Actively Recruiting
A Phase 1a/b Open-Label Study of PF-07799544 Alone and with PF-07799933 in Adults with BRAF-Mutant Melanoma and Other Advanced Solid Tumors
Led by Pfizer · Updated on 2026-06-05
124
Participants Needed
83
Research Sites
98 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and effects of the study medicine PF-07799544, alone or combined with another medicine called PF-07799933, as a potential treatment for adults with advanced solid tumors that have a BRAF V600 mutation. This clinical trial includes two parts: Phase 1a testing PF-07799544 alone and Phase 1b testing PF-07799544 together with PF-07799933. Phase 1a is closed for enrollment, and Phase 1b focuses on participants with metastatic or recurrent solid tumors, excluding colorectal cancer, who have received prior cancer treatments. In this study, all participants receive both PF-07799544 and PF-07799933 as oral tablets taken twice daily at home. Treatment continues until the cancer stops responding, unacceptable side effects occur, or up to two years, with the option to continue beyond two years. The trial is designed to observe the experiences of participants using these medicines to assess safety and treatment effects. Participants will be monitored through regular assessments including evaluations of side effects, laboratory tests, vital signs, and physical exams from the start of treatment until 28 days after stopping the study drugs. The main measure is to track dose-limiting toxicities within the first 21 days of treatment cycles and overall response rate up to two years. Additional monitoring includes treatment-emergent adverse events, changes in lab results and vital signs, and pharmacokinetics to understand how the drugs behave in the body.
CONDITIONS
Brief Title
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of advanced or metastatic solid tumor excluding colorectal cancer
- Measurable disease by RECIST version 1.1
- Evidence of a BRAF V600 mutation in the tumor
- Prior therapy received as required per tumor cohort
- Adequate organ function according to study protocol
You will not qualify if you...
- Active malignancy other than the study tumor within the past 3 years
- Presence of leptomeningeal disease
- History or current evidence of retinal vein occlusion or retinal degenerative disease
- Neuromuscular disorder with elevated creatine kinase
- Active gastrointestinal disease as defined by study protocol
- History of interstitial lung disease as defined by study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Repeated 21-day cycles until disease progression or discontinuation
Participants receive study medicine PF-07799544 alone or in combination with PF-07799933 as part of dose escalation and expansion.
Visits every cycle for treatment and safety assessments
Duration - Up to 2 years
Participants are monitored for efficacy and safety outcomes after treatment ends, including response and adverse events up to 2 years.
Periodic visits during follow-up for assessments
Trial Site Locations
Total: 83 locations
1
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35249
Actively Recruiting
3
University of Alabama at Birmingham - Phase I Clinical Trials Unit
Birmingham, Alabama, United States, 35249
Actively Recruiting
4
Highlands Oncology Group, PA
Fayetteville, Arkansas, United States, 72703
Actively Recruiting
5
Highlands Oncology Group, PA
Rogers, Arkansas, United States, 72758
Actively Recruiting
6
Highlands Oncology Group, PA
Springdale, Arkansas, United States, 72762
Actively Recruiting
7
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate
Los Angeles, California, United States, 90025
Actively Recruiting
8
Keck Hospital of USC
Los Angeles, California, United States, 90033
Not Yet Recruiting
9
Los Angeles General Medical Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
10
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
11
Keck Medical Center of USC Pasadena
Pasadena, California, United States, 91105
Not Yet Recruiting
12
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States, 94143
Actively Recruiting
13
UCSF Helen Diller Medical Center at Parnassus Heights
San Francisco, California, United States, 94143
Actively Recruiting
14
UCSF Medical Center, Investigational Pharmacy
San Francisco, California, United States, 94158
Actively Recruiting
15
The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only)
Santa Monica, California, United States, 90404
Actively Recruiting
16
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
Tampa, Florida, United States, 33612
Actively Recruiting
17
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
18
Moffitt McKinley Hospital
Tampa, Florida, United States, 33612
Actively Recruiting
19
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Not Yet Recruiting
20
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
21
Ophthalmic Consultants of Boston Inc (OCB)
Boston, Massachusetts, United States, 02114
Actively Recruiting
22
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
23
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
24
Mass General Waltham
Waltham, Massachusetts, United States, 02451
Actively Recruiting
25
Brigitte Harris Cancer Pavilion
Detroit, Michigan, United States, 48202
Actively Recruiting
26
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
27
HealthPartners Frauenshuh Cancer Center
Saint Louis Park, Minnesota, United States, 55426
Not Yet Recruiting
28
Methodist Hospital Inpatient Pharmacy
Saint Louis Park, Minnesota, United States, 55426
Not Yet Recruiting
29
HealthPartners Cancer Center at regions Hospital
Saint Paul, Minnesota, United States, 55101
Not Yet Recruiting
30
Regions Hospital Pharmacy
Saint Paul, Minnesota, United States, 55101
Not Yet Recruiting
31
MSK Basking Ridge.
