Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06452277

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Led by Bayer · Updated on 2026-04-17

444

Participants Needed

283

Research Sites

252 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations. Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building plans (genes) for this protein in cancer cells leads to a production of abnormal HER2 and therefore abnormal cell growth and division. The study treatment, sevabertinib, is expected to block the mutated HER2 protein which may stop the spread of NSCLC. The main purpose of this study is to learn how well sevabertinib works and how safe it is compared with standard treatment, in participants who have advanced NSCLC with specific genetic changes called HER2 mutations. The study participants will receive one of the study treatments: * Sevabertinib twice every day as a tablet by mouth, or * Standard treatment in cycles of 21 days via infusion ("drip") into the vein. * Participants will continue their assigned treatment for as long as they benefit from it and do not experience severe side effects, or until they or their doctor decide to stop treatment. When a participant receiving the standard treatment has their disease get worse (this is called "disease progression"), they may have the opportunity to switch ("cross over") to receive sevabertinib. * Participants who switch to sevabertinib will continue this treatment until their disease gets worse again, they have side effects that are too severe, or they or their doctor decide to stop treatment. During the study, the doctors and their study team will: * take imaging scans, including CT, PET, MRI, and X-rays, of different parts of the body to study the spread of cancer * check the overall health of the participants by performing tests such as blood and urine tests, and checking * heart health using an electrocardiogram (ECG) * perform pregnancy tests for women * ask the participants questions about how they are feeling and what adverse events they are having. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.

CONDITIONS

Official Title

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participant must be 18 years of age or older at the time of informed consent.
  • Diagnosed with locally advanced or metastatic non-squamous NSCLC (Stage III-IV), confirmed by tissue tests.
  • Confirmed activating HER2 mutation in the tyrosine kinase domain by approved molecular testing.
  • No prior systemic therapy for advanced or metastatic disease.
  • No prior treatment with HER2 exon 20 insertion-targeted therapies.
  • Adjuvant or neoadjuvant therapy completed at least 12 months before screening is allowed.
  • Eligible for platinum-based doublet chemotherapy (cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab as per treatment guidelines.
Not Eligible

You will not qualify if you...

  • History of prior malignancy unless treated with no recurrence for 5 years, except certain treated cancers within 5 years (in situ cervix, breast, skin; superficial bladder cancer; limited-stage prostate cancer; basal or squamous skin cancers).
  • Tumors with targetable alterations that have approved therapies, except HER2 mutation in TKD.
  • Unable to stop chronic systemic corticosteroids; intermittent inhaled steroids or local steroid injections allowed.
  • Pre-existing peripheral neuropathy grade 2 or higher.
  • History of severe allergic reaction to monoclonal antibody treatments.
  • Radiotherapy outside the brain within 21 days before starting study treatment, unless recovered and off corticosteroids.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 283 locations

