Actively Recruiting
A Phase 3 Trial Comparing Oral Sevabertinib With Standard Pembrolizumab and Chemotherapy for Advanced NSCLC With HER2 Mutations
Led by Bayer · Updated on 2026-05-18
444
Participants Needed
284
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating better treatments for people with advanced non-small cell lung cancer (NSCLC) that have specific genetic changes called HER2 mutations. This type of lung cancer has spread to nearby tissues or other parts of the body and is hard to control with current treatments. The study focuses on how well sevabertinib, a drug designed to block the faulty HER2 protein, works and how safe it is compared to standard treatments. This is a Phase 3 trial involving participants with confirmed HER2-mutated advanced NSCLC. Participants will be randomly assigned to receive either sevabertinib tablets taken twice daily by mouth or standard treatment, which includes cycles of pembrolizumab combined with platinum-based chemotherapy delivered through an intravenous infusion every 21 days. Those receiving standard treatment who experience disease progression may switch to sevabertinib. Treatment continues as long as participants benefit and do not have severe side effects, or until they or their doctor decide to stop. During the study, participants will have imaging scans such as CT, PET, MRI, and X-rays to monitor cancer spread. Health checks include blood and urine tests, electrocardiograms to assess heart health, and pregnancy tests for women. Participants will be asked about their symptoms and any adverse events, which are medical problems occurring during the study. The main outcome measured is progression-free survival, with other assessments including overall survival and quality of life tracked for up to four years.
CONDITIONS
Brief Title
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be 18 years of age or older or over the legal age of consent where applicable at the time of signing informed consent.
- Confirmed diagnosis of locally advanced or metastatic non-squamous NSCLC (Stage III-IV) not suitable for definitive therapy.
- Documented activating HER2 mutation in the tyrosine kinase domain confirmed by an accredited laboratory.
- No prior systemic therapy for locally advanced or metastatic disease.
- No prior treatment with HER2 exon 20 insertion-targeted therapies.
- Eligible for platinum-based doublet chemotherapy and pembrolizumab according to product information.
You will not qualify if you...
- History of prior malignancy except if disease-free for five years after curative treatment; certain in situ or limited cancers are exceptions.
- Tumors with targetable alterations that have approved therapies, except HER2 mutation in the tyrosine kinase domain.
- Inability to stop chronic systemic corticosteroids; stable replacement therapy is allowed.
- Pre-existing peripheral neuropathy Grade 2 or higher.
- History of severe allergic reaction to monoclonal antibody treatments.
- Radiotherapy outside the brain within 21 days before starting study treatment, with recovery from radiation-related toxicities required.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Until disease progression or discontinuation
Participants receive either oral sevabertinib tablets twice daily or pembrolizumab combined with platinum-based chemotherapy in 21-day cycles until disease progression, unacceptable toxicity, or withdrawal.
Treatment visits every 3 weeks for chemotherapy and pembrolizumab; daily oral dosing for sevabertinib
Duration - Up to approximately 4 years
Participants are monitored for survival, response, and safety outcomes up to approximately 4 years after treatment.