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
32
MSK Monmouth.
Middletown, New Jersey, United States, 07748
Actively Recruiting
33
MSK Bergen.
Montvale, New Jersey, United States, 07645
Actively Recruiting
34
Optum Medical Care, PC
Brewster, New York, United States, 10509
Not Yet Recruiting
35
MSK Commack.
Commack, New York, United States, 11725
Actively Recruiting
36
MSK Westchester.
Harrison, New York, United States, 10604
Actively Recruiting
37
Optum Medical Care, PC
Mount Kisco, New York, United States, 10549
Not Yet Recruiting
38
Laura & Isaac Perlmutter Cancer Center - NYU ACC
New York, New York, United States, 10016
Actively Recruiting
39
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
40
NYU Langone Faculty Group Practice
New York, New York, United States, 10016
Actively Recruiting
41
NYU Langone Medical Center (Tisch Hospital)
New York, New York, United States, 10016
Actively Recruiting
42
Memorial Sloan Kettering Cancer Center 53rd street.
New York, New York, United States, 10022
Actively Recruiting
43
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
44
Columbia University Medical Center - Neurological Institute of New York
New York, New York, United States, 10032
Actively Recruiting
45
CUIMC Research Pharmacy
New York, New York, United States, 10032
Actively Recruiting
46
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States, 10065
Actively Recruiting
47
MSK Nassau.
Uniondale, New York, United States, 11553
Actively Recruiting
48
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
Cleveland, Ohio, United States, 44106
Actively Recruiting
49
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
50
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
51
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
52
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Not Yet Recruiting
53
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
54
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
55
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
56
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
57
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States, 53718
Actively Recruiting
58
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
59
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia, 3000
Actively Recruiting
60
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
61
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
62
ANIMI - Unidade de Tratamento Oncologico
Lages, Santa Catarina, Brazil, 88501001
Actively Recruiting
63
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
São Caetano do Sul, São Paulo, Brazil, 09541-270
Actively Recruiting
64
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
São Caetano do Sul, São Paulo, Brazil
Actively Recruiting
65
IBCC - Núcleo de Pesquisa e Ensino
São Paulo, Brazil, 04014-002
Actively Recruiting
66
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
67
Alberta Health Services and The Governors of The University of Alberta
Edmonton, Alberta, Canada, T6G 2C8
Actively Recruiting
68
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
69
Sunnybrook Research Institute
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
70
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
71
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
72
McGill University Health Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
73
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
74
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Not Yet Recruiting
75
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
76
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
77
Rabin Medical Center
Petah Tikva, Central District, Israel, 4941492
Actively Recruiting
78
Sheba Medical Center
Ramat Gan, Central District, Israel, 5265601
Actively Recruiting
79
Hadassah Medical Center
Jerusalem, Jerusalem, Israel, 9112001
Not Yet Recruiting
80
Soroka Medical Center
Beersheba, Southern District, Israel, 8410101
Actively Recruiting
81
Sourasky Medical Center
Tel Aviv, TELL ABĪB, Israel, 6423906
Actively Recruiting
82
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Actively Recruiting
83
Kansai Medical University Hospital
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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