Actively Recruiting
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
Led by Pfizer · Updated on 2026-05-05
944
Participants Needed
90
Research Sites
295 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to (1) learn whether the BCMA-CD3 bispecific antibody elranatamab can provide more benefit to people with multiple myeloma compared to a combination therapy including daratumumab, pomalidomide, and dexamethasone, and (2) learn about the safety and activity of elranatamab in combination with the anti-CD38 monoclonal antibody daratumumab. People with multiple myeloma who have received previous treatment including lenalidomide will be enrolled in the study. Part 1 of the study will assess the safety and activity of different doses of elranatamab in combination with daratumumab. People participating in Part 2 of the study will be randomly assigned to receive either elranatamab alone, elranatamab plus daratumumab, or daratumumab, pomalidomide, and dexamethasone. Part 2 will evaluate the safety and activity of (1) elranatamab alone compared to daratumumab, pomalidomide, and dexamethasone, and (2) elranatamab plus daratumumab. Part 3 will assess the effect of increased measures to protect against infection in people treated with either elranatamab alone or together with daratumumab. All people participating in the study will receive study treatment until their disease progresses, they experience unacceptable side effects, or they choose to no longer participate in the study.
CONDITIONS
Official Title
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prior diagnosis of multiple myeloma based on IMWG criteria
- Measurable disease with serum M-protein 650.5 g/dL, or urinary M-protein 65200 mg/24 hours, or serum immunoglobulin FLC 6510 mg/dL with abnormal kappa to lambda ratio
- Previous treatment including lenalidomide for multiple myeloma
- ECOG performance status of 2 or less
- Acute effects of prior therapy resolved to baseline or CTCAE Grade 1 or less
- Not pregnant and willing to use contraception
You will not qualify if you...
- Smoldering multiple myeloma
- Plasma cell leukemia
- Amyloidosis
- POEMS Syndrome
- Stem cell transplant within 12 weeks before enrollment or active graft versus host disease
- Active infections including HBV, HCV, SARS-CoV2, HIV, or uncontrolled bacterial, fungal, or viral infections
- Any other active cancer within 3 years except treated basal cell or squamous cell skin cancer or carcinoma in situ
- Prior treatment with BCMA-directed therapy
- Live attenuated vaccine within 4 weeks before first study dose
- Use of investigational products within 30 days before first study dose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 90 locations
1
Clovis Community Medical Center
Clovis, California, United States, 93611
Active, Not Recruiting
2
Community Regional Medical Center
Fresno, California, United States, 93721
Active, Not Recruiting
3
UCHealth Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Active, Not Recruiting
4
UCHealth Greeley Hospital
Greeley, Colorado, United States, 80634
Active, Not Recruiting
5
Sylvester Comprehensive Cancer Center - Aventura
Aventura, Florida, United States, 33180
Actively Recruiting
6
Sylvester Comprehensive Cancer Center - Coral Springs
Coral Springs, Florida, United States, 33065
Actively Recruiting
7
University of Miami Hospital and Clinics - Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Actively Recruiting
8
Sylvester Comprehensive Cancer Center - Hollywood
Hollywood, Florida, United States, 33021
Actively Recruiting
9
University of Miami Hospital and Clinics
Miami, Florida, United States, 33136
Actively Recruiting
10
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, New York, United States, 10021
Actively Recruiting
11
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States, 10065
Actively Recruiting
12
Hospital Universitario Austral
Presidente Derqui, Buenos Aires, Argentina, B1629AHJ
Active, Not Recruiting
13
Pindara Private Hospital
Benowa, Queensland, Australia, 4217
Actively Recruiting
14
QScan Radiology Clinics
Clayfield, Queensland, Australia, 4011
Actively Recruiting
15
Gallipoli Medical Research Foundation
Greenslopes, Queensland, Australia, 4120
Active, Not Recruiting
16
Slade Pharmacy
Richmond, Victoria, Australia, 3121
Actively Recruiting
17
Linear Clinical Research
Perth, Western Australia, Australia, 6009
Active, Not Recruiting
18
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, Estado de Bahia, Brazil, 41253-190
Active, Not Recruiting
19
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Porto Alegre, Rio Grande do Sul, Brazil, 90110-270
Active, Not Recruiting
20
Hospital Mae de Deus
Porto Alegre, Rio Grande do Sul, Brazil, 90880-480
Active, Not Recruiting
21
Clínica Médica São Germano LTDA
SP, São Paulo, Brazil, 04537-080
Active, Not Recruiting
22
Instituto de Educação, Pesquisa e Gestão em Saúde
Rio de Janeiro, Brazil, 22793-080
Active, Not Recruiting
23
HU UNIFESP / SPDM - Hospital São Paulo
São Paulo, Brazil, 04024-002
Active, Not Recruiting
24
Clínica Médica São Germano S/S Ltda
São Paulo, Brazil, 04537-080
Active, Not Recruiting
25
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, Brazil, 04543-000
Active, Not Recruiting
26
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, Brazil, 04544-000
Active, Not Recruiting
27
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec, Canada, H1T2M4
Active, Not Recruiting
28
Saskatoon Cancer Center
Saskatoon, Saskatchewan, Canada, S7N4H4
Actively Recruiting
29
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
30
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