Regular follow-up visits as scheduled by the study team
Trial Site Locations
Total: 284 locations
1
Patty & George Hoag Cancer Center
Newport Beach, California, United States, 92663
Withdrawn
2
UC San Diego Health - Moores Cancer Center
San Diego, California, United States, 92037
Actively Recruiting
3
UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology
San Francisco, California, United States, 94158
Actively Recruiting
4
UCLA Health Santa Monica Cancer Care
Santa Monica, California, United States, 90404
Actively Recruiting
5
The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street
Fort Lauderdale, Florida, United States, 33316
Actively Recruiting
6
Memorial Cancer Institute at Miramar
Miramar, Florida, United States, 33029
Actively Recruiting
7
AdventHealth Cancer Institute Orlando
Orlando, Florida, United States, 32804
Actively Recruiting
8
Moffitt Cancer Center - Magnolia Campus
Tampa, Florida, United States, 33612
Actively Recruiting
9
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Not Yet Recruiting
10
Piedmont Healthcare - Atlanta
Atlanta, Georgia, United States, 30318
Actively Recruiting
11
John B. Amos Cancer Center
Columbus, Georgia, United States, 31904
Actively Recruiting
12
University of Illinois Hospital - Outpatient Cancer Care Center
Chicago, Illinois, United States, 60612
Actively Recruiting
13
The University of Chicago Medical Center - Hyde Park - Hematology & Oncology
Chicago, Illinois, United States, 60637
Actively Recruiting
14
UM Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
15
UMass Memorial Medical Center - University Campus - Hematology/Oncology
Worcester, Massachusetts, United States, 01655-0002
Withdrawn
16
Profound Research -OMG - TriAtria Cancer Center
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
17
Profound Research - OMG - Royal Oak Cancer Center
Royal Oak, Michigan, United States, 48073
Actively Recruiting
18
M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
19
R.J. Zuckerberg Cancer Center
New Hyde Park, New York, United States, 11042
Withdrawn
20
UC Medical Center - Oncology
Cincinnati, Ohio, United States, 45219
Actively Recruiting
21
Taylor Cancer Research Center
Maumee, Ohio, United States, 43537
Actively Recruiting
22
Providence Cancer Institute - Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
23
Providence Oncology and Hematology Care Clinic Westside
Portland, Oregon, United States, 97225
Actively Recruiting
24
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
25
University Hospital Simmons Cancer Center Lung/Head Neck Clinic
Dallas, Texas, United States, 75235
Withdrawn
26
The University of Texas MD Anderson Cancer Center - Texas Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
27
VCU Health Ambulatory Care Center - Cardiology
Richmond, Virginia, United States, 23298
Withdrawn
28
Fundación Cenit para la Investigación en Neurociencias
CABA, Ciudad Auton. de Buenos Aires, Argentina, C1125 ABD
Withdrawn
29
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina, C1199ABB
Withdrawn
30
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)
Buenos Aires, Argentina, C1431FWO
Withdrawn
31
Centro Médico Privado CEMAIC
Córdoba, Argentina, X5008HHW
Withdrawn
32
Instituto Argentino de Diagnostico y Tratamiento (IADT)
TBC, Argentina, TBC
Withdrawn
33
Centro de Investigaciones Clínicas, Clínica Viedma
Viedma, Argentina, R8500
Withdrawn
34
NSW Health - Blacktown Hospital
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
35
Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit
Concord, New South Wales, Australia, 2139
Actively Recruiting
36
Calvary Mater Hospital Newcastle - Oncology
Waratah, New South Wales, Australia, 2298
Actively Recruiting
37
University of the Sunshine Coast
Buderim, Queensland, Australia, 4556
Actively Recruiting
38
Toowoomba Hospital Oncology Clinical Trials
Toowoomba, Queensland, Australia, 4350
Not Yet Recruiting
39
Austin Hospital - Olivia Newton John Cancer Research Institute
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
40
The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC)
Garran, Australia, 2605
Not Yet Recruiting
41
Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III
Vienna, State of Salzburg, Austria, 1090
Actively Recruiting
42
Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde
Vienna, State of Salzburg, Austria, 1090
Actively Recruiting
43
Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie
Vienna, State of Vienna, Austria, 1090
Actively Recruiting
44
Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik
Vienna, Austria, 1210
Actively Recruiting
45
UZ Leuven Gasthuisberg - Pneumology Department
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
46
AZ Delta | Clinical Trial Center - Pneumology
Roeselare, West-Flanders, Belgium, 8800
Actively Recruiting
47
Antwerp University Hospital | Oncology Department
Antwerp, Belgium, 2650
Actively Recruiting
48
Pronutrir Fortaleza - CE
Fortaleza, Ceará, Brazil, 60810-180
Actively Recruiting
49
Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima
Brasília, Federal District, Brazil, 04538-132
Actively Recruiting
50
Rede DoR Recife - PE
Recife, Pernambuco, Brazil, 50070-480
Actively Recruiting
51
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica
Natal, Rio Grande do Norte, Brazil, 59040-000
Actively Recruiting
52
Centro de Pesquisa da Clínica de Oncologia Reichow
Blumenau, Santa Catarina, Brazil, 89010-340
Actively Recruiting
53
NAIC - Instituto do Cancer
Bauru, São Paulo, Brazil, 17033-490
Actively Recruiting
54
Fundacao Pio XII - Hospital de Cancer de Barretos
Jaú, São Paulo, Brazil, 14784-400
Actively Recruiting
55
Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia
São José do Rio Preto, São Paulo, Brazil, 15090-000
Withdrawn
56
Hospital Sirio Libanes
São Paulo, São Paulo, Brazil, 01308-050
Actively Recruiting
57
A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante
São Paulo, São Paulo, Brazil, 01323-030
Actively Recruiting
58
Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia
São Paulo, São Paulo, Brazil, 71635-610
Actively Recruiting
59
Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology
São Paulo, São Paulo, Brazil, 90020-090
Actively Recruiting
60
MHAT Uni Hospital
Panagyurishte, Pazardzhik Province, Bulgaria, 4500
Actively Recruiting
61
MHAT "Heart and brain" Pleven
Pleven, Pleven Province, Bulgaria, 5804
Actively Recruiting
62
Complex Oncology Center - Plovdiv EOOD
Plovdiv, Plovdiv Province, Bulgaria, 4004
Actively Recruiting
63
MHAT Park Hospital EOOD
Plovdiv, Plovdiv Province, Bulgaria, 4109
Withdrawn
64
Multiprofile Hospital for Active Treatment "Sveta Sofia"
Sofia, Sofia City Province, Bulgaria, 1404
Actively Recruiting
65
MHAT Serdika
Sofia, Sofia City Province, Bulgaria, 1632
Actively Recruiting
66
Specialized Hospital for Active Treatment of Oncology
Sofia, Sofia City Province, Bulgaria, 1797
Withdrawn
67
University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia
Sofia, Sofia City Province, Bulgaria, 1797
Actively Recruiting
68
MHAT Sveta Marina EAD
Varna, Varna Province, Bulgaria, 9010
Actively Recruiting
69
BC Cancer | Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
70
Brampton Civic Hospital | Oncology
Brampton, Ontario, Canada, L6R 3J7
Actively Recruiting
71
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
72
Jewish General Hospital | Pulmonary Oncology
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
73
Beijing Cancer Hospital - Oncology Department
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
74
Beijing Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
75
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Actively Recruiting
76
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150000
Withdrawn
77
Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech
Wuhan, Hubei, China, 430023
Actively Recruiting
78
Hubei Cancer Hospital
Wuhan, Hubei, China, 430079
Actively Recruiting
79
Hunan Cancer Hospital - Oncology Department
Changsha, Hunan, China, 410013
Actively Recruiting
80
NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
Nanjing, Jiangsu, China, 210008
Actively Recruiting
81
Jilin Cancer Hospital
Changchun, Jilin, China, 130000
Actively Recruiting
82
Shanghai Chest Hospital, Shanghai Jiaotong University
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
83
West China Hospital Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
84
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department
Hangzhou, Zhejiang, China, 310016
Actively Recruiting
85
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
86
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China, 317000
Actively Recruiting
87
Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, China, 100000
Actively Recruiting
88
The People's Liberation Army General Hospital (Beijing 301 Hospital)
Beijing, China, 100853
Actively Recruiting
89
Beijing chest hospital, Capital Medical University
Beijing, China, 101149
Actively Recruiting
90
University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital)
