Actively Recruiting
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Led by Pfizer · Updated on 2026-05-12
982
Participants Needed
129
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
CONDITIONS
Official Title
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Active diagnosis of metastatic pancreatic ductal adenocarcinoma
- Cachexia defined by weight loss according to Fearon criteria
- Completed 1 cycle (28 days) of nab-paclitaxel and gemcitabine chemotherapy or 2 cycles (14 days each) of FOLFIRINOX chemotherapy before starting Cycle 2 chemotherapy
- ECOG performance status of 0 or 1 with life expectancy of at least 4 months
You will not qualify if you...
- Active reversible causes of decreased food intake
- Cachexia caused by reasons other than pancreatic cancer
- Any past or current diagnosis of heart failure
- Left ventricular ejection fraction less than 50%
- Receiving tube feedings or parenteral nutrition at screening or randomization
- History of allergic or anaphylactic reaction to any monoclonal antibody
- Allergy or hypersensitivity to any chemotherapy drugs or their components
- Neuroendocrine or acinar pancreatic carcinoma, symptomatic brain or central nervous system metastases
- Inadequate liver function
- Renal disease requiring dialysis or estimated glomerular filtration rate below 30 mL/min/1.73m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 129 locations
1
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States, 35233
Not Yet Recruiting
2
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Not Yet Recruiting
3
Central Arkansas Radiation Therapy Institute, dba CARTI
Bryant, Arkansas, United States, 72022
Not Yet Recruiting
4
Central Arkansas Radiation Therapy Institute, dba CARTI
Conway, Arkansas, United States, 72034
Not Yet Recruiting
5
CARTI Cancer Center
Little Rock, Arkansas, United States, 72205
Not Yet Recruiting
6
Central Arkansas Radiation Therapy Institute, dba CARTI
North Little Rock, Arkansas, United States, 72117
Not Yet Recruiting
7
Central Arkansas Radiation Therapy Institute, dba CARTI
Pine Bluff, Arkansas, United States, 71603
Not Yet Recruiting
8
Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States, 92612
Not Yet Recruiting
9
UCI Health - Irvine
Irvine, California, United States, 92612
Not Yet Recruiting
10
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
11
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States, 90095
Not Yet Recruiting
12
UC Irvine Health
Orange, California, United States, 92868
Not Yet Recruiting
13
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States, 90404
Not Yet Recruiting
14
Providence Medical Foundation
Santa Rosa, California, United States, 95403
Not Yet Recruiting
15
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
Washington D.C., District of Columbia, United States, 20007
Not Yet Recruiting
16
Georgetown University Medical Center
Washington D.C., District of Columbia, United States, 20007
Not Yet Recruiting
17
University Cancer & Blood Center, LLC
Athens, Georgia, United States, 30607
Actively Recruiting
18
Invision, LLC
Honolulu, Hawaii, United States, 96813
Actively Recruiting
19
University of Hawaii Cancer Center
Honolulu, Hawaii, United States, 96813
Actively Recruiting
20
Cardiology Associates, Inc
‘Aiea, Hawaii, United States, 96701
Actively Recruiting
21
Cancer Care Specialists of Illinois
Decatur, Illinois, United States, 62526
Actively Recruiting
22
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
23
Hope and Healing Cancer Services
Hinsdale, Illinois, United States, 60521
Actively Recruiting
24
Hope and Healing Cancer Services New Lenox
New Lenox, Illinois, United States, 60451
Actively Recruiting
25
Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States, 62269
Actively Recruiting
26
University of Kentucky Research Foundation
Lexington, Kentucky, United States, 40506
Not Yet Recruiting
27
University of Kentucky Healthcare - Markey Cancer Center
Lexington, Kentucky, United States, 40536
Not Yet Recruiting
28
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536
Not Yet Recruiting
29
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
Lexington, Kentucky, United States, 40536
Not Yet Recruiting
30
JHU Oncology Central Kit Services
Baltimore, Maryland, United States, 21205
Not Yet Recruiting
31
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
32
Oncology Investigational Drug Service (IDS)
