Actively Recruiting
A Study of LAD191 in Adults With Hidradenitis Suppurativa
Led by Almirall, S.A. · Updated on 2026-05-11
200
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to assess the efficacy of multiple dosing regimens of LAD191 compared to placebo in participants with moderate-to-severe Hidradenitis Suppurativa (HS) and to access the safety, tolerability, pharmacokinetic and immunogenicity in participants with moderate-to-severe HS.
CONDITIONS
Official Title
A Study of LAD191 in Adults With Hidradenitis Suppurativa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 65 years
- Diagnosed with moderate-to-severe Hidradenitis Suppurativa with at least 5 inflammatory lesions at screening and baseline
- HS lesions present in at least two different body areas, with one area at Hurley Stage II or III
- History of inadequate response, intolerance, or contraindication to systemic antibiotics for HS
- Regular use of over-the-counter topical antiseptics on HS lesions and agreement to continue throughout the study
- Women of child-bearing potential and male participants agree to pregnancy avoidance requirements during the study
You will not qualify if you...
- More than 20 draining tunnels at screening or baseline
- Ongoing medical conditions requiring systemic immunosuppressive or immunomodulating treatments
- Known allergy to LAD191 or its components
- Known allergy or contraindication to adalimumab or biosimilar products
- Significant hypersensitivity to prior biologic therapies
- Prior treatment with LAD191
- Live or attenuated vaccinations within 4 weeks before baseline or planned during the study
- Pregnant or breastfeeding women or planning pregnancy or breastfeeding during the study
- Use of prohibited medications or therapies without required washout before baseline
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hospital de Manises
Manises, Spain, 46940
Actively Recruiting
Research Team
V
Victor Castellano
CONTACT
E
Estrella García
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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