Actively Recruiting
A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
Led by Pfizer · Updated on 2026-04-13
840
Participants Needed
58
Research Sites
325 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to people with gastroesophageal cancer that is locally advanced (spread to nearby tissues) or has spread to other parts of the body. To join the study, participants must meet the following conditions: Be 18 years or older. Have locally advanced or metastatic gastric, gastroesophageal junction or esophageal adenocarcinoma Be treatment naïve for advanced or metastatic disease Be in good physical condition and have healthy organs based on medical tests. The study has two parts: * In the first part, researchers will check how safe the study medicine in combination with chemotherapy is and how well people respond to it. * In the second part, they will compare study medicine plus chemotherapy to another approved treatment (nivolumab plus chemotherapy) to see which works better. The treatment will be given in repeated time periods called cycles.
CONDITIONS
Official Title
A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological or cytological confirmation of gastric, gastroesophageal junction, or esophageal adenocarcinoma
- Locally advanced or metastatic disease
- Eastern Cooperative Oncology Group performance status of 0 or 1
- No prior systemic therapy for advanced or metastatic disease
- Adequate liver, hepatic, and kidney function
- HER-2 negative status based on local testing
- PD-L1 positive status based on local testing
- Age 18 years or older
You will not qualify if you...
- Known active central nervous system metastases or spinal cord metastases or compression
- Clinically significant risk of bleeding or fistula
- Major surgery or severe trauma within 4 weeks before first dose or planned major surgery during study
- History of allogeneic organ or hematopoietic stem cell transplantation
- Grade 3 or higher bleeding within 28 days before treatment or history of significant bleeding
- Clinically significant cardiovascular disease or other major health problems within 6 months before first dose
- Active autoimmune disease requiring systemic treatment within past 2 years
- Evidence of non-infectious or drug-induced interstitial lung disease or pneumonitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 58 locations
1
Rocky Mountain Cancer Centers, LLP
Aurora, Colorado, United States, 80012
Actively Recruiting
2
Rocky Mountain Cancer Centers, LLP
Boulder, Colorado, United States, 80303
Actively Recruiting
3
Rocky Mountain Cancer Centers, LLP
Centennial, Colorado, United States, 80112
Actively Recruiting
4
Rocky Mountain Cancer Centers, LLP
Colorado Springs, Colorado, United States, 80907
Actively Recruiting
5
Rocky Mountain Cancer Centers, LLP
Colorado Springs, Colorado, United States, 80923
Actively Recruiting
6
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States, 80218
Actively Recruiting
7
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States, 80220
Actively Recruiting
8
Rocky Mountain Cancer Centers, LLP
Englewood, Colorado, United States, 80113
Actively Recruiting
9
Rocky Mountain Cancer Centers, LLP
Lakewood, Colorado, United States, 80228
Actively Recruiting
10
Rocky Mountain Cancer Centers, LLP
Littleton, Colorado, United States, 80120
Actively Recruiting
11
Rocky Mountain Cancer Centers, LLP
Lone Tree, Colorado, United States, 80124
Actively Recruiting
12
Rocky Mountain Cancer Centers, LLP
Longmont, Colorado, United States, 80504
Actively Recruiting
13
Rocky Mountain Cancer Centers, LLP
Pueblo, Colorado, United States, 81003
Actively Recruiting
14
Rocky Mountain Cancer Centers, LLP
Thornton, Colorado, United States, 80260
Actively Recruiting
15
Illinois Cancer Specialists
Arlington Heights, Illinois, United States, 60005
Actively Recruiting
16
Illinois CancerCare - Bloomington
Bloomington, Illinois, United States, 61704
Actively Recruiting
17
Illinois Cancer Specialists
Chicago, Illinois, United States, 60631
Actively Recruiting
18
Illinois CancerCare - Galesburg
Galesburg, Illinois, United States, 61401
Actively Recruiting
19
Illinois Cancer Specialists
Niles, Illinois, United States, 60714
Actively Recruiting
20
Illinois CancerCare-Ottawa-Fox River Cancer Center
Ottawa, Illinois, United States, 61350
Actively Recruiting
21
Illinois CancerCare-Pekin
Pekin, Illinois, United States, 61554
Actively Recruiting
22
Illinois CancerCare, P.C.