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
33
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
34
Nebraska Medicine
Omaha, Nebraska, United States, 68105
Not Yet Recruiting
35
Nebraska Medicine - Village Pointe
Omaha, Nebraska, United States, 68118
Not Yet Recruiting
36
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Not Yet Recruiting
37
Renown Health Medical Oncology
Reno, Nevada, United States, 89502
Actively Recruiting
38
Renown Office of Clinical Research
Reno, Nevada, United States, 89502
Actively Recruiting
39
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
40
University of Rochester Medical Center
Rochester, New York, United States, 14642
Not Yet Recruiting
41
UNC Hospitals, The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Not Yet Recruiting
42
University of North Carolina Hospitals at Hillsborough
Hillsborough, North Carolina, United States, 27278
Not Yet Recruiting
43
OHSU Center for Health & Healing 1
Portland, Oregon, United States, 97239
Not Yet Recruiting
44
Oregon Health and Science University
Portland, Oregon, United States, 97239
Not Yet Recruiting
45
OSHU Center for Health and Healing 2
Portland, Oregon, United States, 97239
Not Yet Recruiting
46
Houston Methodist Hospital
Houston, Texas, United States, 77030
Not Yet Recruiting
47
Baylor Scott & White Vasicek Cancer Treatment Center
Temple, Texas, United States, 76508
Not Yet Recruiting
48
Virginia Mason Medical Center
Seattle, Washington, United States, 98101
Actively Recruiting
49
Shoalhaven District Memorial Hospital
Nowra, New South Wales, Australia, 2541
Not Yet Recruiting
50
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Not Yet Recruiting
51
ICON Cancer Centre - Kurralta Park
Kurralta Park, South Australia, Australia, 5037
Not Yet Recruiting
52
Icon Cancer Centre Hobart
Hobart, Tasmania, Australia, 7000
Actively Recruiting
53
Western Health-Sunshine & Footscray Hospitals
St Albans, Victoria, Australia, 3021
Not Yet Recruiting
54
Hospital Santa Rita de Cassia
Vitória, Espírito Santo, Brazil, 29041-295
Actively Recruiting
55
Oncocentro
Belo Horizonte, Minas Gerais, Brazil, 30.360-680
Not Yet Recruiting
56
Liga Norte Riograndense Contra o Câncer
Natal, Rio Grande do Norte, Brazil, 59062-000
Not Yet Recruiting
57
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, Brazil, 90560032
Not Yet Recruiting
58
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil, 01246-000
Not Yet Recruiting
59
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Not Yet Recruiting
60
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, Canada, G7H 5H6
Actively Recruiting
61
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
Greenfield Park, Quebec, Canada, J4V 2H1
Actively Recruiting
62
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Not Yet Recruiting
63
Cancer Hospital Chinese Academy of Medical Science
Beijing, Beijing Municipality, China, 100021
Not Yet Recruiting
64
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Not Yet Recruiting
65
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Actively Recruiting
66
Second Hospital of Lanzhou University
Lanzhou, Gansu, China, 730030
Not Yet Recruiting
67
Guangdong General Hospital
Guangzhou, Guangdong, China, 510080
Not Yet Recruiting
68
The University of Hong Kong-Shenzhen Hospital
Shenzhen, Guangdong, China, 518053
Actively Recruiting
69
Affiliated Hospital of Hebei University
Baoding, Hebei, China, 071000
Not Yet Recruiting
70
Cancer Hospital Chinese Academy of Medical Science
Langfang, Hebei, China, 065001
Not Yet Recruiting
71
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
72
The Second Hospital of Dalian Medical University
Dalian, Liaoning, China, 116004
Not Yet Recruiting
73
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Actively Recruiting
74
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Actively Recruiting
75
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
76
The First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China, 030001
Not Yet Recruiting
77
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310015
Not Yet Recruiting
78
Huzhou Central Hospital
Huzhou, Zhejiang, China, 313000
Not Yet Recruiting
79
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
80
Beijing Tsinghua Changgung Hospital
Beijing, China, 102218
Not Yet Recruiting
81
Shanghai General Hospital
Shanghai, China, 200080
Not Yet Recruiting