1

Patty & George Hoag Cancer Center

Newport Beach, California, United States, 92663

Withdrawn

2

UC San Diego Health - Moores Cancer Center

San Diego, California, United States, 92037

Actively Recruiting

3

UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology

San Francisco, California, United States, 94158

Actively Recruiting

4

UCLA Health Santa Monica Cancer Care

Santa Monica, California, United States, 90404

Actively Recruiting

5

The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street

Fort Lauderdale, Florida, United States, 33316

Actively Recruiting

6

Memorial Cancer Institute at Miramar

Miramar, Florida, United States, 33029

Actively Recruiting

7

AdventHealth Cancer Institute Orlando

Orlando, Florida, United States, 32804

Actively Recruiting

8

Moffitt Cancer Center - Magnolia Campus

Tampa, Florida, United States, 33612

Actively Recruiting

9

Moffitt Cancer Center

Tampa, Florida, United States, 33612

Not Yet Recruiting

10

Piedmont Healthcare - Atlanta

Atlanta, Georgia, United States, 30318

Actively Recruiting

11

John B. Amos Cancer Center

Columbus, Georgia, United States, 31904

Actively Recruiting

12

University of Illinois Hospital - Outpatient Cancer Care Center

Chicago, Illinois, United States, 60612

Actively Recruiting

13

The University of Chicago Medical Center - Hyde Park - Hematology & Oncology

Chicago, Illinois, United States, 60637

Actively Recruiting

14

UM Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, United States, 21201

Actively Recruiting

15

UMass Memorial Medical Center - University Campus - Hematology/Oncology

Worcester, Massachusetts, United States, 01655-0002

Withdrawn

16

Profound Research -OMG - TriAtria Cancer Center

Farmington Hills, Michigan, United States, 48334

Actively Recruiting

17

Profound Research - OMG - Royal Oak Cancer Center

Royal Oak, Michigan, United States, 48073

Actively Recruiting

18

M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center

Minneapolis, Minnesota, United States, 55455

Actively Recruiting

19

R.J. Zuckerberg Cancer Center

New Hyde Park, New York, United States, 11042

Withdrawn

20

UC Medical Center - Oncology

Cincinnati, Ohio, United States, 45219

Actively Recruiting

21

Providence Cancer Institute - Franz Clinic

Portland, Oregon, United States, 97213

Actively Recruiting

22

Providence Oncology and Hematology Care Clinic Westside

Portland, Oregon, United States, 97225

Actively Recruiting

23

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States, 15212

Actively Recruiting

24

University Hospital Simmons Cancer Center Lung/Head Neck Clinic

Dallas, Texas, United States, 75235

Withdrawn

25

The University of Texas MD Anderson Cancer Center - Texas Medical Center

Houston, Texas, United States, 77030

Actively Recruiting

26

VCU Health Ambulatory Care Center - Cardiology

Richmond, Virginia, United States, 23298

Withdrawn

27

Fundación Cenit para la Investigación en Neurociencias

CABA, Ciudad Auton. de Buenos Aires, Argentina, C1125 ABD

Withdrawn

28

Hospital Italiano de Buenos Aires

Buenos Aires, Argentina, C1199ABB

Withdrawn

29

Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)

Buenos Aires, Argentina, C1431FWO

Withdrawn

30

Centro Médico Privado CEMAIC

Córdoba, Argentina, X5008HHW

Withdrawn

31

Instituto Argentino de Diagnostico y Tratamiento (IADT)

TBC, Argentina, TBC

Withdrawn

32

Centro de Investigaciones Clínicas, Clínica Viedma

Viedma, Argentina, R8500

Withdrawn

33

NSW Health - Blacktown Hospital

Blacktown, New South Wales, Australia, 2148

Actively Recruiting

34

Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit

Concord, New South Wales, Australia, 2139

Actively Recruiting

35

Calvary Mater Hospital Newcastle - Oncology

Waratah, New South Wales, Australia, 2298

Actively Recruiting

36

University of the Sunshine Coast

Buderim, Queensland, Australia, 4556

Actively Recruiting

37

Toowoomba Hospital Oncology Clinical Trials

Toowoomba, Queensland, Australia, 4350

Not Yet Recruiting

38

Austin Hospital - Olivia Newton John Cancer Research Institute

Heidelberg, Victoria, Australia, 3084

Actively Recruiting

39

The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC)

