Actively Recruiting
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Led by Pfizer · Updated on 2026-03-27
1156
Participants Needed
32
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.
CONDITIONS
Official Title
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of COPD for at least 12 months according to GOLD definition
- Post-bronchodilator FEV1/FVC ratio less than 70% and FEV1 between 30% and less than 70% predicted
- Continuous treatment with LABA + LAMA + ICS triple therapy for at least 6 months before screening, stable dose for at least 3 months
- History of at least 2 moderate or severe COPD exacerbations within the last 12 months
- Age between 35 and 80 years
You will not qualify if you...
- Significant lung disease other than COPD
- Need for continuous oxygen treatment at more than 4.0 liters per minute
- Resting blood oxygen saturation less than 88% on room air or usual oxygen
- Clinically significant cardiovascular disease, severe or acute heart failure, or cor pulmonale
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
SEC Clinical Research
Dothan, Alabama, United States, 36305
Not Yet Recruiting
2
Pulmonary Associates of Mobile, P.C.
Mobile, Alabama, United States, 36608
Not Yet Recruiting
3
Chandler Clinical Trials
Chandler, Arizona, United States, 85224
Not Yet Recruiting
4
Pulmonary Associates, PA
Phoenix, Arizona, United States, 85027
Actively Recruiting
5
IMAX Clinical Trials
La Palma, California, United States, 90623
Not Yet Recruiting
6
NewportNativeMD, Inc.
Newport Beach, California, United States, 92663
Actively Recruiting
7
California Medical Research Associates
Northridge, California, United States, 91324
Not Yet Recruiting
8
Institute of HealthCare Assessment d/b/a Apex Clinical Research
San Diego, California, United States, 92120
Actively Recruiting
9
Advanced Pulmonary Research Institute
Loxahatchee Groves, Florida, United States, 33470
Actively Recruiting
10
Reed Medical Research
Miami, Florida, United States, 33176
Actively Recruiting
11
Coastal Medical Research Institute, LLC
St. Petersburg, Florida, United States, 33704
Not Yet Recruiting
12
Coastal Pulmonary and Critical Care, P.L.C
St. Petersburg, Florida, United States, 33704
Not Yet Recruiting
13
Cpcc-Research Llc
East Point, Georgia, United States, 30344
Actively Recruiting
14
Centricity Research Rincon Pulmonology
Rincon, Georgia, United States, 31326
Actively Recruiting
15
ASHA Clinical Research - Munster, LLC
Hammond, Indiana, United States, 46324
Not Yet Recruiting
16
Methodist Hospital Southlake
Merrillville, Indiana, United States, 46410
Not Yet Recruiting
17
Paul A. Shapero, MD, PA
Bangor, Maine, United States, 04401
Not Yet Recruiting
18
Revival Research Institute, LLC
Dearborn, Michigan, United States, 48126
Actively Recruiting
19
Revive Research Institute, Inc.
Southfield, Michigan, United States, 48075
Actively Recruiting
20
Henderson Clinical Trials
Henderson, Nevada, United States, 89052
Not Yet Recruiting
21
Salem Chest Specialists
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
22
Southeastern Research Center
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
23
Toledo Institute of Clinical Research Inc.
Toledo, Ohio, United States, 43617
Not Yet Recruiting
24
Clinical Research Associates of Central PA, LLC
DuBois, Pennsylvania, United States, 15801
Actively Recruiting
25
Velocity Clinical Research, Gaffney
Gaffney, South Carolina, United States, 29340
Actively Recruiting
26
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States, 29732
Actively Recruiting
27
Velocity Clinical Research, Spartanburg
Spartanburg, South Carolina, United States, 29303
Actively Recruiting
28
Health Concepts
Rapid City, South Dakota, United States, 57702
Not Yet Recruiting
29
Premier Research Center, LLC
Hendersonville, Tennessee, United States, 37075
Actively Recruiting
30
Sherman Clinical Research
Sherman, Texas, United States, 75090
Not Yet Recruiting
31
Dr. Syed Anees Medicine Professional Corporation
Windsor, Ontario, Canada, N8X 1T3
Actively Recruiting
32
Nishifukuoka Hospital
Fukuoka, Fukuoka, Japan, 819-8555
Not Yet Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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