Actively Recruiting
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
Led by Alterome Therapeutics, Inc. · Updated on 2026-03-09
110
Participants Needed
51
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to characterize the safety and tolerability of ALTA2618 in adults with AKT1 E17K-mutant advanced solid tumors.
CONDITIONS
Official Title
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed solid tumor with AKT1 E17K mutation using certified molecular testing
- Unresectable or metastatic disease
- Progressed on, intolerant to, or declined prior standard therapies suitable for tumor type and stage
- Measurable or evaluable disease by RECIST v1.1
- ECOG performance status of 0 or 1
- Adequate organ function
You will not qualify if you...
- Previous treatment with PI3K or mTOR inhibitors
- Known tumor mutations in KRAS, NRAS, HRAS, or BRAF
- Conditions preventing swallowing or absorption of oral medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 51 locations
1
Research Site
La Jolla, California, United States, 92093
Actively Recruiting
2
Research Site
Los Angeles, California, United States, 90095
Actively Recruiting
3
Research Site
Denver, Colorado, United States, 80218
Actively Recruiting
4
Research Site
Sarasota, Florida, United States, 34232
Actively Recruiting
5
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
6
Research Site
Boston, Massachusetts, United States, 02114
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7
Research Site
Boston, Massachusetts, United States, 02215
Actively Recruiting
8
Research Site
St Louis, Missouri, United States, 63110
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9
Research Site
Mineola, New York, United States, 11501
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10
Research Site
New York, New York, United States, 10016
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11
Research Site
Maumee, Ohio, United States, 43637
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12
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
13
Research Site
Dallas, Texas, United States, 75230
Withdrawn
14
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
15
Research Site #2
San Antonio, Texas, United States, 78229
Actively Recruiting
16
Research Site
San Antonio, Texas, United States, 78229
Actively Recruiting
17
Research Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
18
Research Site
Madison, Wisconsin, United States, 53792
Actively Recruiting
19
Research Site
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
20
Research Site
Randwick, New South Wales, Australia, 2031
Actively Recruiting
21
Research Site
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
22
Research Site
Malvern, Victoria, Australia, 3144
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23
Research Site
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
24
Research Site
Caen, France, 14000
Actively Recruiting
25
Research Site
Dijon, France, 21000
Actively Recruiting
26
Research Site
Saint-Herblain, France, 44805
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27
Research Site
Villejuif, France, 94800
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28
Research Site
Kyoto, Japan, 606-8507
Actively Recruiting
29
Research Site
Matsuyama, Japan, 791-0280
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30
Research Site
Shizuoka, Japan, 411-8777
Actively Recruiting
31
Research Site
Tokyo, Japan, 135-8550
Actively Recruiting
32
Research Site
Seoul, South Korea, 03722
Actively Recruiting
33
Research Site
Seoul, South Korea, 05505
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34
Research Site
Seoul, South Korea, 06351
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35
Research Site
Seoul, South Korea, 06591
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36
Research Site
Seoul, South Korea, 13620
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37
Research Site
Barcelona, Spain, 08023
Actively Recruiting
38
Research Site
Barcelona, Spain, 08035
Actively Recruiting
39
Research Site
Barcelona, Spain, 08908
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40
Research Site
Madrid, Spain, 28023
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41
Research Site
Madrid, Spain, 28040
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42
Research Site
Valencia, Spain, 46010
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43
Research Site
Changhua, Taiwan, 500
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44
Research Site
Taipei, Taiwan, 100
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45
Research Site
Taipei, Taiwan, 10449
Actively Recruiting
46
Research Site
London, United Kingdom, SW3 6JJ
Actively Recruiting
47
Research Site
London, United Kingdom, W1G 6AD
Actively Recruiting
48
Research Site
London, United Kingdom, W1T 7HA
Actively Recruiting
49
Research Site
Manchester, United Kingdom, M10 4BX
Actively Recruiting
50
Research Site
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
51
Research Site
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
A
Alterome Clinical Trial Contact Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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