Garran, Australia, 2605

Not Yet Recruiting

40

Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III

Vienna, State of Salzburg, Austria, 1090

Actively Recruiting

41

Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde

Vienna, State of Salzburg, Austria, 1090

Actively Recruiting

42

Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie

Vienna, State of Vienna, Austria, 1090

Actively Recruiting

43

Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik

Vienna, Austria, 1210

Actively Recruiting

44

UZ Leuven Gasthuisberg - Pneumology Department

Leuven, Vlaams-Brabant, Belgium, 3000

Actively Recruiting

45

AZ Delta | Clinical Trial Center - Pneumology

Roeselare, West-Flanders, Belgium, 8800

Actively Recruiting

46

Antwerp University Hospital | Oncology Department

Antwerp, Belgium, 2650

Actively Recruiting

47

Pronutrir Fortaleza - CE

Fortaleza, Ceará, Brazil, 60810-180

Actively Recruiting

48

Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima

Brasília, Federal District, Brazil, 04538-132

Actively Recruiting

49

Rede DoR Recife - PE

Recife, Pernambuco, Brazil, 50070-480

Actively Recruiting

50

Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica

Natal, Rio Grande do Norte, Brazil, 59040-000

Actively Recruiting

51

Centro de Pesquisa da Clínica de Oncologia Reichow

Blumenau, Santa Catarina, Brazil, 89010-340

Actively Recruiting

52

NAIC - Instituto do Cancer

Bauru, São Paulo, Brazil, 17033-490

Actively Recruiting

53

Fundacao Pio XII - Hospital de Cancer de Barretos

Jaú, São Paulo, Brazil, 14784-400

Actively Recruiting

54

Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia

São José do Rio Preto, São Paulo, Brazil, 15090-000

Withdrawn

55

Hospital Sirio Libanes

São Paulo, São Paulo, Brazil, 01308-050

Actively Recruiting

56

A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante

São Paulo, São Paulo, Brazil, 01323-030

Actively Recruiting

57

Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia

São Paulo, São Paulo, Brazil, 71635-610

Actively Recruiting

58

Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology

São Paulo, São Paulo, Brazil, 90020-090

Actively Recruiting

59

MHAT Uni Hospital

Panagyurishte, Pazardzhik Province, Bulgaria, 4500

Actively Recruiting

60

MHAT "Heart and brain" Pleven

Pleven, Pleven Province, Bulgaria, 5804

Actively Recruiting

61

Complex Oncology Center - Plovdiv EOOD

Plovdiv, Plovdiv Province, Bulgaria, 4004

Actively Recruiting

62

MHAT Park Hospital EOOD

Plovdiv, Plovdiv Province, Bulgaria, 4109

Withdrawn

63

Multiprofile Hospital for Active Treatment "Sveta Sofia"

Sofia, Sofia City Province, Bulgaria, 1404

Actively Recruiting

64

MHAT Serdika

Sofia, Sofia City Province, Bulgaria, 1632

Actively Recruiting

65

Specialized Hospital for Active Treatment of Oncology

Sofia, Sofia City Province, Bulgaria, 1797

Not Yet Recruiting

66

University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia

Sofia, Sofia City Province, Bulgaria, 1797

Actively Recruiting

67

MHAT Sveta Marina EAD

Varna, Varna Province, Bulgaria, 9010

Actively Recruiting

68

BC Cancer | Vancouver

Vancouver, British Columbia, Canada, V5Z 4E6

Actively Recruiting

69

Brampton Civic Hospital | Oncology

Brampton, Ontario, Canada, L6R 3J7

Actively Recruiting

70

Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology

Toronto, Ontario, Canada, M5G 2C4

Actively Recruiting

71

Jewish General Hospital - Department of Pulmonary Oncology

Montreal, Quebec, Canada, H3T 1E2

Actively Recruiting

72

Beijing Cancer Hospital - Oncology Department

Beijing, Beijing Municipality, China, 100142

Actively Recruiting

73

Beijing Hospital

Beijing, Beijing Municipality, China, 100730

Actively Recruiting

74

Fujian Cancer Hospital

Fuzhou, Fujian, China, 350014

Actively Recruiting

75

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, China, 150000

Withdrawn

76

Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech

Wuhan, Hubei, China, 430023

Actively Recruiting

77

Hubei Cancer Hospital

Wuhan, Hubei, China, 430079

Actively Recruiting

78

Hunan Cancer Hospital - Oncology Department

Changsha, Hunan, China, 410013

Actively Recruiting

79

NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School

Nanjing, Jiangsu, China, 210008

Actively Recruiting

80

Jilin Cancer Hospital

Changchun, Jilin, China, 130000

Actively Recruiting

81

Shanghai Chest Hospital, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, China, 200030

Actively Recruiting

82

West China Hospital Sichuan University

Chengdu, Sichuan, China, 610041

Actively Recruiting

83

Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department

Hangzhou, Zhejiang, China, 310016

Actively Recruiting

84

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China, 310022

Actively Recruiting

85

Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, China, 317000

Actively Recruiting

86

Cancer Hospital, Chinese Academy of Medical Sciences

Beijing, China, 100000

Actively Recruiting

87

The People's Liberation Army General Hospital (Beijing 301 Hospital)

Beijing, China, 100853

Actively Recruiting

88

Beijing chest hospital, Capital Medical University

Beijing, China, 101149

Actively Recruiting

89

University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital)

Chengdu, China, 610041

Actively Recruiting

90

The first Affiliated Hospital of Guangzhou Medical University

Guangzhou, China, 510230

Actively Recruiting

91

Shandong University - Shandong Cancer Hospital

Jinan, China, 250117

Actively Recruiting

92

LinYi Cancer Hospital (Linyi Tumor Hospital)