82
Tata Memorial Hospital
Mumbai, Maharashtra, India, 400012
Actively Recruiting
83
Venkateshwar Hospital
New Delhi, National Capital Territory of Delhi, India, 110075
Not Yet Recruiting
84
Rajiv Gandhi Cancer Institute And Research Centre
New Delhi, National Capital Territory of Delhi, India, 110085
Actively Recruiting
85
Sawai Man Singh Medical College Hospital (SMS Hospital)
Jaipur, Rajasthan, India, 302004
Not Yet Recruiting
86
Chittaranjan National Cancer Institute
Kolkata, West Bengal, India, 700160
Not Yet Recruiting
87
Rabin Medical Center
Petah Tikva, Central District, Israel, 4941492
Actively Recruiting
88
Sheba Medical Center
Ramat Gan, Central District, Israel, 5265601
Actively Recruiting
89
Rambam Health Care Campus
Haifa, Heifa, Israel, 3109601
Actively Recruiting
90
Shaare Zedek Medical Center
Jerusalem, Jerusalem, Israel, 9103102
Actively Recruiting
91
Hadassah Medical Center
Jerusalem, Jerusalem, Israel, 9112001
Actively Recruiting
92
Sourasky Medical Center
Tel Aviv, TELL ABĪB, Israel, 6423906
Actively Recruiting
93
Aichi Cancer Center Hospital
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
94
Chiba cancer center
Chiba, Chiba, Japan, 260-8717
Actively Recruiting
95
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Actively Recruiting
96
Kagawa University Hospital
Kita-gun, Kagawa-ken, Japan, 761-0793
Actively Recruiting
97
St. Marianna University Hospital
Kawasaki, Kanagawa, Japan, 216-8511
Actively Recruiting
98
Kanagawa cancer center
Yokohama, Kanagawa, Japan, 2418515
Actively Recruiting
99
The University of Osaka Hospital
Suita, Osaka, Japan, 565-0871
Actively Recruiting
100
Shizuoka Cancer Center
Nagaizumi-cho, Shizuoka, Japan, 411-8777
Actively Recruiting
101
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan, 104-0045
Actively Recruiting
102
The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan, 135-8550
Actively Recruiting
103
Wakayama Minami Radiology Clinic
Wakayama-shi Kimiidera 870-2, Wakayama, Japan, 641-0012
Actively Recruiting
104
Yamaguchi University Hospital
Ube, Yamaguchi, Japan, 755-8505
Actively Recruiting
105
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan, 811-1395
Actively Recruiting
106
Kyushu University Hospital
Fukuoka, Japan, 812-8582
Actively Recruiting
107
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, Japan, 602-8566
Actively Recruiting
108
Wakayama Medical University Hospital
Wakayama, Japan, 641-8510
Actively Recruiting
109
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, Oaxaca, Mexico, 68020
Not Yet Recruiting
110
Centro de Atención e Investigación Cardiovascular del Potosí S.C.
San Luis Potosí City, Mexico, 78200
Not Yet Recruiting
111
Pan American Center for Oncology Trials, LLC - Dorado Office
Dorado, Puerto Rico, 00646
Actively Recruiting
112
Pan American Center for Oncology Trials, LLC - Mayaguez Office
Mayagüez, Puerto Rico, 00680
Actively Recruiting
113
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico, 00935
Actively Recruiting
114
Pan American Center for Oncology Trials, LLC
San Juan, Puerto Rico, 00909
Actively Recruiting
115
Inha University Hospital
Incheon, Incheon-gwangyeoksi [incheon], South Korea, 22332
Actively Recruiting
116
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea, 13620
Actively Recruiting
117
CHA Bundang Medical Center, CHA University
Seongnam-si, Kyǒnggi-do, South Korea, 13496
Actively Recruiting
118
Asan Medical Center
Seoul, Seoul Teukbyeolsi, South Korea, 05505
Actively Recruiting
119
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03080
Actively Recruiting
120
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722
Actively Recruiting
121
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06351
Actively Recruiting
122
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06591
Actively Recruiting
123
Keimyung University Dongsan Hospital
Daegu, Taegu-kwangyǒkshi, South Korea, 42601
Actively Recruiting
124
Inje University Haeundae Paik Hospital
Busan, South Korea, 48108
Actively Recruiting
125
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807
Actively Recruiting
126
China Medical University Hospital
Taichung, Taiwan, 404332
Actively Recruiting
127
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
128
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
129
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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