Actively Recruiting
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
Led by Pfizer · Updated on 2026-05-04
340
Participants Needed
98
Research Sites
184 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn about the safety and effects of 2 study medicines (PF-07275315 and PF-07264660) for the treatment of atopic dermatitis (AD). AD is a long- lasting itchy red rash, caused by a skin reaction. This study is seeking participants who: * are 18 years of age or more. * Were confirmed to have AD at least 6 months ago. * Are not having an effective treatment result from medicines that are applied on skin for AD. * Are considered by their doctors to have moderate to severe AD. In Stage 1 of the study, participants will receive either PF-07275315 or PF-07264660 or placebo. Stage 1 is complete. In Stage 2 of the study participants will receive either PF-07275315 or placebo. In Stage 3 of the study participants who have received anti-inflammatory proteins, will receive either PF-07275315 or placebo. In Stage 4 of the study participants will receive either PF-07264660 or placebo. A placebo does not have any medicine in it but looks just like the medicines being studied. PF-07275315 or PF-07264660 or placebo will be given as multiple shots in the clinic over the course of each Stage. The experiences of people receiving PF-07275315 or PF-07264660 will be compared to people who do not. This will help determine if PF-07275315 and PF-07264660 are safe and effective. Participants in Stages 1, 2 and 4 will be involved in this study for up to 40 weeks (10 months). Participants in Stage 3 will be involved in this study for up to 52 weeks (13 months).
CONDITIONS
Official Title
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older
- Clinical diagnosis of chronic atopic dermatitis for at least 6 months confirmed by photograph
- Inadequate response to standard topical treatments for atopic dermatitis for at least 4 consecutive weeks within the past 6 to 12 months or medical reason why topical treatments are inappropriate
- Moderate to severe atopic dermatitis defined by affected body surface area 10% or more, vIGA score 3 or higher, and EASI score 16 or higher at screening and baseline visits
- Bio-experienced cohort: partial or non-responder to anti-inflammatory proteins, intolerance, adverse events, or loss of access to such treatments within 5 years
- Body mass index (BMI) between 17.5 and 40 kg/m2 and weight greater than 45 kg (100 lbs)
- Willing and able to comply with all scheduled visits, treatment plans, laboratory tests, and study procedures
You will not qualify if you...
- Significant allergic or autoimmune diseases other than atopic dermatitis, including but not limited to SLE, Type 1 diabetes, IBD, or Multiple Sclerosis
- History of significant allergic reactions including anaphylaxis or hypersensitivity to study drugs or their components
- Active infection requiring treatment within 2 weeks prior to screening or serious infection requiring hospitalization or systemic therapy within 60 days prior to Day 1
- Active chronic or acute skin infections requiring systemic antibiotics or other treatments within 2 weeks prior to Day 1, or superficial skin infections within 1 week prior to Day 1
- Any opportunistic or clinically significant infection within 6 months prior to Day 1
- History or current evidence of other inflammatory skin conditions that could affect evaluation
- Medical or psychiatric conditions, including recent or active suicidal ideation or behavior, that increase study risk or make participation inappropriate
- Use of prohibited medications
- Phototherapy or tanning booth use within 4 weeks prior to Day 1
- Previous use of investigational products within 30 days or 5 half-lives before first study dose
- HIV infection or infection with hepatitis B or C viruses
- Active or latent tuberculosis infection or inadequate treatment for tuberculosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 98 locations
1
Allervie Clinical Research
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
Onyx Clinical Research - Peoria
Peoria, Arizona, United States, 85381
Actively Recruiting
3
Medical Dermatology Specialists
Phoenix, Arizona, United States, 85006
Actively Recruiting
4
Onyx Clinical Research
Phoenix, Arizona, United States, 85050
Actively Recruiting
5
Banner - University Medicine Dermatology Clinic
Tucson, Arizona, United States, 85718
Actively Recruiting
6
Marvel Clinical Research
Huntington Beach, California, United States, 92647
Actively Recruiting
7
California Allergy and Asthma Medical Group
Los Angeles, California, United States, 90025
Actively Recruiting
8
University Dermatology Trials, INC.
Newport Beach, California, United States, 92660
Actively Recruiting
9
Northridge Clinical Trials
Northridge, California, United States, 91325
Actively Recruiting
10
Profound Research LLC
Oceanside, California, United States, 92056
Actively Recruiting
11
Dermatology Cosmetic Laser Medical Associates of La Jolla, Inc.
