Actively Recruiting
A Study of LAD603 in Adults With Alopecia Areata
Led by Almirall, S.A. · Updated on 2026-01-12
136
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main aim of the study is to evaluate the effect of LAD603 in adult participants with severe to very severe alopecia areata (AA). The study will also evaluate the safety, pharmacokinetics (PK), immunogenicity and pharmacodynamic (PD) biomarkers of LAD603.
CONDITIONS
Official Title
A Study of LAD603 in Adults With Alopecia Areata
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female between 18 and 65 years old at informed consent
- Severe to very severe alopecia areata with 50% or more scalp hair loss measured by SALT, without terminal hair regrowth within 6 months at screening and baseline
- Current hair loss episode lasting at least 6 months but no longer than 7 years
- Agreement to pregnancy avoidance if female of childbearing potential or male participant
You will not qualify if you...
- Other types of alopecia such as traction or scarring alopecia
- Diffuse alopecia areata
- Active inflammatory skin diseases like psoriasis, seborrheic dermatitis, or lupus interfering with alopecia assessment
- Previous severe reaction to subcutaneous medication
- Elevated liver enzymes (ALT or AST ≥ 2.5 × ULN)
- Total bilirubin ≥ 1.5 × ULN (≥ 3 × ULN if Gilbert's syndrome)
- Alkaline phosphatase ≥ 1.5 × ULN
- Use of prohibited medications or failure to complete required washout periods
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Investigator Site 1
Omaha, Nebraska, United States, 68144
Actively Recruiting
Research Team
D
Davide Carluccio
CONTACT
E
Estrella García
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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