Study of Late-foetal Human Organ Development

What this Trial Is About

Understanding abnormal organ development is crucial for improving knowledge of congenital and acquired diseases and for developing new treatments. Most current insights come from examining tissues from early pregnancy terminations, but little is known about organ development during the last two-thirds of pregnancy, a key period when fetal tissue remodeling occurs. This study aims to collect tissue samples from various fetal organs during this late stage of pregnancy from women undergoing termination who agree to a fetal postmortem examination. The study is observational and focuses on collecting and analyzing fetal tissue samples. There are no interventions or treatments being tested. The tissue collection occurs after termination of pregnancy during a clinical fetal postmortem examination. The main focus is on assessing cellular maturity immediately after tissue collection to better understand late fetal organ development. Participants will be pregnant women aged 18 years or older who decide to terminate their pregnancy due to fetal abnormalities and consent to postmortem tissue collection. Researchers will gather tissue samples and analyze cellular maturity. Safety and ethical considerations include the consent process and screening for infections. The study will continue until December 31, 2040, with data collected and analyzed to advance knowledge of fetal organ development.

Study of Late-foetal Human Organ Development