Linyi, China, 276001

Actively Recruiting

93

Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University

Nanjing, China, 210029

Actively Recruiting

94

Guangxi Medical University (GXMU) - Affiliated Tumor Hospital

Nanning, China, 530021

Actively Recruiting

95

Zhongshan Hospital, Fudan University

Shanghai, China, 200032

Actively Recruiting

96

Xiamen University - The First Affiliated Hospital

Xiamen, China, 361003

Actively Recruiting

97

Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie

Zlín, Zlín, Czechia, 762 75

Actively Recruiting

98

Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP)

Brno, Czechia, 602 00

Actively Recruiting

99

Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie

Nový Jicín, Czechia, 741 01

Actively Recruiting

100

Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy

Olomouc, Czechia, 77900

Withdrawn

101

Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení

Ostrava - Vítkovice, Czechia, 703 00

Actively Recruiting

102

Rigshospitalet - Kræftbehandling

Copenhagen, Capital Region, Denmark, 2100

Actively Recruiting

103

Aarhus Universitetshospital

Aarhus N, Central Jutland, Denmark, 8200

Actively Recruiting

104

Regionshospitalet Gødstrup - Medicinsk afdeling

Herning, Central Jutland, Denmark, 7400

Withdrawn

105

Aalborg University hospital - oncology department

Aalborg, North Denmark, Denmark, 9000

Actively Recruiting

106

Odense University Hospital - Oncology Department

Odense, Region Syddanmark, Denmark, 5000

Actively Recruiting

107

Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Keuhkosairauksien poliklinikka

Turku, Southwest Finland, Finland, 20520

Actively Recruiting

108

Docrates Mehiläinen Syöpäsairaala

Helsinki, Uusimaa, Finland, 00180

Actively Recruiting

109

Centre Hospitalier Michallon Grenoble - Service pneumologie

La Tronche, Auvergne-Rhône-Alpes, France, 38700

Actively Recruiting

110

hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique

Pierre-Bénite, Auvergne-Rhône-Alpes, France, 69310

Actively Recruiting

111

Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie

Brest, Brittany Region, France, 29200

Actively Recruiting

112

hopital Emile Muller - Service Pneumologie

Mulhouse, Grand Est, France, 68100

Actively Recruiting

113

Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire

Lille, Hauts-de-France, France, 59000

Actively Recruiting

114

Institut Bergonie - Unicancer Nouvelle Aquitaine

Bordeaux, New Aquitaine, France, 33076

Actively Recruiting

115

Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique

Limoges, New Aquitaine, France, 87000

Actively Recruiting

116

CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie

Rouen, Normandy, France, 76031

Withdrawn

117

CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique

Montpellier, Occitanie, France, 34091

Actively Recruiting

118

Hopital Nord Laennec - Oncologie medicale thoracique et digestive

Nantes, Pays de la Loire Region, France, 44093

Actively Recruiting

119

Institut de Cancerologie Ouest - Saint-Herblain

Saint-Herblain, Pays de la Loire Region, France, 44800

Actively Recruiting

120

Centre Antoine Lacassagne - Departement Oncologie

Nice, Provence-Alpes-Côte d'Azur Region, France, 06100

Not Yet Recruiting

121

Centre Hospitalier Intercommunal Creteil - Service de pneumologie

Créteil, Île-de-France Region, France, 94010

Actively Recruiting

122

hopital cochin APHP - service de pneumologie

Paris, Île-de-France Region, France, 75014

Actively Recruiting

123

Institut Curie - Paris - Oncologie medicale

Paris, Île-de-France Region, France, 75248

Actively Recruiting

124

Hopital Foch - Oncologie digestive et thoracique

Suresnes, Île-de-France Region, France, 92150

Actively Recruiting

125

Gustave Roussy - Departement Oncologie-Radiotherapie

Villejuif, Île-de-France Region, France, 94800

Actively Recruiting

126

Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie

Giessen, Hesse, Germany, 35392

Actively Recruiting

127

Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik

Cologne, North Rhine-Westphalia, Germany, 51109

Actively Recruiting

128

Universitaetsklinikum Essen - Innere Klinik (Tumorforschung)

Essen, North Rhine-Westphalia, Germany, 45122

Actively Recruiting

129

Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie

Berlin, Germany, 12203

Actively Recruiting

130

Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie

Frankfurt, Germany, 60590

Actively Recruiting

131

Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin

Hemer, Germany, 58675

Actively Recruiting

132

Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde)