San Diego, California, United States, 92121
Actively Recruiting
12
West Dermatology La Jolla
San Diego, California, United States, 92121
Actively Recruiting
13
Sunwise Clinical Research
Walnut Creek, California, United States, 94596
Terminated
14
AboutSkin Research, LLC
Greenwood Village, Colorado, United States, 80111
Terminated
15
Renaissance Research and Medical Group
Cape Coral, Florida, United States, 33991
Active, Not Recruiting
16
Florida International Medical Research
Coral Gables, Florida, United States, 33134
Terminated
17
Revival Research
Doral, Florida, United States, 33122
Actively Recruiting
18
St. Jude Clinical Research
Doral, Florida, United States, 33172
Terminated
19
SouthCoast Research Center
Miami, Florida, United States, 33136
Terminated
20
Floridian Research Institute Llc
Miami, Florida, United States, 33179
Actively Recruiting
21
Global Health Research Center, Inc.
Miami Lakes, Florida, United States, 33016
Actively Recruiting
22
Ziaderm Research LLC
North Miami Beach, Florida, United States, 33162
Actively Recruiting
23
Clinical Neuroscience Solutions, Inc.
Orlando, Florida, United States, 32801
Actively Recruiting
24
GCP Research, Global Clinical professionals
St. Petersburg, Florida, United States, 33705
Actively Recruiting
25
ForCare Clinical Research
Tampa, Florida, United States, 33613
Actively Recruiting
26
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States, 46250
Actively Recruiting
27
Southern Indiana Clinical Trials
New Albany, Indiana, United States, 47150
Actively Recruiting
28
Maryland Laser Skin and Vein
Hunt Valley, Maryland, United States, 21030
Actively Recruiting
29
Michigan Center for Research Company
Clarkston, Michigan, United States, 48346
Actively Recruiting
30
MI Skin Innovations
Northville, Michigan, United States, 48167
Actively Recruiting
31
Revival Research Institute LLC
Troy, Michigan, United States, 48084
Actively Recruiting
32
Skin Specialists, PC dba Schlessinger MD
Omaha, Nebraska, United States, 68144
Actively Recruiting
33
Empire Dermatology
East Syracuse, New York, United States, 13057
Actively Recruiting
34
Private Practice - Dr. Bobby Buka
New York, New York, United States, 10012
Actively Recruiting
35
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
36
Sadick Research Group
New York, New York, United States, 10075
Actively Recruiting
37
Apex Clinical Research Center
Mayfield Heights, Ohio, United States, 44124
Actively Recruiting
38
Epic Medical Research - Oklahoma
Chickasha, Oklahoma, United States, 73018
Actively Recruiting
39
Unity Clinical Research
Oklahoma City, Oklahoma, United States, 73118
Actively Recruiting
40
Vital Prospects Clinical Research Institute, PC
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
41
Velocity Clinical Research, Medford
Medford, Oregon, United States, 97504
Active, Not Recruiting
42
Paddington Testing Co, Inc
Philadelphia, Pennsylvania, United States, 19103
Actively Recruiting
43
Clinical Partners, LLC
Johnston, Rhode Island, United States, 02919
Actively Recruiting
44
National Allergy and Asthma
North Charleston, South Carolina, United States, 29420
Actively Recruiting
45
Spartanburg Medical Research
Spartanburg, South Carolina, United States, 29303
Actively Recruiting
46
Clinical Neuroscience Solutions Inc.
Memphis, Tennessee, United States, 38119
Actively Recruiting
47
Dermatology Treatment and Research Center
Dallas, Texas, United States, 75230
Actively Recruiting
48
North Texas Center for Clinical Research
Frisco, Texas, United States, 75034
Actively Recruiting
49
Alpesh D. Desai, DO PLLC
Houston, Texas, United States, 77008
Active, Not Recruiting
50
DCT-Stone Oak, LLC dba Discovery Clinical Trials
San Antonio, Texas, United States, 78258
Actively Recruiting
51
Complete Dermatology
Sugar Land, Texas, United States, 77479
Actively Recruiting
52
Virginia Dermatology and Skin Cancer Center
Norfolk, Virginia, United States, 23502
Terminated
53
Australian Clinical Research Network
Sydney, New South Wales, Australia, NSW 2035
Actively Recruiting
54
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Actively Recruiting
55
Sinclair Dermatology
East Melbourne, Victoria, Australia, 3002
Actively Recruiting
56
Fremantle Dermatology
Fremantle, Western Australia, Australia, 6160
Actively Recruiting
57
Wiseman Dermatology Research Inc.
