting
49
Weifang People&#39;s Hospital
Weifang, China
Actively Recruiting
50
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Actively Recruiting
51
Qinghai University Affiliated Hospital
Xining, China
Actively Recruiting
52
General Hospital of Ningxia Medical University
Yinchuan, China
Actively Recruiting
53
People&#39;s Hospital of Ningxia Hui Autonomous Region
Yinchuan, China
Actively Recruiting
54
Henan Provincial General Hospital
Zhengzhou, China
Actively Recruiting
55
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Actively Recruiting
56
The Fifth Affiliated Hospital Sun Yat-sen University
Zhuhai, China
Actively Recruiting
57
PKUCare Luzhong Hospital
Zibo, China
Actively Recruiting
58
Zibo Central Hospital
Zibo, China
Actively Recruiting
Research Team
W
Weibo Xia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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