Actively Recruiting
A Non-interventional Observational Study Evaluating Treatment Patterns and Safety of Avacincaptad Pegol in Patients with Geographic Atrophy Secondary to Age-related Macular Degeneration
Led by Astellas Pharma Global Development, Inc. · Updated on 2026-06-08
500
Participants Needed
65
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on people with geographic atrophy caused by age-related macular degeneration (AMD). AMD damages the macula, the light-sensitive part of the retina, leading to worsening central vision. Geographic atrophy is an advanced form where retinal cells waste away, potentially causing permanent vision loss. The study observes how patients with this condition are treated in regular medical practice, especially those receiving avacincaptad pegol, a US-approved treatment for geographic atrophy. Participants in this observational study have already decided with their doctors to begin treatment with avacincaptad pegol via intravitreal injection. The study does not assign treatment but collects information on how this drug is used, monitoring patients over time. This includes tracking treatment patterns, safety, and any medical problems linked to avacincaptad pegol. The study runs for about five years, recording ongoing care and treatment decisions. During the study, participants will have routine eye exams and complete surveys about their eye health. Surveys occur at treatment start, every six months for two years, then annually. Researchers will gather data from medical records on the number and frequency of injections, treatment duration, reasons for stopping treatment, and patient characteristics. They will also monitor vision changes and adverse events. This long-term follow-up helps understand real-world use and safety of avacincaptad pegol in geographic atrophy care.
CONDITIONS
Brief Title
A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with geographic atrophy secondary to age-related macular degeneration in one or both eyes
- Decision made to treat with intravitreal avacincaptad pegol before enrollment
- Willingness to complete patient-reported outcome surveys
You will not qualify if you...
- Contraindication or ineligibility for avacincaptad pegol treatment, including active ocular or peri-ocular infection in either eye
- Active or suspected intraocular inflammation in either eye
- Hypersensitivity to avacincaptad pegol or any ingredients in its formulation
- Current participation in investigational programs outside routine clinical practice
- Previous avacincaptad pegol treatment in the eye considered for enrollment
- Previous treatment with any intravitreal complement inhibitor other than avacincaptad pegol without completing a 90-day washout period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 61 months
Participants who undergo routine care with avacincaptad pegol are observed to evaluate treatment patterns and safety.
Visits as part of routine clinical practice
Trial Site Locations
Total: 65 locations
1
Phoenix Retina Clinical Trials, LLC
Phoenix, Arizona, United States, 85050
Actively Recruiting
2
Retinal Consultants of AZ
Phoenix, Arizona, United States, 85053
Actively Recruiting
3
Retina Macula Institute of Arizona
Scottsdale, Arizona, United States, 85255
Actively Recruiting
4
The Retina Partners
Encino, California, United States, 91436
Withdrawn
5
Harvard Eye Associates
Laguna Hills, California, United States, 92653
Actively Recruiting
6
University of California Irvine Medical Center
Orange, California, United States, 92868
Actively Recruiting
7
Retina Consultants of Southern CA
Redlands, California, United States, 92374
Actively Recruiting
8
Retinal Consultants Medical Group Inc
Sacramento, California, United States, 95825
Actively Recruiting
9
Retina Macula Institute
Torrance, California, United States, 90503
Actively Recruiting
10
Rocky Mountain Lions Eye Institute
Aurora, Colorado, United States, 80045
Actively Recruiting
11
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, United States, 80909
Actively Recruiting
12
Colorado Retina Associates, PLLC
Lakewood, Colorado, United States, 80228
Actively Recruiting
13
Coastal Eye Surgeons
Greenwich, Connecticut, United States, 05830
Actively Recruiting
14
Florida Eye Clinic
Altamonte Springs, Florida, United States, 32701
Withdrawn
15
Advanced Retina Institute
Bonita Springs, Florida, United States, 34134
Actively Recruiting
16
University of Miami
Coral Gables, Florida, United States, 33146
Actively Recruiting
17
Retina Care Specialists
Palm Beach Gardens, Florida, United States, 33410
Actively Recruiting
18
Eye Physicians of Pinellas PA dba Eye Institute of West Florida
Tampa, Florida, United States, 33606
Actively Recruiting
19
Retina Specialists of Tampa
Wesley Chapel, Florida, United States, 33544
Actively Recruiting
20
Southeast Retina Center, P.C.
Augusta, Georgia, United States, 30909
Actively Recruiting
21
University Retina and Macula Associates, P.C.
