Actively Recruiting
A Phase 2 Randomized, Double-Blind Study Evaluating Safety, Tolerability, and Immune Response of mRNA Influenza Vaccines in Adults 18 and Older
Led by Pfizer · Updated on 2026-05-06
770
Participants Needed
15
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and immune response of several mRNA-based influenza vaccines in healthy adults aged 18 years and older. This Phase 2, randomized, double-blind study compares six investigational mRNA flu vaccines against licensed influenza vaccines. The goal is to understand how well these vaccines stimulate the body's defense against the flu virus and to monitor any side effects. Participants will receive one single dose of either one of the six mRNA influenza vaccine candidates or one of the licensed flu vaccines by intramuscular injection on Day 1. The study includes one treatment period where the vaccines are administered, and the participants will be monitored for reactions and immune responses over time. Participants will visit the study site at least three times over approximately six months. At each visit, blood samples will be collected to measure antibody levels, and a nasal swab will be taken at the first visit. Researchers will track local and systemic reactions within 7 days of vaccination, as well as adverse events, serious adverse events, and any new chronic medical conditions for up to six months. The study aims to assess the immune response and safety profile of the vaccines during this period.
CONDITIONS
Brief Title
A Study to Learn About mRNA Vaccines Against Influenza in Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy and medically stable adults aged 18 years or older
- Eligible based on medical history, physical exam if required, and investigator judgment
You will not qualify if you...
- Tested positive for influenza within 5 months prior to study start
- Received any investigational or licensed influenza vaccine within 5 months prior to study start
- Taken antiviral treatments for influenza, such as Tamiflu, within 5 months prior to study start
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants receive a single intramuscular injection of one of the mRNA influenza vaccine candidates or a licensed influenza vaccine.
1 vaccination visit (in-person)
Duration - 6 months
Participants are monitored for safety, tolerability, and immune response after vaccination.
Multiple follow-up visits within 7 days, 1 month, 4 weeks, and up to 6 months after vaccination
Trial Site Locations
Total: 15 locations
1
AMR Clinical
Mobile, Alabama, United States, 36608
Actively Recruiting
2
Diablo Clinical Research, LLC d/b/a Flourish Research
Walnut Creek, California, United States, 94598
Actively Recruiting
3
Clinical Research Consulting, LLC
Milford, Connecticut, United States, 06460
Actively Recruiting
4
George Washington Medical Faculty Associates
Washington D.C., District of Columbia, United States, 20037
Actively Recruiting
5
Indago Research & Health Center, Inc
Hialeah, Florida, United States, 33012
Actively Recruiting
6
Palm Springs Community Health Center
Miami Lakes, Florida, United States, 33014
Actively Recruiting
7
Clinical Research Atlanta
Stockbridge, Georgia, United States, 30281
Actively Recruiting
8
East-West Medical Research Institute
Honolulu, Hawaii, United States, 96814
Actively Recruiting
9
AMR Clinical
Kansas City, Missouri, United States, 64114
Actively Recruiting
10
Rochester Clinical Research, LLC
Rochester, New York, United States, 14609
Actively Recruiting
11
DM Clinical Research - Philadelphia
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
12
SMS Clinical Research LLC
Mesquite, Texas, United States, 75149
Actively Recruiting
13
DM Clinical Research
Tomball, Texas, United States, 77375
Actively Recruiting
14
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, United States, 84109
Actively Recruiting
15
Charlottesville Medical Research Center, LLC
Charlottesville, Virginia, United States, 22911
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
7
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