Actively Recruiting
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
Led by Eli Lilly and Company · Updated on 2026-05-12
510
Participants Needed
194
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
CONDITIONS
Official Title
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician-diagnosed chronic rhinosinusitis with bilateral nasal polyps
- Prior treatment with systemic corticosteroids within the last 2 years or prior surgery for nasal polyps
- Endoscopic bilateral nasal polyp score of at least 5 out of 8, with minimum score of 2 in each nasal cavity at screening and baseline
- Ongoing symptoms for at least 8 weeks before study entry including nasal congestion with moderate or severe severity at screening and randomization
- At least one other symptom such as partial or total loss of smell, or anterior or posterior rhinorrhea
- If participant has asthma, it must be stable for at least 3 months with permitted regular treatment
- Adolescents aged 12 to less than 18 years must weigh at least 40 kg at first visit
You will not qualify if you...
- Prior use of lebrikizumab
- Use of rescue medication or need for surgery for nasal polyps during screening or run-in period
- Initiation of allergen immunotherapy within 6 months prior to screening unless on stable dose for at least 3 months
- Use of biologic treatments approved for nasal polyps, asthma, or atopic dermatitis within 4 months or 5 half-lives prior to screening
- Use of systemic immunosuppressants within 4 weeks prior to baseline
- Sinus intranasal surgery within 6 months prior to screening
- Prior sino-nasal or sinus surgery altering nasal structure making nasal polyp assessment difficult
- Conditions impacting endpoint assessment such as nasal septal deviation occluding nostril, antrochoanal polyps, acute sinusitis or nasal infection, ongoing rhinitis medicamentosa, other diagnoses associated with nasal polyps, nasal cavity tumors, or fungal rhinosinusitis
- Anosmia due to COVID or causes other than chronic rhinosinusitis with nasal polyps
- Forced expiratory volume in 1 second (FEV1) of 50% or less at screening
- Pregnant or breastfeeding females or planning pregnancy or breastfeeding during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 194 locations
1
AllerVie Clinical Research
Birmingham, Alabama, United States, 35209
Not Yet Recruiting
2
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
3
Keck Medicine of USC
Arcadia, California, United States, 91007
Not Yet Recruiting
4
University of California, Irvine
Irvine, California, United States, 92697
Actively Recruiting
5
DaVinci Research LLC
Roseville, California, United States, 95661
Actively Recruiting
6
Breathe Clear Institute
Torrance, California, United States, 90503
Actively Recruiting
7
Colorado ENT & Allergy
Colorado Springs, Colorado, United States, 80923
Actively Recruiting
8
Orlando ENT & Allergy
Orlando, Florida, United States, 32825
Not Yet Recruiting
9
NuLine Clinical Trial Center
Pompano Beach, Florida, United States, 33060
Not Yet Recruiting
10
University of South Florida
Tampa, Florida, United States, 33613
Actively Recruiting
11
Treasure Valley Medical Research
Boise, Idaho, United States, 83706
Actively Recruiting
12
Entopy Research LLC
Chicago, Illinois, United States, 60616
Actively Recruiting
13
Chicago ENT
Chicago, Illinois, United States, 60657
Actively Recruiting
14
South Louisiana Ear, Nose, Throat & Facial Plastic Surgery - PPDS
Mandeville, Louisiana, United States, 70471
Actively Recruiting
15
Chesapeake Clinical Research, Inc.