Oak Forest, Illinois, United States, 60452
Actively Recruiting
22
Illinois Retina Associates
Oak Park, Illinois, United States, 60304
Actively Recruiting
23
Illinois Eye Center
Peoria, Illinois, United States, 61615
Actively Recruiting
24
Wolfe Eye Clinic
West Des Moines, Iowa, United States, 50266
Actively Recruiting
25
Cumberland Valley Retina Consultants,P.C.
Hagerstown, Maryland, United States, 21740
Actively Recruiting
26
Retina Specialists
Towson, Maryland, United States, 21204
Withdrawn
27
Retina Associates of Michigan
Grand Blanc, Michigan, United States, 48439
Actively Recruiting
28
Retina Consultants of Minnesota PLLC
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
29
Mississippi Retina Associates
Madison, Mississippi, United States, 39110
Actively Recruiting
30
Brown Family Retina PLLC
Olive Branch, Mississippi, United States, 38654
Actively Recruiting
31
Deep Blue Retina Clinical Research
Southaven, Mississippi, United States, 38671
Actively Recruiting
32
Sierra Eye Associates
Reno, Nevada, United States, 89502
Actively Recruiting
33
Eye Associates of North Jersey PA
Dover, New Jersey, United States, 07801
Actively Recruiting
34
NJ Retina
Edison, New Jersey, United States, 08820
Actively Recruiting
35
NJ Retina
Lakewood, New Jersey, United States, 08701
Actively Recruiting
36
Monmouth Retina Consultants
Little Silver, New Jersey, United States, 07739
Withdrawn
37
NJ Retina
Toms River, New Jersey, United States, 08755
Actively Recruiting
38
SightMD
Brentwood, New York, United States, 11717
Actively Recruiting
39
Retina-Vitreous Surgeons of Central NY
Liverpool, New York, United States, 13088
Actively Recruiting
40
NY Retina Ophthalmology PLLC
Massapequa, New York, United States, 11758
Active, Not Recruiting
41
Retina Associates of New York
New York, New York, United States, 10075
Active, Not Recruiting
42
Long Island Vitreoretinal Consultants
Scarsdale, New York, United States, 10583
Actively Recruiting
43
Vitreoretinal Consultants
Shirley, New York, United States, 11967
Actively Recruiting
44
North Carolina Retina Associates
Cary, North Carolina, United States, 27511
Withdrawn
45
North Carolina Retina Associates
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
46
The Ohio State University
Columbus, Ohio, United States, 43221
Actively Recruiting
47
CEI Physicians PSC, LLC dba
Dayton, Ohio, United States, 45459
Actively Recruiting
48
Verum Research, LLC
Eugene, Oregon, United States, 97401
Actively Recruiting
49
Erie Retina Research
Erie, Pennsylvania, United States, 16507
Actively Recruiting
50
Southeastern Retina Associates, P.C.
Knoxville, Tennessee, United States, 37920
Actively Recruiting
51
Southeastern Retina Associates, P.C.
Knoxville, Tennessee, United States, 37923
Actively Recruiting
52
Mid South Retina Associates
Memphis, Tennessee, United States, 38119
Actively Recruiting
53
Tennessee Retina, PC
Nashville, Tennessee, United States, 37203
Actively Recruiting
54
Retina Research Institute of Texas
Abilene, Texas, United States, 79606
Actively Recruiting
55
Retina & Vitreous of Texas
Bellaire, Texas, United States, 77401
Withdrawn
56
Retina of North Texas
Dallas, Texas, United States, 75243
Actively Recruiting
57
Valley Retina Institute
McAllen, Texas, United States, 78503
Actively Recruiting
58
Medical Center Ophthalmology Associates
San Antonio, Texas, United States, 78240
Actively Recruiting
59
Retina Associates Of South Texas, Pa
San Antonio, Texas, United States, 78240
Actively Recruiting
60
Retina Associates of Utah, P.C.
Murray, Utah, United States, 84107
Actively Recruiting
61
Salt Lake Retina
Salt Lake City, Utah, United States, 84120
Actively Recruiting
62
The Retina Group of Washington
Fairfax, Virginia, United States, 22031
Actively Recruiting
63
Piedmont Eye Center, Inc.
Lynchburg, Virginia, United States, 24502
Actively Recruiting
64
Virginia Retina Center
Warrenton, Virginia, United States, 20186
Actively Recruiting
65
Retina & Vitreous Consultants of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Active, Not Recruiting
Research Team
A
Astellas Pharma Global Development, Inc.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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