Nuremberg, Germany, 90419

Actively Recruiting

133

Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin

Stuttgart, Germany, 70376

Actively Recruiting

134

University General Hospital Attikon-4th Department of Internal Medicine

Chaïdári, Attica, Greece, 12462

Actively Recruiting

135

Genesis Hospital- Department of Pathological Oncology

Pylaia Thessaloniki, Thessaloniki, Greece, 555 35

Actively Recruiting

136

?enry Dunant Hospital Center-4th Oncology Department and Clinical Trials Unit

Athens, Greece, 11526

Actively Recruiting

137

Thoracic General Hospital Of Athens I Sotiria-3rd University Department of Internal Medicine

Athens, Greece, 11527

Actively Recruiting

138

General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA

Athens, Greece, 11528

Actively Recruiting

139

University General Hospital Attikon, 2nd Department of Propaedeutic and Internal Medicine

Athens, Greece, 12462

Actively Recruiting

140

General University Hospital Of Larissa-Department of Medical Oncology

Larissa, Greece, 41110

Actively Recruiting

141

Metropolitan Hospital- 4th Oncology Clinic

Piraeus, Greece, 18547

Withdrawn

142

Geniko Nosokomeio Thessalonikis George Papanikolaou-Pulmonary Department

Thessaloniki, Greece, 57010

Actively Recruiting

143

Prince of Wales Hospital

Hong Kong, Hong Kong SAR, Hong Kong, 00000

Actively Recruiting

144

Queen Elizabeth Hospital Hong Kong

Hong Kong, Hong Kong SAR, Hong Kong, 00000

Actively Recruiting

145

Queen Mary Hospital

Hong Kong, Hong Kong SAR, Hong Kong, 00000

Actively Recruiting

146

Hong Kong United Oncology Centre

Kowloon, Hong Kong, 00000

Actively Recruiting

147

Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály

Budapest, Hungary, 1145

Actively Recruiting

148

Komarom-Esztergom Varmegyei Szent Borbala Korhaz

Tatabánya, Hungary, 2800

Withdrawn

149

Assuta Ashdod Public Hospital (R.A)

Ashdod, Israel, 7747629

Actively Recruiting

150

Soroka Medical Center- Legacy Heritage Cancer Center

Beersheba, Israel, 8410101

Actively Recruiting

151

Shaare Zedek Medical Center (SZMC)