Chengdu, China, 610041
Actively Recruiting
91
The first Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510230
Actively Recruiting
92
Shandong University - Shandong Cancer Hospital
Jinan, China, 250117
Actively Recruiting
93
LinYi Cancer Hospital (Linyi Tumor Hospital)
Linyi, China, 276001
Actively Recruiting
94
Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University
Nanjing, China, 210029
Actively Recruiting
95
Guangxi Medical University (GXMU) - Affiliated Tumor Hospital
Nanning, China, 530021
Actively Recruiting
96
Zhongshan Hospital, Fudan University
Shanghai, China, 200032
Actively Recruiting
97
Xiamen University - The First Affiliated Hospital
Xiamen, China, 361003
Actively Recruiting
98
Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie
Zlín, Zlín, Czechia, 762 75
Actively Recruiting
99
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP)
Brno, Czechia, 602 00
Actively Recruiting
100
Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie
Nový Jicín, Czechia, 741 01
Actively Recruiting
101
Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy
Olomouc, Czechia, 77900
Withdrawn
102
Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení
Ostrava - Vítkovice, Czechia, 703 00
Actively Recruiting
103
Rigshospitalet - Kræftbehandling
Copenhagen, Capital Region, Denmark, 2100
Actively Recruiting
104
Aarhus Universitetshospital
Aarhus N, Central Jutland, Denmark, 8200
Actively Recruiting
105
Regionshospitalet Gødstrup - Medicinsk afdeling
Herning, Central Jutland, Denmark, 7400
Withdrawn
106
Aalborg University hospital - oncology department
Aalborg, North Denmark, Denmark, 9000
Actively Recruiting
107
Odense University Hospital - Oncology Department
Odense, Region Syddanmark, Denmark, 5000
Actively Recruiting
108
Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Keuhkosairauksien poliklinikka
Turku, Southwest Finland, Finland, 20520
Actively Recruiting
109
Docrates Mehiläinen Syöpäsairaala
Helsinki, Uusimaa, Finland, 00180
Actively Recruiting
110
Centre Hospitalier Michallon Grenoble - Service pneumologie
La Tronche, Auvergne-Rhône-Alpes, France, 38700
Actively Recruiting
111
hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique
Pierre-Bénite, Auvergne-Rhône-Alpes, France, 69310
Actively Recruiting
112
Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie
Brest, Brittany Region, France, 29200
Actively Recruiting
113
hopital Emile Muller - Service Pneumologie
Mulhouse, Grand Est, France, 68100
Actively Recruiting
114
Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire
Lille, Hauts-de-France, France, 59000
Actively Recruiting
115
Institut Bergonie - Unicancer Nouvelle Aquitaine
Bordeaux, New Aquitaine, France, 33076
Actively Recruiting
116
Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique
Limoges, New Aquitaine, France, 87000
Actively Recruiting
117
CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie
Rouen, Normandy, France, 76031
Withdrawn
118
CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique
Montpellier, Occitanie, France, 34091
Actively Recruiting
119
Hopital Nord Laennec - Oncologie medicale thoracique et digestive
Nantes, Pays de la Loire Region, France, 44093
Actively Recruiting
120
Institut de Cancerologie Ouest - Saint-Herblain
Saint-Herblain, Pays de la Loire Region, France, 44800
Actively Recruiting
121
Centre Antoine Lacassagne - Departement Oncologie
Nice, Provence-Alpes-Côte d'Azur Region, France, 06100
Actively Recruiting
122
Centre Hospitalier Intercommunal Creteil - Service de pneumologie
Créteil, Île-de-France Region, France, 94010
Actively Recruiting
123
hopital cochin APHP - service de pneumologie
Paris, Île-de-France Region, France, 75014
Withdrawn
124
Institut Curie - Paris - Oncologie medicale
Paris, Île-de-France Region, France, 75248
Actively Recruiting
125
Hopital Foch - Oncologie digestive et thoracique
Suresnes, Île-de-France Region, France, 92150
Actively Recruiting
126
Gustave Roussy - Departement Oncologie-Radiotherapie
Villejuif, Île-de-France Region, France, 94800
Actively Recruiting
127
Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie
Giessen, Hesse, Germany, 35392
Actively Recruiting
128
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik
Cologne, North Rhine-Westphalia, Germany, 51109
Actively Recruiting
129
Universitaetsklinikum Essen - Innere Klinik (Tumorforschung)
Essen, North Rhine-Westphalia, Germany, 45122
Actively Recruiting
130
Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie
Berlin, Germany, 12203
Actively Recruiting
131
Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie
Frankfurt, Germany, 60590
Actively Recruiting
132
Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin
Hemer, Germany, 58675
Actively Recruiting
133
Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde)
Nuremberg, Germany, 90419
Actively Recruiting
134
Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin
Stuttgart, Germany, 70376
Actively Recruiting
135
University General Hospital Attikon-4th Department of Internal Medicine
Chaïdári, Attica, Greece, 12462
Actively Recruiting
136
Genesis Hospital- Department of Pathological Oncology
Pylaia Thessaloniki, Thessaloniki, Greece, 555 35
Actively Recruiting
137
?enry Dunant Hospital Center-4th Oncology Department and Clinical Trials Unit
Athens, Greece, 11526
Actively Recruiting
138
Thoracic General Hospital Of Athens I Sotiria-3rd University Department of Internal Medicine
Athens, Greece, 11527
Actively Recruiting
139
General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA
Athens, Greece, 11528
Actively Recruiting
140
University General Hospital Attikon, 2nd Department of Propaedeutic and Internal Medicine
Athens, Greece, 12462
Actively Recruiting
141
General University Hospital Of Larissa-Department of Medical Oncology
Larissa, Greece, 41110
Actively Recruiting
142
Metropolitan Hospital- 4th Oncology Clinic
Piraeus, Greece, 18547
Withdrawn
143
Geniko Nosokomeio Thessalonikis George Papanikolaou-Pulmonary Department
Thessaloniki, Greece, 57010
Actively Recruiting
144
Prince of Wales Hospital
Hong Kong, Hong Kong SAR, Hong Kong, 00000
Actively Recruiting
145
Queen Elizabeth Hospital Hong Kong
Hong Kong, Hong Kong SAR, Hong Kong, 00000
Actively Recruiting
146
Queen Mary Hospital
Hong Kong, Hong Kong SAR, Hong Kong, 00000
Actively Recruiting
147
Hong Kong United Oncology Centre
Kowloon, Hong Kong, 00000
Actively Recruiting
148
Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály
Budapest, Hungary, 1145
Actively Recruiting
149
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
Tatabánya, Hungary, 2800
Withdrawn
150
Assuta Ashdod Public Hospital (R.A)
Ashdod, Israel, 7747629
Actively Recruiting
151
Soroka Medical Center- Legacy Heritage Cancer Center
Beersheba, Israel, 8410101
Actively Recruiting
152
Shaare Zedek Medical Center (SZMC)
Jerusalem, Israel, 91031
Actively Recruiting
153
Tel-Aviv Sourasky Medical Center
Tel Aviv, Israel, 6423906
Actively Recruiting
154
AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica
Avellino, Campania, Italy, 83100
Actively Recruiting
155
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica
Bologna, Emilia-Romagna, Italy, 40138
Actively Recruiting
156
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica
Meldola, Emilia-Romagna, Italy, 47014
Actively Recruiting
157
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati
Aviano, Friuli Venezia Giulia, Italy, 33081
Actively Recruiting
158
I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2
Rome, Lazio, Italy, 00144
Actively Recruiting
159
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare
Rome, Lazio, Italy, 00168
Actively Recruiting
160
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1
Milan, Lombardy, Italy, 20133
Actively Recruiting
161
Istituto Europeo di Oncologia s.r.l - Oncologia Toracica
Milan, Lombardy, Italy, 20141
Actively Recruiting
162
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia
Rozzano, Lombardy, Italy, 20089
Actively Recruiting
163
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica
Orbassano, Piedmont, Italy, 10043
Actively Recruiting
164
Istituto Oncologico Veneto_Padova - UOC Oncologia 2
Padova, Veneto, Italy, 35128
Actively Recruiting
165
Careggi University Hospital - Oncologia Clinica
Florence, Italy, 50134
Not Yet Recruiting
166
Careggi University Hospital - Oncologia Clinica
Florence, Italy, 50134
Actively Recruiting
167
Ospedale Vito Fazzi Lecce - Oncologia
Lecce, Italy, 73100
Actively Recruiting
168
Ospedale San Raffaele s.r.l. - Oncologia Medica
Milan, Italy, 20132
Actively Recruiting
169
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica
Palermo, Italy, 90146
Actively Recruiting
170
ASST Sette Laghi_Ospedale Macchi - Oncologia
Varese, Italy, 21100
Withdrawn
171
Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia
Verona, Italy, 37134
Actively Recruiting
172
National Hospital Organization Nagoya Medical Center
Nagoya, Aichi-ken, Japan, 460-0001
Actively Recruiting
173