31
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510555
Actively Recruiting
32
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030
Actively Recruiting
33
Nanjing Drum Tower Hospital ， The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China, 210008
Actively Recruiting
34
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China, 221006
Active, Not Recruiting
35
Shandong Provincial Hospital
Jinan, Shandong, China, 250021
Active, Not Recruiting
36
Institute of hematology&blood disease hospital
Tianjin, Tianjin Municipality, China, 301636
Actively Recruiting
37
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing, China, 100730
Active, Not Recruiting
38
Chongqing University Cancer Hospital
Chongqing, China, 400030
Actively Recruiting
39
Fakultní nemocnice Brno Bohunice
Brno, Brno-m?sto, Czechia, 625 00
Active, Not Recruiting
40
Fakultni Nemocnice Plzen
Plzen - Lochotin, Plzeň Region, Czechia, 304 60
Actively Recruiting
41
Fakultni poliklinika
Prague, Praha 2, Czechia, 120 00
Actively Recruiting
42
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
Helsinki, Finland, 00029
Active, Not Recruiting
43
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges, Limousin, France, 87042
Actively Recruiting
44
Hôpital Saint Antoine
Paris, France, 75571
Actively Recruiting
45
Centre Hospitalier Lyon Sud - Service d'Hematologie Clinique
Pierre-Bénite, France, 69495
Active, Not Recruiting
46
Charité Universitätsmedizin Berlin
Berlin, Germany, 12203
Active, Not Recruiting
47
Universitätsklinikum rechts der Isar, Technische Universität München (TUM)
München, Germany, 81675
Actively Recruiting
48
Alexandra General Hospital of Athens
Athens, Attikí, Greece, 115 28
Active, Not Recruiting
49
Theageneio Cancer Hospital of Thessaloniki
Thessaloniki, Kentrikí Makedonía, Greece, 546 39
Active, Not Recruiting
50
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Lombardy, Italy, 20122
Actively Recruiting
51
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy, 40138
Active, Not Recruiting
52
National Hospital Organization Shibukawa Medical Center
Shibukawa, Gunma, Japan, 377-0280
Active, Not Recruiting
53
Tohoku University Hospital
Sendai, Miyagi, Japan, 980-8574
Active, Not Recruiting
54
Akita University Hospital
Akita, Japan, 010-8543
Actively Recruiting
55
National Hospital Organization Kumamoto Medical Center
Kumamoto, Japan, 860-0008
Actively Recruiting
56
Nagasaki University Hospital
Nagasaki, Japan, 852-8501
Actively Recruiting
57
National Hospital Organization Okayama Medical Center
Okayama, Japan, 701-1192
Active, Not Recruiting
58
Yamagata University Hospital
Yamagata, Japan, 990-9585
Active, Not Recruiting
59
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, Mexico, 66460
Active, Not Recruiting
60
North Shore Hospital
Auckland, New Zealand, 0622
Active, Not Recruiting
61
Labtests Auckland Ltd.
Auckland, New Zealand, 1060
Active, Not Recruiting
62
Aotearoa Clinical Trials
Auckland, New Zealand, 2025
Active, Not Recruiting
63
Waikato District Health Board, Waikato Hospital
Hamilton, New Zealand, 3204
Active, Not Recruiting
64
Palmerston North Hospital
Roslyn, New Zealand, 4414
Active, Not Recruiting
65
Oslo Universitetssykehus Ullevål
Oslo, Norway, 0450
Active, Not Recruiting
66
St Olavs Hospital
Trondheim, Norway, 7030
Active, Not Recruiting
67
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy Klinika Hematologii
Bydgoszcz, Poland, 85-168
Active, Not Recruiting
68
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, Poland, 60-569
Active, Not Recruiting
69
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
Wroclaw, Poland, 50-367
Active, Not Recruiting
70
Institut Català d'Oncologia - L'Hospitalet
L'Hospitalet Del Llobregat, Barcelona [barcelona], Spain, 08908
Actively Recruiting
71
Hospital Universitari Mutua Terrassa
Terrassa, Barcelona, Spain, 08221
Active, Not Recruiting
72
Clinica Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
73
Hospital Universitario de Toledo
Toledo, Other, Spain, 45007
Active, Not Recruiting
74
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
75
Hospital Universitari De Girona Doctor Josep Trueta
Girona, Spain, 17007
Active, Not Recruiting
76
Hospital Universitario La Princesa
Madrid, Spain, 28006
Actively Recruiting
77
Hospital Universitario Madrid Sanchinarro
Madrid, Spain, 28050
Active, Not Recruiting
78
Hospital Universitario de Salamanca
Salamanca, Spain, 37007
Active, Not Recruiting
79
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Active, Not Recruiting
80
Skånes Universitetssjukhus Lund
Lund, Skåne LÄN [se-12], Sweden, 22185
Active, Not Recruiting
81
Falu Lasarett
Falun, Sweden, 791 82
Active, Not Recruiting
82
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden, 41345
Active, Not Recruiting
83
Universitetssjukhuset Örebro
Örebro, Örebro LÄN [se-18], Sweden, 701 85
Active, Not Recruiting
84
China Medical University Hospital
Taichung, Taiwan, 40447
Active, Not Recruiting
85
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Active, Not Recruiting
86
National Taiwan University Hospital
Taipei, Taiwan, 10002
Active, Not Recruiting
87
Ege Universitesi Hastanesi
Izmir, İ̇zmir, Turkey (Türkiye), 35100
Active, Not Recruiting
88
Dokuz Eylul Universitesi Hastanesi
Izmir, İ̇zmir, Turkey (Türkiye), 35340
Active, Not Recruiting
89
Akdeniz Universitesi Hastanesi
Antalya, Turkey (Türkiye), 07070
Active, Not Recruiting
90
University Hospital of Wales
Cardiff, South Glamorgan, United Kingdom, CF14 4XW
Active, Not Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
6
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