Jerusalem, Israel, 91031

Actively Recruiting

152

Tel-Aviv Sourasky Medical Center

Tel Aviv, Israel, 6423906

Actively Recruiting

153

AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica

Avellino, Campania, Italy, 83100

Actively Recruiting

154

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica

Bologna, Emilia-Romagna, Italy, 40138

Actively Recruiting

155

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica

Meldola, Emilia-Romagna, Italy, 47014

Actively Recruiting

156

Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati

Aviano, Friuli Venezia Giulia, Italy, 33081

Actively Recruiting

157

I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2

Rome, Lazio, Italy, 00144

Actively Recruiting

158

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare

Rome, Lazio, Italy, 00168

Actively Recruiting

159

Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1

Milan, Lombardy, Italy, 20133

Actively Recruiting

160

Istituto Europeo di Oncologia s.r.l - Oncologia Toracica

Milan, Lombardy, Italy, 20141

Actively Recruiting

161

Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia

Rozzano, Lombardy, Italy, 20089

Actively Recruiting

162

Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica

Orbassano, Piedmont, Italy, 10043

Actively Recruiting

163

Istituto Oncologico Veneto_Padova - UOC Oncologia 2

Padova, Veneto, Italy, 35128

Actively Recruiting

164

Careggi University Hospital - Oncologia Clinica

Florence, Italy, 50134

Not Yet Recruiting

165

Careggi University Hospital - Oncologia Clinica

Florence, Italy, 50134

Actively Recruiting

166

Ospedale Vito Fazzi Lecce - Oncologia

Lecce, Italy, 73100

Actively Recruiting

167

Ospedale San Raffaele s.r.l. - Oncologia Medica

Milan, Italy, 20132

Actively Recruiting

168

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica

Palermo, Italy, 90146

Actively Recruiting

169

ASST Sette Laghi_Ospedale Macchi - Oncologia

Varese, Italy, 21100

Withdrawn

170

Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia

Verona, Italy, 37134

Actively Recruiting

171

National Hospital Organization Nagoya Medical Center

Nagoya, Aichi-ken, Japan, 460-0001

Actively Recruiting

172

National Cancer Center Hospital East

Kashiwa, Chiba, Japan, 277-8577

Actively Recruiting

173

Hokkaido University Hospital

Sapporo, Hokkaido, Japan, 060-8648

Actively Recruiting

174

National Hospital Organization Himeji Medical Center

Himeji, Hyōgo, Japan, 670-8520

Actively Recruiting

175

Kobe University Hospital

Kobe, Hyōgo, Japan, 650-0017

Actively Recruiting

176

Kitasato University Hospital

Sagamihara, Kanagawa, Japan, 252-0375

Actively Recruiting

177

Sendai Kousei Hospital

Sendai, Miyagi, Japan, 980-0873

Actively Recruiting

178

Kansai Medical University Hospital

Hirakata, Osaka, Japan, 573-1191

Actively Recruiting

179

Kindai University Hospital

Sakai, Osaka, Japan, 590-0197

Actively Recruiting

180

Saitama Cancer Center

Kitaadachi-gun, Saitama, Japan, 362-0806

Actively Recruiting

181

Nippon Medical School - Nippon Medical School Hospital - Cancer Center

Bunkyo-ku, Tokyo, Japan, 113-8603

Actively Recruiting

182

Tottori University Hospital

Yonago, Tottori, Japan, 683-8504

Actively Recruiting

183

National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital)

Ube, Yamaguchi, Japan, 755-0241

Actively Recruiting

184

National Hospital Organization Kyushu Medical Center

Fukuoka, Japan, 810-8563

Actively Recruiting

185

Niigata Cancer Center Hospital

Niigata, Japan, 951-8566

Actively Recruiting

186

Osaka International Cancer Institute

Osaka, Japan, 541-8567

Actively Recruiting

187

Universiti Malaya Medical Centre

Kuala Lumpur, Kuala Lumpur, Malaysia, 59100

Actively Recruiting

188

University Hospital Kebangsaan Malaysia

Cheras, Kuala Lumpur and Selangor, Malaysia, 56000

Withdrawn

189

Gleneagles Penang Medical Center

George Town, Pulau Pinang, Malaysia, 10050

Actively Recruiting

190

Sunway Medical Centre Penang

Perai, Pulau Pinang, Malaysia, 13700

Actively Recruiting

191

Beacon Hospital

Petaling Jaya, Selangor, Malaysia, 46050

Actively Recruiting

192

Columbia Asia Hospital Bukit Rimau

Shah Alam, Selangor, Malaysia, 40460

Actively Recruiting

193

Sunway Medical Centre

Subang Jaya, Selangor, Malaysia, 47500

Actively Recruiting

194

Instituto Nacional de Cancerología

Mexico City, Mexico City, Mexico, 14080

Actively Recruiting

195

Oncare Viaducto Nápoles

Mexico City, Mexico, 3810

Actively Recruiting

196

Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia

Monterrey, Mexico, 64460

Actively Recruiting

197

Oncología Integral Satélite

Naucalpan, Mexico, 53100

Actively Recruiting

198

Clinica Integral Internacional de Oncologia S. de R.L. de C.V.