Peoria, Illinois, United States, 61615
Actively Recruiting
23
Illinois CancerCare-Peru - Valley Regional Cancer Center
Peru, Illinois, United States, 61354
Actively Recruiting
24
Illinois CancerCare-Washington
Washington, Illinois, United States, 61571
Actively Recruiting
25
Maryland Oncology Hematology, P.A.
Annapolis, Maryland, United States, 21401
Actively Recruiting
26
Maryland Oncology Hematology, P.A.
Bethesda, Maryland, United States, 20817
Actively Recruiting
27
Maryland Oncology Hematology, P.A.
Brandywine, Maryland, United States, 20613
Actively Recruiting
28
Maryland Oncology Hematology, P.A.
Columbia, Maryland, United States, 21044
Actively Recruiting
29
Maryland Oncology Hematology, P.A.
Germantown, Maryland, United States, 20876
Actively Recruiting
30
Maryland Oncology Hematology, P.A.
Largo, Maryland, United States, 20774
Actively Recruiting
31
Maryland Oncology Hematology, P.A.
Rockville, Maryland, United States, 20850
Actively Recruiting
32
Maryland Oncology Hematology, P.A.
Silver Spring, Maryland, United States, 20904
Actively Recruiting
33
Renown Health Medical Oncology
Reno, Nevada, United States, 89502
Actively Recruiting
34
Renown Office of Clinical Research
Reno, Nevada, United States, 89502
Actively Recruiting
35
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
36
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States, 45211
Actively Recruiting
37
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States, 45242
Actively Recruiting
38
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States, 45245
Actively Recruiting
39
Oncology Hematology Care Clinical Trials, LLC
Fairfield, Ohio, United States, 45014
Actively Recruiting
40
Alliance Cancer Specialists, PC
Bensalem, Pennsylvania, United States, 19020
Actively Recruiting
41
Alliance Cancer Specialists, PC
Doylestown, Pennsylvania, United States, 18901
Actively Recruiting
42
Alliance Cancer Specialists, PC
Langhorne, Pennsylvania, United States, 19047
Actively Recruiting
43
Alliance Cancer Specialists, PC
Media, Pennsylvania, United States, 19063
Actively Recruiting
44
Alliance Cancer Specialists, PC
Sellersville, Pennsylvania, United States, 18960
Actively Recruiting
45
Alliance Cancer Specialists, PC
Wynnewood, Pennsylvania, United States, 19096
Actively Recruiting
46
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States, 75063
Actively Recruiting
47
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States, 75063
Not Yet Recruiting
48
Virginia Cancer Specialists, PC
Arlington, Virginia, United States, 22201
Not Yet Recruiting
49
Virginia Oncology Associates
Chesapeake, Virginia, United States, 23320
Not Yet Recruiting
50
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States, 22031
Not Yet Recruiting
51
Virginia Oncology Associates
Hampton, Virginia, United States, 23666
Not Yet Recruiting
52
Virginia Cancer Specialists, PC
Manassas, Virginia, United States, 20110
Not Yet Recruiting
53
Virginia Oncology Associates
Newport News, Virginia, United States, 23606
Not Yet Recruiting
54
Virginia Oncology Associates
Norfolk, Virginia, United States, 23502
Not Yet Recruiting
55
Virginia Cancer Specialists, PC
Reston, Virginia, United States, 20190
Not Yet Recruiting
56
Virginia Oncology Associates
Virginia Beach, Virginia, United States, 23456
Not Yet Recruiting
57
Virginia Cancer Specialists, PC
Woodbridge, Virginia, United States, 22191
Not Yet Recruiting
58
Pan American Center for Oncology Trials, LLC - Manati Office
Manati, United States, Puerto Rico, 00674
Not Yet Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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