Actively Recruiting
A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-06-11
37
Participants Needed
3
Research Sites
236 weeks
Total Duration
On this page
Sponsors
U
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor
N
Nanjing Legend Biotech Co.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective, single-arm, open-label, dose-exploration and expansion clinical study of LCAR-AIO in adult subjects with relapsed/refractory neurological autoimmune diseases.
CONDITIONS
Official Title
A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily agree to participate in clinical research
- Age between 18 and 70 years
- Have adequate organ function at screening
- Meet clinical laboratory criteria at screening visit
- Diagnosed with Multiple Sclerosis at least 6 months before screening and have relapsed/refractory MS
- Diagnosed with NMOSD or MOGAD at least 6 months before screening
- Positive for AQP-4 IgG (NMOSD) or MOG-IgG (MOGAD) by cell-based assay
- Have relapsed/refractory NMOSD or MOGAD
- Diagnosed with Myasthenia Gravis at least 6 months before screening
- Positive for AChR-IgG or MuSK-IgG
- Have relapsed/refractory Myasthenia Gravis
You will not qualify if you...
- Have active infections such as hepatitis or tuberculosis
- Have other autoimmune diseases
- Have serious underlying diseases such as tumors, uncontrolled diabetes, or significant cardiovascular disease
- Are pregnant, breastfeeding, or planning to become pregnant during the study or within one year after LCAR-AIO treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
The Affiliated Hospital of Fujian Medical University
Fuzhou, China
Not Yet Recruiting
2
The First Affiliated Hospital of SOOCHOW University
Suzhou, China
Actively Recruiting
3
Union Hospital Tongji Medical College HUAZHONG University of Science and Technology
Wuhan, China
Actively Recruiting
Research Team
Q
Qiubai li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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