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Actively Recruiting
174
Hokkaido University Hospital
Sapporo, Hokkaido, Japan, 060-8648
Actively Recruiting
175
National Hospital Organization Himeji Medical Center
Himeji, Hyōgo, Japan, 670-8520
Actively Recruiting
176
Kobe University Hospital
Kobe, Hyōgo, Japan, 650-0017
Actively Recruiting
177
Kitasato University Hospital
Sagamihara, Kanagawa, Japan, 252-0375
Actively Recruiting
178
Sendai Kousei Hospital
Sendai, Miyagi, Japan, 980-0873
Actively Recruiting
179
Kansai Medical University Hospital
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
180
Kindai University Hospital
Sakai, Osaka, Japan, 590-0197
Actively Recruiting
181
Saitama Cancer Center
Kitaadachi-gun, Saitama, Japan, 362-0806
Actively Recruiting
182
Nippon Medical School - Nippon Medical School Hospital - Cancer Center
Bunkyo-ku, Tokyo, Japan, 113-8603
Actively Recruiting
183
Tottori University Hospital
Yonago, Tottori, Japan, 683-8504
Actively Recruiting
184
National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital)
Ube, Yamaguchi, Japan, 755-0241
Actively Recruiting
185
National Hospital Organization Kyushu Medical Center
Fukuoka, Japan, 810-8563
Actively Recruiting
186
Niigata Cancer Center Hospital
Niigata, Japan, 951-8566
Actively Recruiting
187
Osaka International Cancer Institute
Osaka, Japan, 541-8567
Actively Recruiting
188
Universiti Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, Malaysia, 59100
Actively Recruiting
189
University Hospital Kebangsaan Malaysia
Cheras, Kuala Lumpur and Selangor, Malaysia, 56000
Withdrawn
190
Gleneagles Penang Medical Center
George Town, Pulau Pinang, Malaysia, 10050
Actively Recruiting
191
Sunway Medical Centre Penang
Perai, Pulau Pinang, Malaysia, 13700
Actively Recruiting
192
Beacon Hospital
Petaling Jaya, Selangor, Malaysia, 46050
Actively Recruiting
193
Columbia Asia Hospital Bukit Rimau
Shah Alam, Selangor, Malaysia, 40460
Actively Recruiting
194
Sunway Medical Centre
Subang Jaya, Selangor, Malaysia, 47500
Actively Recruiting
195
Instituto Nacional de Cancerología
Mexico City, Mexico City, Mexico, 14080
Actively Recruiting
196
Oncare Viaducto Nápoles
Mexico City, Mexico, 3810
Actively Recruiting
197
Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia
Monterrey, Mexico, 64460
Actively Recruiting
198
Oncología Integral Satélite
Naucalpan, Mexico, 53100
Actively Recruiting
199
Clinica Integral Internacional de Oncologia S. de R.L. de C.V.
Puebla City, Mexico, 72530
Actively Recruiting
200
ONCARE Treatment Center
San Pedro Garza García, Mexico, 66220
Actively Recruiting
201
Radboud University Medical Center | Afdeling Interne Geneeskunde
Nijmegen, Gelderland, Netherlands, 6500 HB
Withdrawn
202
Nederlands Kanker Instituut
Amsterdam, North Holland, Netherlands, 1066 CX
Actively Recruiting
203
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej
Warsaw, Masovian Voivodeship, Poland, 02-781
Not Yet Recruiting
204
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej
Warsaw, Masovian Voivodeship, Poland, 02-781
Withdrawn
205
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Poland, 15-276
Withdrawn
206
Swietokrzyskie Centrum Onkologii
Kielce, Poland, 25-734
Actively Recruiting
207
Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
Lodz, Poland, 92-213
Completed
208
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku
Otwock, Poland, 05-400
Completed
209
Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Poznan, Poland, 60-569
Actively Recruiting
210
Instytut Gruzlicy i Chorob Pluc
Warsaw, Poland, 01-138
Withdrawn
211
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii
Wroclaw, Poland, 53-413
Withdrawn
212
Hospital Pedro Hispano | Clinical Research Center
Matosinhos Municipality, Porto District, Portugal, 4464-513
Actively Recruiting
213
Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Urologia
Coimbra, Portugal, 3004-561
Actively Recruiting
214
Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica
Lisbon, Portugal, 1400-038
Actively Recruiting
215
CHULN - Hospital Pulido Valente
Lisbon, Portugal, 1769-001
Actively Recruiting
216
IPO Porto
Porto, Portugal, 4200-072
Actively Recruiting
217
Radiotherapy Center Cluj SRL
Flore?ti, Comuna Floresti, Romania, 407280
Actively Recruiting
218
Sc Oncolab Srl
Craiova, Dolj, Romania, 200385
Actively Recruiting
219
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II
Bucharest, Romania, 22328
Actively Recruiting
220
Spitalul Clinic Coltea
Bucharest, Romania, 30171
Actively Recruiting
221
CardioMed S.R.L.