White Marsh, Maryland, United States, 21162
Actively Recruiting
16
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
17
University of Missouri
Columbia, Missouri, United States, 65212
Actively Recruiting
18
Washington University School of Medicine
St Louis, Missouri, United States, 63141
Not Yet Recruiting
19
Circuit Clinical/Mercer Allergy and Pulmonary Associates
Hamilton, New Jersey, United States, 08619
Not Yet Recruiting
20
Madison ENT & Facial Plastic Surgery
New York, New York, United States, 10016
Actively Recruiting
21
New York Allergy and Sinus Center
New York, New York, United States, 10016
Actively Recruiting
22
Equity Medical
The Bronx, New York, United States, 10455
Actively Recruiting
23
UCMC
Cincinnati, Ohio, United States, 45267
Not Yet Recruiting
24
Optimed Research, LTD
Columbus, Ohio, United States, 43235
Actively Recruiting
25
Medical University of South Carolina- Department of Otolaryngology and Head and Neck Surgery
Charleston, South Carolina, United States, 29425
Not Yet Recruiting
26
Alina Clinical Trials
Dallas, Texas, United States, 75209
Actively Recruiting
27
UT Southwestern Medical Center
Dallas, Texas, United States, 75390-9035
Not Yet Recruiting
28
University of Texas Physicians Department of Otorhinolaryngology Clinc
Houston, Texas, United States, 77030
Actively Recruiting
29
Ear Nose and Throat Associates of Texas PA
McKinney, Texas, United States, 75070-5735
Actively Recruiting
30
Alamo ENT Associates
San Antonio, Texas, United States, 78258-3227
Actively Recruiting
31
Eastern Virginia Medical School
Norfolk, Virginia, United States, 23507
Actively Recruiting
32
Richmond Ear Nose and Throat
Richmond, Virginia, United States, 23235
Not Yet Recruiting
33
The Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226-3548
Actively Recruiting
34
CEMLO - Centro de Especialidades Médicas Lobos
Beunos Aires, Argentina, B7240KJB
Actively Recruiting
35
Fundacion Respirar
Buenos Aires, Argentina, C1426BP
Actively Recruiting
36
Centro Platense en Investigaciones Respiratorias - CEPIR
Buenos Aires, Argentina
Actively Recruiting
37
Fundacion CIDEA
Caba, Argentina, C1121ABE
Not Yet Recruiting
38
Centro de Investigaciones Clínicas - IESR - Rosario
Rosario, Argentina, CP 2000
Actively Recruiting
39
Investigaciones en Patologías Respiratorias SRL
San Miguel de Tucumán, Argentina, CP4000
Actively Recruiting
40
CIMER-Centro Integral de Medicina Respiratoria
San Miguel de Tucumán, Argentina
Not Yet Recruiting
41
Centro Respiratorio Infantil
Santa Fe, Argentina, 2000
Not Yet Recruiting
42
CARE - Centro de Alergia y Enfermedades Respiratorias
Villa Crespo, Argentina, C1414AIF
Actively Recruiting
43
Pneumocare
Erpent, Belgium, 5101
Actively Recruiting
44
UZ Gent
Ghent, Belgium, 9000
Actively Recruiting
45
Cliniques Universitaires Saint-Luc Avenue Hippocrate 10
Woluwe-Saint-Lambert, Belgium, 1200
Actively Recruiting
46
Multiprofile Hospital For Active Treatment Dr Tota Venkova A
Gabrovo, Bulgaria, 1431
Actively Recruiting
47
Medical Center Medconsult Pleven OOD
Pleven, Bulgaria, 5800
Actively Recruiting
48
Diagnostic-Consultative Centre Ascendent EOOD
Sofia, Bulgaria, 1202
Actively Recruiting
49
Military Medical Academy - Multiprofile Hospital for Active Treatment - Sofia,
Sofia, Bulgaria, 1431
Not Yet Recruiting
50
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna
Sofia, Bulgaria, 1527
Actively Recruiting
51
Multiprofile Hospital for Active treatment Trakia EOOD
Zagora, Bulgaria, 1504
Not Yet Recruiting
52
St. Joseph's Hospital
Ontario, Canada, N6A 4V2
Actively Recruiting
53
CSAC
Québec, Canada
Actively Recruiting
54
The Gordon and Leslie Diamond Health Care Centre
Vancouver, Canada, V5Z 1M9
Not Yet Recruiting
55
St Paul's Sinus Centre
Vancouver, Canada, V6Z 1Y6
Not Yet Recruiting
56
Peking University Third Hospital
Beijing, China, 100191
Actively Recruiting
57
Beijing Hospital
Beijing, China, 100730
Not Yet Recruiting
58
Beijing Tongren Hospital
Beijing, China, 100730
Actively Recruiting
59
The First Affiliated Hospital of Bengbu Medical College
Bengbu, China, 233004
Not Yet Recruiting
60
The Third Xiangya Hospital of Central South University
Changsha, China, 410013