Winnipeg, Manitoba, Canada, R3M 3Z4
Actively Recruiting
58
Medicor Research Inc
Greater Sudbury, Ontario, Canada, P3C 1X3
Actively Recruiting
59
Sudbury Skin Clinique
Greater Sudbury, Ontario, Canada, P3C 1X8
Actively Recruiting
60
Lima's Excellence in Allergy and Dermatology Research
Hamilton, Ontario, Canada, L8L 3C3
Actively Recruiting
61
DermEdge Research
Mississauga, Ontario, Canada, L4Y 4C5
Actively Recruiting
62
Toronto Research Centre
Toronto, Ontario, Canada, M3H 5Y8
Actively Recruiting
63
INTERMED Groupe Sante
Chicoutimi, Quebec, Canada, G7H 7Y8
Actively Recruiting
64
Centre de Recherche Saint-Louis inc.
Québec, Canada, G1W 4R4
Actively Recruiting
65
Beijing Friendship Hospital Affiliate of Capital University
Beijing, Beijing Municipality, China, 100050
Actively Recruiting
66
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, Fujian, China, 350005
Actively Recruiting
67
Dongguan People's Hospital
Dongguan, Guangdong, China, 523109
Not Yet Recruiting
68
Guangdong Province Dermatology Hospital
Guangzhou, Guangdong, China, 510091
Actively Recruiting
69
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050031
Actively Recruiting
70
The Second Xiangya Hospital of Central South University
Changsha, Hu'nan, China, 410011
Actively Recruiting
71
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China, 430000
Actively Recruiting
72
Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, China, 212001
Not Yet Recruiting
73
Dermatology Hospital of Jiangxi Province
Nanchang, Jiangxi, China, 330000
Actively Recruiting
74
The first hospital of jilin university
Changchun, Jilin, China, 130021
Actively Recruiting
75
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Actively Recruiting
76
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
77
Chengdu second people's hospital
Chengdu, Sichuan, China, 610017
Actively Recruiting
78
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China, 300052
Not Yet Recruiting
79
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650032
Actively Recruiting
80
Hangzhou Third Hospital
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
81
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310014
Not Yet Recruiting
82
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310016
Actively Recruiting
83
Shanghai First People's Hospital
Shanghai, China, 201620
Actively Recruiting
84
Fachklinik Bad Bentheim
Bad Bentheim, Lower Saxony, Germany, 48455
Actively Recruiting
85
BAG Drs. Med. Quist PartG
Mainz, Rhineland-Palatinate, Germany, 55128
Actively Recruiting
86
Magdeburger Company for Medical Studies and Services
Magdeburg, Saxony-Anhalt, Germany, 39104
Actively Recruiting
87
Nomura Dermatology Clinic
Yokohama, Kanagawa, Japan, 221-0825
Actively Recruiting
88
Medical Corporation Heishinkai OPHAC Hospital
Osaka, Osaka, Japan, 532-0003
Active, Not Recruiting
89
Osaka Metropolitan University Hospital
Osaka, Osaka, Japan, 545-8586
Actively Recruiting
90
Nihonbashi Sakura Clinic
Chuo-ku, Tokyo, Japan, 103-0025
Actively Recruiting
91
Fukuwa Clinic
Chuo-ku, Tokyo, Japan, 104-0031
Actively Recruiting
92
Naoko Dermatology Clinic
Setagaya-ku, Tokyo, Japan, 158-0097
Actively Recruiting
93
Niepubliczny Zakład Opieki Zdrowotnej Zespół Poradni Specjalistycznych "Termedica"
Poznan, Greater Poland Voivodeship, Poland, 60-681
Actively Recruiting
94
Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, Poland, 30-727
Actively Recruiting
95
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
Wroclaw, Lower Silesian Voivodeship, Poland, 50-381
Actively Recruiting
96
Centrum Medyczne Angelius Provita
Katowice, Silesian Voivodeship, Poland, 40-611
Actively Recruiting
97
Synexus Polska Sp. z o.o. Oddzial w Katowicach
Katowice, Poland, 40-040
Actively Recruiting
98
Dermedic Jacek Zdybski
Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, Poland, 27-400
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
14
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