Puebla City, Mexico, 72530

Actively Recruiting

199

ONCARE Treatment Center

San Pedro Garza García, Mexico, 66220

Actively Recruiting

200

Radboud University Medical Center | Afdeling Interne Geneeskunde

Nijmegen, Gelderland, Netherlands, 6500 HB

Withdrawn

201

Nederlands Kanker Instituut

Amsterdam, North Holland, Netherlands, 1066 CX

Actively Recruiting

202

Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej

Warsaw, Masovian Voivodeship, Poland, 02-781

Not Yet Recruiting

203

Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej

Warsaw, Masovian Voivodeship, Poland, 02-781

Withdrawn

204

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, Poland, 15-276

Withdrawn

205

Swietokrzyskie Centrum Onkologii

Kielce, Poland, 25-734

Actively Recruiting

206

Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi

Lodz, Poland, 92-213

Completed

207

Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku

Otwock, Poland, 05-400

Completed

208

Wielkopolskie Centrum Pulmonologii i Torakochirurgii

Poznan, Poland, 60-569

Actively Recruiting

209

Instytut Gruzlicy i Chorob Pluc

Warsaw, Poland, 01-138

Withdrawn

210

Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii

Wroclaw, Poland, 53-413

Withdrawn

211

Hospital Pedro Hispano | Clinical Research Center

Matosinhos Municipality, Porto District, Portugal, 4464-513

Actively Recruiting

212

Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Urologia

Coimbra, Portugal, 3004-561

Actively Recruiting

213

Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica

Lisbon, Portugal, 1400-038

Actively Recruiting

214

CHULN - Hospital Pulido Valente

Lisbon, Portugal, 1769-001

Actively Recruiting

215

IPO Porto

Porto, Portugal, 4200-072

Actively Recruiting

216

Radiotherapy Center Cluj SRL

Flore?ti, Comuna Floresti, Romania, 407280

Actively Recruiting

217

Sc Oncolab Srl

Craiova, Dolj, Romania, 200385

Actively Recruiting

218

Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II

Bucharest, Romania, 22328

Actively Recruiting

219

Spitalul Clinic Coltea

Bucharest, Romania, 30171

Actively Recruiting

220

CardioMed S.R.L.

Cluj-Napoca, Romania, 400015

Actively Recruiting

221

Institutul Oncologic Prof. Dr. Ion Chiricuta

Cluj-Napoca, Romania, 400015

Actively Recruiting

222

Centrul de Oncologie Sfantul Nectarie

Craiova, Romania, 200745

Actively Recruiting

223

S.C Ovidius Clinical Hospital SRL - Oncology Department

Ovidiu, Romania, 905900

Actively Recruiting

224

Oncocenter

Timișoara, Romania, 300166

Actively Recruiting

225

National Cancer Center Singapore - Oncology Department

Singapore, Singapore, 168583

Not Yet Recruiting

226

Raffles Cancer Centre

Singapore, Singapore, 188770

Actively Recruiting

227

OncoCare Cancer Centre | Gleneagles Medical Centre

Singapore, Singapore, 258499

Actively Recruiting

228

Tan Tock Seng Hospital

Singapore, Singapore, 308433

Actively Recruiting

229

Curie Oncology | Farrer

Singapore, Singapore, 329563

Actively Recruiting

230

POKO Poprad s.r.o.

Poprad, Slovakia, 058 01

Actively Recruiting

231

Fakultna nemocnica Trnava

Trnava, Slovakia, 91775

Actively Recruiting

232

Gyeongsang National University Hospital

Jinju, Gyeongsangnam-do, South Korea, 52727

Actively Recruiting

233

Pusan National University Yangsan Hospital

Yangsan, Gyeongsangnam-do, South Korea, 50612

Actively Recruiting

234

Chonnam National University Hwasun Hospital | Pulmonology and Critical Care Medicine

