Actively Recruiting
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Led by Pfizer · Updated on 2026-05-11
124
Participants Needed
79
Research Sites
323 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.
CONDITIONS
Official Title
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of advanced or metastatic solid tumor excluding colorectal cancer
- Measurable disease by RECIST version 1.1
- Evidence of a BRAF V600 mutation
- Prior therapy per tumor cohort
- Adequate organ function per protocol
You will not qualify if you...
- Other active malignancy within 3 years
- Presence of leptomeningeal disease
- History or current evidence of retinal vein occlusion or retinal degenerative disease
- Concurrent neuromuscular disorder with elevated creatine kinase
- Active gastrointestinal disease as defined per protocol
- History of interstitial lung disease as defined per protocol
AI-Screening
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Trial Site Locations
Total: 79 locations
1
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35249
Actively Recruiting
3
University of Alabama at Birmingham - Phase I Clinical Trials Unit
Birmingham, Alabama, United States, 35249
Actively Recruiting
4
Highlands Oncology Group, PA
Fayetteville, Arkansas, United States, 72703
Actively Recruiting
5
Highlands Oncology Group, PA
Rogers, Arkansas, United States, 72758
Actively Recruiting
6
Highlands Oncology Group, PA
Springdale, Arkansas, United States, 72762
Actively Recruiting
7
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate
Los Angeles, California, United States, 90025
Actively Recruiting
8
Keck Hospital of USC
Los Angeles, California, United States, 90033
Not Yet Recruiting
9
Los Angeles General Medical Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
10
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
11
Keck Medical Center of USC Pasadena
Pasadena, California, United States, 91105
Not Yet Recruiting
12
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States, 94143
Actively Recruiting
13
UCSF Helen Diller Medical Center at Parnassus Heights
San Francisco, California, United States, 94143
Actively Recruiting
14
UCSF Medical Center, Investigational Pharmacy
San Francisco, California, United States, 94158
Actively Recruiting
15
The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only)
Santa Monica, California, United States, 90404
Actively Recruiting
16
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
Tampa, Florida, United States, 33612
Actively Recruiting
17
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
18
Moffitt McKinley Hospital
Tampa, Florida, United States, 33612
Actively Recruiting
19
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Not Yet Recruiting
20
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
21
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
22
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
23
Brigitte Harris Cancer Pavilion
Detroit, Michigan, United States, 48202
Actively Recruiting
24
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
25
HealthPartners Frauenshuh Cancer Center
Saint Louis Park, Minnesota, United States, 55426
Not Yet Recruiting
26
Methodist Hospital Inpatient Pharmacy
Saint Louis Park, Minnesota, United States, 55426
Not Yet Recruiting
27
HealthPartners Cancer Center at regions Hospital
Saint Paul, Minnesota, United States, 55101
Not Yet Recruiting
28
Regions Hospital Pharmacy
Saint Paul, Minnesota, United States, 55101
Not Yet Recruiting
29
MSK Basking Ridge.
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
30
MSK Monmouth.
Middletown, New Jersey, United States, 07748
Actively Recruiting
31
MSK Bergen.
Montvale, New Jersey, United States, 07645
Actively Recruiting
32
Optum Medical Care, PC
Brewster, New York, United States, 10509
Not Yet Recruiting
33
MSK Commack.
Commack, New York, United States, 11725
Actively Recruiting
34
MSK Westchester.
Harrison, New York, United States, 10604
Actively Recruiting
35
Optum Medical Care, PC
Mount Kisco, New York, United States, 10549
Not Yet Recruiting
36
Laura & Isaac Perlmutter Cancer Center - NYU ACC
New York, New York, United States, 10016
Actively Recruiting
37
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
38
NYU Langone Faculty Group Practice
New York, New York, United States, 10016
Actively Recruiting
39
NYU Langone Medical Center (Tisch Hospital)
New York, New York, United States, 10016
Actively Recruiting
40
Memorial Sloan Kettering Cancer Center 53rd street.
New York, New York, United States, 10022
Actively Recruiting
41
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
42
Columbia University Medical Center - Neurological Institute of New York
New York, New York, United States, 10032
Actively Recruiting
43
CUIMC Research Pharmacy
New York, New York, United States, 10032
Actively Recruiting
44
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States, 10065
Actively Recruiting
45
MSK Nassau.
Uniondale, New York, United States, 11553
Actively Recruiting
46
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
Cleveland, Ohio, United States, 44106
Actively Recruiting
47
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
48
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
49
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
50
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Not Yet Recruiting
51
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
52
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
53
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
54
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
55
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States, 53718
Actively Recruiting
56
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
57
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia, 3000
Actively Recruiting
58
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
59
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
60
ANIMI - Unidade de Tratamento Oncologico
Lages, Santa Catarina, Brazil, 88501001
Actively Recruiting
61
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
São Caetano do Sul, São Paulo, Brazil
Actively Recruiting
62
IBCC - Núcleo de Pesquisa e Ensino
São Paulo, Brazil, 04014-002
Actively Recruiting
63
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
64
Alberta Health Services and The Governors of The University of Alberta
Edmonton, Alberta, Canada, T6G 2C8
Actively Recruiting
65
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
66
Sunnybrook Research Institute
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
67
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
68
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
69
McGill University Health Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
70
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
71
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
72
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
73
Rabin Medical Center
Petah Tikva, Central District, Israel, 4941492
Actively Recruiting
74
Sheba Medical Center
Ramat Gan, Central District, Israel, 5265601
Actively Recruiting
75
Hadassah Medical Center
Jerusalem, Jerusalem, Israel, 9112001
Not Yet Recruiting
76
Soroka Medical Center
Beersheba, Southern District, Israel, 8410101
Actively Recruiting
77
Sourasky Medical Center
Tel Aviv, TELL ABĪB, Israel, 6423906
Actively Recruiting
78
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Not Yet Recruiting
79
Kansai Medical University Hospital
Hirakata, Osaka, Japan, 573-1191
Not Yet Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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