Cluj-Napoca, Romania, 400015
Actively Recruiting
222
Institutul Oncologic Prof. Dr. Ion Chiricuta
Cluj-Napoca, Romania, 400015
Actively Recruiting
223
Centrul de Oncologie Sfantul Nectarie
Craiova, Romania, 200745
Actively Recruiting
224
S.C Ovidius Clinical Hospital SRL - Oncology Department
Ovidiu, Romania, 905900
Actively Recruiting
225
Oncocenter
Timișoara, Romania, 300166
Actively Recruiting
226
National Cancer Center Singapore - Oncology Department
Singapore, Singapore, 168583
Not Yet Recruiting
227
Raffles Cancer Centre
Singapore, Singapore, 188770
Actively Recruiting
228
OncoCare Cancer Centre | Gleneagles Medical Centre
Singapore, Singapore, 258499
Actively Recruiting
229
Tan Tock Seng Hospital
Singapore, Singapore, 308433
Actively Recruiting
230
Curie Oncology | Farrer
Singapore, Singapore, 329563
Actively Recruiting
231
POKO Poprad s.r.o.
Poprad, Slovakia, 058 01
Actively Recruiting
232
Fakultna nemocnica Trnava
Trnava, Slovakia, 91775
Actively Recruiting
233
Gyeongsang National University Hospital
Jinju, Gyeongsangnam-do, South Korea, 52727
Actively Recruiting
234
Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, South Korea, 50612
Actively Recruiting
235
Chonnam National University Hwasun Hospital | Pulmonology and Critical Care Medicine
Hwasun Gun, Jeollanam-do, South Korea, 58128
Actively Recruiting
236
Chungbuk National University Hospital
Cheongju-si, North Chungcheong, South Korea, 28644
Actively Recruiting
237
Severance Hospital, Yonsei University Health System - Oncology Department
Seoul, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
238
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 3080
Actively Recruiting
239
Samsung Medical Center - Oncology Department
Seoul, South Korea, 06351
Actively Recruiting
240
St.Vincent's Hospital - Oncology Department
Suwon, South Korea, 16247
Not Yet Recruiting
241
Hospital Germans Trias I Pujol | Oncologia
Badalona, Barcelona, Spain, 08916
Actively Recruiting
242
Hospital Universitario Puerta De Hierro De Majadahonda | Oncologia
Majadahonda, Madrid, Spain, 28222
Actively Recruiting
243
Hospital Universitario De Navarra | Oncologia
Pamplona, Navarre, Spain, 31008
Actively Recruiting
244
Complexo Hospitalario Universitario A Coruna | Oncologia
A Coruña, Spain, 15006
Actively Recruiting
245
Hospital Universitari Dexeus Grupo Quironsalud | Oncologia
Barcelona, Spain, 08028
Actively Recruiting
246
Hospital Universitari Vall D Hebron | Oncologia
Barcelona, Spain, 08035
Actively Recruiting
247
Hospital Clinic De Barcelona | Oncologia
Barcelona, Spain, 08036
Actively Recruiting
248
Hospital General Universitario Gregorio Maranon | Oncologia
Madrid, Spain, 28009
Actively Recruiting
249
Hospital Universitario Ramon Y Cajal | Oncologia
Madrid, Spain, 28034
Actively Recruiting
250
Hospital Universitario Fundacion Jimenez Diaz | Oncologia
Madrid, Spain, 28040
Actively Recruiting
251
Fundacion Instituto Valenciano De Oncologia | Oncologia
Valencia, Spain, 46009
Actively Recruiting
252
Hospital Universitario Y Politecnico La Fe | Oncologia
Valencia, Spain, 46026
Actively Recruiting
253
Skånes Universitetssjukhus - Lund - STROKE UNIT?
