Actively Recruiting
An Open-label, Randomized Study to Compare Bimekizumab Given Intravenously or by Injection in Adults With Active Psoriatic Arthritis or Axial Spondyloarthritis
Led by UCB Biopharma SRL · Updated on 2026-06-05
392
Participants Needed
61
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial investigates adults with active psoriatic arthritis or active axial spondyloarthritis to compare two ways of giving the drug bimekizumab: intravenously (IV) or by subcutaneous (under the skin) injection. The study aims to show that intravenous administration is not less effective than subcutaneous administration in how the drug moves through the body. It is an open-label, randomized, Phase 1 study sponsored by UCB Biopharma SRL focused on pharmacokinetics and safety.
CONDITIONS
Brief Title
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 years old or older and legally able to consent
- Have active psoriatic arthritis or active axial spondyloarthritis suitable for bimekizumab treatment
- Weigh between 45-100 kg for females or 50-100 kg for males
- Be biologic disease-modifying anti-rheumatic drug (bDMARD)-nafve or have stopped bDMARDs at least 3 months or 5 half-lives ago
You will not qualify if you...
- Have serious disorders of the heart, liver, kidney, gastrointestinal system, or nervous system
- Have severe psychiatric issues or substance abuse within the past year
- Have recent or chronic infections including tuberculosis or nontuberculous mycobacterium
- Have other inflammatory diseases such as rheumatoid arthritis, lupus, or inflammatory bowel disease
- Have had live vaccines within 8 weeks or Bacillus Calmette-Guerin (BCG) vaccine within 1 year
- Have used glucagon-like peptide-1 agonists within the last 28 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants receive assigned bimekizumab dosing regimen during the PK Lead-In Phase.
Duration - Up to 16 weeks
Participants receive assigned bimekizumab dosing regimen during the Treatment Period.
Duration - Up to 13 weeks after treatment
Participants are monitored for treatment-emergent adverse events after treatment ends.
Trial Site Locations
Total: 61 locations
1
Pa0019 114
Peoria, Arizona, United States, 85381-5025
Actively Recruiting
2
Pa0019 127
Apple Valley, California, United States, 92307
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3
Pa0019 111
Covina, California, United States, 91722
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4
Pa0019 117
Riverside, California, United States, 92518
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5
Pa0019 125
San Leandro, California, United States, 94578
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6
Pa0019 126
Temecula, California, United States, 92592
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7
Pa0019 141
Upland, California, United States, 91786
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8
Pa0019 120
Whittier, California, United States, 90602
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9
Pa0019 128
Whittier, California, United States, 90602
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10
Pa0019 123
Fort Collins, Colorado, United States, 80528
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11
Pa0019 143
Ormond Beach, Florida, United States, 32174
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12
Pa0019 113
South Miami, Florida, United States, 33155
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13
Pa0019 132
Chicago, Illinois, United States, 60661
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14
Pa0019 134
Lansing, Michigan, United States, 48911
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15
Pa0019 140
West Long Branch, New Jersey, United States, 07764-1503
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16
Pa0019 131
Albuquerque, New Mexico, United States, 87102
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17
Pa0019 144
Vandalia, Ohio, United States, 45377
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18
Pa0019 115
Duncansville, Pennsylvania, United States, 16635
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19
Pa0019 142
Rock Hill, South Carolina, United States, 29732
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20
Pa0019 116
Jackson, Tennessee, United States, 38305
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21
Pa0019 138
Murfreesboro, Tennessee, United States, 37128
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22
Pa0019 129
Baytown, Texas, United States, 77521
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23
Pa0019 136
Colleyville, Texas, United States, 76034
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24
Pa0019 135
Mesquite, Texas, United States, 75150
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25
Pa0019 124
Plano, Texas, United States, 75075
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26
Pa0019 121
Bellevue, Washington, United States, 98004
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27
Pa0019 145
Spokane, Washington, United States, 99216
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28
Pa0019 130
Beckley, West Virginia, United States, 25801
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29
Pa0019 204
Lovech, Bulgaria
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30
Pa0019 205
Pleven, Bulgaria
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31
Pa0019 201
Plovdiv, Bulgaria
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32
Pa0019 202
Plovdiv, Bulgaria
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33
Pa0019 203
Plovdiv, Bulgaria
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34
Pa0019 705
Brno, Czechia
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35
Pa0019 703
Hlučín, Czechia
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36
Pa0019 704
Ostrava, Czechia
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37
Pa0019 702
Uherské Hradiště, Czechia
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38
Pa0019 305
Berlin, Germany
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39
Pa0019 301
Hamburg, Germany
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40
Pa0019 302
Ratingen, Germany
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41
Pa0019 306
Wetzlar, Germany
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42
Pa0019 407
Bialystok, Poland
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43
Pa0019 418
Bialystok, Poland
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44
Pa0019 404
Bytom, Poland
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45
Pa0019 401
Elblag, Poland
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46
Pa0019 412
Krakow, Poland
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47
Pa0019 402
Lodz, Poland
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48
Pa0019 410
Lublin, Poland
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49
Pa0019 413
Nowa Sól, Poland
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50
Pa0019 417
Olsztyn, Poland
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51
Pa0019 406
Poznan, Poland
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52
Pa0019 408
Poznan, Poland
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53
Pa0019 411
Poznan, Poland
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54
Pa0019 415
Płońsk, Poland
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55
Pa0019 416
Torun, Poland
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56
Pa0019 405
Warsaw, Poland
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57
Pa0019 409
Warsaw, Poland
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58
Pa0019 414
Warsaw, Poland
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59
Pa0019 420
Wroclaw, Poland
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60
Pa0019 601
Košice, Slovakia
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61
Pa0019 603
Piešťany, Slovakia
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Research Team
U
UCB Cares
U
UCB Cares
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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