Hwasun Gun, Jeollanam-do, South Korea, 58128

Actively Recruiting

235

Chungbuk National University Hospital

Cheongju-si, North Chungcheong, South Korea, 28644

Actively Recruiting

236

Severance Hospital, Yonsei University Health System - Oncology Department

Seoul, Seoul Teugbyeolsi, South Korea, 03722

Actively Recruiting

237

Seoul National University Hospital

Seoul, Seoul Teugbyeolsi, South Korea, 3080

Actively Recruiting

238

Samsung Medical Center - Oncology Department

Seoul, South Korea, 06351

Actively Recruiting

239

St.Vincent's Hospital - Oncology Department

Suwon, South Korea, 16247

Not Yet Recruiting

240

Hospital Germans Trias I Pujol | Oncologia

Badalona, Barcelona, Spain, 08916

Actively Recruiting

241

Hospital Universitario Puerta De Hierro De Majadahonda | Oncologia

Majadahonda, Madrid, Spain, 28222

Actively Recruiting

242

Hospital Universitario De Navarra | Oncologia

Pamplona, Navarre, Spain, 31008

Actively Recruiting

243

Complexo Hospitalario Universitario A Coruna | Oncologia

A Coruña, Spain, 15006

Actively Recruiting

244

Hospital Universitari Dexeus Grupo Quironsalud | Oncologia

Barcelona, Spain, 08028

Actively Recruiting

245

Hospital Universitari Vall D Hebron | Oncologia

Barcelona, Spain, 08035

Actively Recruiting

246

Hospital Clinic De Barcelona | Oncologia

Barcelona, Spain, 08036

Actively Recruiting

247

Hospital General Universitario Gregorio Maranon | Oncologia

Madrid, Spain, 28009

Actively Recruiting

248

Hospital Universitario Ramon Y Cajal | Oncologia

Madrid, Spain, 28034

Actively Recruiting

249

Hospital Universitario Fundacion Jimenez Diaz | Oncologia

Madrid, Spain, 28040

Actively Recruiting

250

Fundacion Instituto Valenciano De Oncologia | Oncologia

Valencia, Spain, 46009

Actively Recruiting

251

Hospital Universitario Y Politecnico La Fe | Oncologia

Valencia, Spain, 46026

Actively Recruiting

252

Skåne University Hospital

Lund, Skåne County, Sweden, 221 85

Actively Recruiting

253

Norrland University Hospital - Cancercentrum

Umeå, Västerbotten County, Sweden, 901 85

Actively Recruiting

254

Kantonsspital Baden

Baden, Canton of Aargau, Switzerland, 5404

Actively Recruiting

255

HFR Freiburg - Kantonsspital

Fribourg, Switzerland, 1708

Actively Recruiting

256

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan, 807377

Actively Recruiting

257

Chung Shan Medical University Hospital

Taichung, Taiwan, 402306

Actively Recruiting

258

Taichung Veterans General Hospital

Taichung, Taiwan, 40705

Actively Recruiting

259

National Cheng Kung University Hospital

Tainan, Taiwan, 704

Actively Recruiting

260

Chi-Mei Medical Center, Liouyine

Tainan, Taiwan, 73657

Actively Recruiting

261

National Taiwan University Hospital (NTUH) - Cancer Research Center

Taipei, Taiwan, 100225

Actively Recruiting

262

National Taiwan University Hospital

Taipei, Taiwan, 100

Actively Recruiting

263

Taipei Veterans General Hospital

Taipei, Taiwan, 11217

Actively Recruiting

264

Adana Sehir Egitim ve Arastirma Hastanesi

Yüreğir, Adana, Turkey (Türkiye), 1370

Actively Recruiting

265

Ankara Bilkent Sehir Hastanesi

Bilkent Ankara, Ankara, Turkey (Türkiye), 6800

Actively Recruiting

266

Ankara Etlik Sehir Hastanesi

Yenimahalle, Ankara, Turkey (Türkiye), 6170

Actively Recruiting

267

Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi

Kadıköy, Istanbul, Turkey (Türkiye), 34722

Actively Recruiting

268

I.A.Ü. VM Medical Park Florya Hastanesi

Küçükçekmece, Istanbul, Turkey (Türkiye), 34295

Actively Recruiting

269

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi

Istanbul, Turkey (Türkiye), 34899

Actively Recruiting

270

Ege Universitesi Tip Fakultesi Hastanesi

Izmir, Turkey (Türkiye), 35100

Actively Recruiting

271

Sakarya Universitesi Egitim ve Arastirma Hastanesi

Sakarya, Turkey (Türkiye), 54100

Actively Recruiting

272

LLC "RDP Ukraine" - Medical Department

Dnipro, Ukraine, 49102

Actively Recruiting

273

Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center

Kropyvnytskyi, Ukraine, 25006

Actively Recruiting

274

Kyiv City Clinical Oncology Center - Department of Chemotherapy #1

Kyiv, Ukraine, 03115

Actively Recruiting

275

Limited Liability Company "MedOffice Group Medical Center"

Kyiv, Ukraine, 03189

Actively Recruiting

276

Medical Center LLC "Verum Expert Clinic"

Kyiv, Ukraine, 3039

Actively Recruiting

277

Regional Medical Oncology Centre_Oncology Chemotherapy Department

Lutsk, Ukraine, 43018

Actively Recruiting

278

Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department

Rivne, Ukraine, 33010

Actively Recruiting

279

MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department

Uzhhorod, Ukraine, 88000

Actively Recruiting

280

Torbay Hospital

Torquay, Devon, United Kingdom, TQ2 7AA

Actively Recruiting

281

Belfast City Hospital

Belfast, Northern Ireland, United Kingdom, BT12 7AB

Withdrawn

282

Royal Surrey County Hospital

Guildford, Surrey, United Kingdom, GU2 7XX

Actively Recruiting

283

Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit

Cardiff, Wales, United Kingdom, CF14 2TL

Actively Recruiting

Loading map...

Research Team

B

Bayer Clinical Trials Contact

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) | DecenTrialz