Lund, Skåne County, Sweden, 221 85
Actively Recruiting
254
Norrlands Universitetssjukhus Umeå - Cancercentrum
Umeå, Västerbotten County, Sweden, 901 85
Actively Recruiting
255
Kantonsspital Baden
Baden, Canton of Aargau, Switzerland, 5404
Actively Recruiting
256
HFR Freiburg - Kantonsspital
Fribourg, Switzerland, 1708
Actively Recruiting
257
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807377
Actively Recruiting
258
Chung Shan Medical University Hospital
Taichung, Taiwan, 402306
Actively Recruiting
259
Taichung Veterans General Hospital
Taichung, Taiwan, 40705
Actively Recruiting
260
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
261
Chi-Mei Medical Center, Liouyine
Tainan, Taiwan, 73657
Actively Recruiting
262
National Taiwan University Hospital (NTUH) - Cancer Research Center
Taipei, Taiwan, 100225
Actively Recruiting
263
National Taiwan University Hospital
Taipei, Taiwan, 100
Actively Recruiting
264
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
265
Adana Sehir Egitim ve Arastirma Hastanesi
Yüreğir, Adana, Turkey (Türkiye), 1370
Actively Recruiting
266
Ankara Bilkent Sehir Hastanesi
Bilkent Ankara, Ankara, Turkey (Türkiye), 6800
Actively Recruiting
267
Ankara Etlik Sehir Hastanesi
Yenimahalle, Ankara, Turkey (Türkiye), 6170
Actively Recruiting
268
Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi
Kadıköy, Istanbul, Turkey (Türkiye), 34722
Actively Recruiting
269
I.A.Ü. VM Medical Park Florya Hastanesi
Küçükçekmece, Istanbul, Turkey (Türkiye), 34295
Actively Recruiting
270
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
Istanbul, Turkey (Türkiye), 34899
Actively Recruiting
271
Ege Universitesi Tip Fakultesi Hastanesi
Izmir, Turkey (Türkiye), 35100
Actively Recruiting
272
Sakarya Universitesi Egitim ve Arastirma Hastanesi
Sakarya, Turkey (Türkiye), 54100
Actively Recruiting
273
LLC "RDP Ukraine" - Medical Department
Dnipro, Ukraine, 49102
Actively Recruiting
274
Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center
Kropyvnytskyi, Ukraine, 25006
Actively Recruiting
275
Kyiv City Clinical Oncology Center - Department of Chemotherapy #1
Kyiv, Ukraine, 03115
Actively Recruiting
276
Limited Liability Company "MedOffice Group Medical Center"
Kyiv, Ukraine, 03189
Actively Recruiting
277
Medical Center LLC "Verum Expert Clinic"
Kyiv, Ukraine, 3039
Actively Recruiting
278
Regional Medical Oncology Centre_Oncology Chemotherapy Department
Lutsk, Ukraine, 43018
Actively Recruiting
279
Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department
Rivne, Ukraine, 33010
Actively Recruiting
280
MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department
Uzhhorod, Ukraine, 88000
Actively Recruiting
281
Torbay Hospital
Torquay, Devon, United Kingdom, TQ2 7AA
Actively Recruiting
282
Belfast City Hospital
Belfast, Northern Ireland, United Kingdom, BT12 7AB
Withdrawn
283
Royal Surrey County Hospital
Guildford, Surrey, United Kingdom, GU2 7XX
Actively Recruiting
284
Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit
Cardiff, Wales, United Kingdom, CF14 2TL
Actively Recruiting
Research Team
B
Bayer Clinical Trials Contact
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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