Actively Recruiting
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
Led by Pfizer · Updated on 2026-04-23
20
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity. Participants will receive the study medicine for a short period, and doctors will measure how the medicine moves through the stomach and monitor safety. The goal is to better understand how this medicine works in the body and to check for any side effects. The information from this study may help researchers plan future studies of this medicine.
CONDITIONS
Official Title
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older, male or female, generally healthy based on medical history, physical exam, lab tests, and ECG
- Body mass index (BMI) between 27 and 45 kg/m²
- Body weight greater than 50 kg (110 lb)
- Participants must have overweight or obesity
You will not qualify if you...
- History or presence of significant medical conditions including cardiovascular, liver, kidney, lung, endocrine, blood, neurological, gastrointestinal (including pancreatitis or gallbladder disease), or major psychiatric disorders
- Any form of diabetes, HbA1c 6.5% or higher, or fasting plasma glucose 126 mg/dL or higher
- Prior use of a GLP-1 receptor agonist within 90 days before the first dose
- Previous participation in a study with PF-08653944
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pfizer Clinical Research Unit - New Haven
New Haven, Connecticut, United States, 06511
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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