Actively Recruiting
61
Sichuan Provincial People's Hospital
Chengdu, China, 610072
Actively Recruiting
62
The First People's Hospital of Foshan
Foshan, China, 528000
Actively Recruiting
63
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, China, 350000
Actively Recruiting
64
Shenzhen Second People's Hospital
Guangdong, China
Actively Recruiting
65
Hainan General Hospital
Haikou, China, 570311
Not Yet Recruiting
66
Hangzhou First People's Hospital
Hangzhou, China
Actively Recruiting
67
Huai'an First People's Hospital
Huai'an, China, 223300
Actively Recruiting
68
The First Affiliated Hospital of Nanchang University
Nanchang, China, 330006
Actively Recruiting
69
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China, 530021
Actively Recruiting
70
Ningbo Medical Center Lihuili Hospital
Ningbo, China
Not Yet Recruiting
71
The first Affilliated Hospital Shandong First Medical University
Shandong, China, 250014
Actively Recruiting
72
Tongji Hospital of Tongji University
Shanghai, China
Actively Recruiting
73
Shengjing Hospital of China Medical University
Shenyang, China, 110004
Actively Recruiting
74
The First Hospital of Shanxi Medical University
Taiyuan, China, 30001
Actively Recruiting
75
Tianjin People's Hospital
Tianjin, China, 300121
Actively Recruiting
76
Tonghua Central Hospital
Tonghua, China, 134001
Not Yet Recruiting
77
The 2nd Affiliated Hospital of Wenzhou Medical University
Wenzhou Avenue, China, 325038
Actively Recruiting
78
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China, 430022
Actively Recruiting
79
Renmin Hospital of Wuhan University
Wuhan, China, 430060
Actively Recruiting
80
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China, 221006
Actively Recruiting
81
First People's Hospital of Yinchuan
Yinchuan, China, 750002
Actively Recruiting
82
Aalborg Universitetshospital Medicinerhuset Lungemedicinsk Forskningsenhed
Aalborg, Denmark
Actively Recruiting
83
Aarhus University Hospital, Dept. of Ear-Nose-Throat
Aarhus, Denmark, 8200
Actively Recruiting
84
Bispebjerg Hospital Department of Respiratory Medicine
Copenhagen, Denmark
Not Yet Recruiting
85
Sjællands Universitets Hospital
Køge, Denmark
Actively Recruiting
86
Department otorhinolaryngology - Head and Neck Surgery, Helsinki Univerity Hospital
Helsinki, Finland, 00130
Not Yet Recruiting
87
Departmentof Allergy, Skin and Allergy Hospital, Helsinki Univerity Hospital
Helsinki, Finland, 00250
Not Yet Recruiting
88
Charite-Universitatsmedizin Berlin
Berlin, Germany, 10117
Actively Recruiting
89
HNO Zentrum am Kudamm
Berlin, Germany, 10629
Actively Recruiting
90
Praxis für HNO und Allergologie
Dresden, Germany, 01139
Actively Recruiting
91
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany, 74, 01307
Actively Recruiting
92
IKF Pneumologie
Frankfurt am Main, Germany, 60596
Actively Recruiting
93
Universitätsklinikum Jena
Jena, Germany, 07747
Not Yet Recruiting
94
Universitätsklinikum Schleswig-Holstein
Lübeck, Germany, 23538
Not Yet Recruiting
95
HNO Praxis
Sachsen, Germany, 01067
Actively Recruiting
96
Ujpesti Egeszsegugyi Szolgaltato
Budapest, Hungary, 1046
Actively Recruiting
97
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
Tatabánya, Hungary, H-2800
Actively Recruiting
98
AOU Careggi- University of Florence
Florence, Italy, 50134
Not Yet Recruiting
99
Ospedale San Raffaele
Milan, Italy, 20132
Not Yet Recruiting
100
AOU Federico II Via Pansini
Naples, Italy, 80131
Actively Recruiting
101
Azienda Ospedaliera Di Padova
Padova, Italy, 35128
Actively Recruiting
102
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara
Pisa, Italy, 56126
Actively Recruiting
103
Fondazione Policlinico A. Gemelli IRCCS
Rome, Italy, 800168
Actively Recruiting
104
ASST Brianza - Vimercate Hospital
Vimercate, Italy, 20871
Actively Recruiting
105
Toyota Memorial Hospital
Aichi, Japan
Actively Recruiting
106
Clinic Kashiwanoha
Chiba, Japan
Actively Recruiting
107
University of Yamanashi Hospital
Chūō, Japan, 409-3821
Actively Recruiting
108
University of Fukui Hospital
Fukui, Japan
Actively Recruiting
109
Saiseikai Fukuoka General Hospital
Fukuoak, Japan, 810-0001
Actively Recruiting
110
Matsuda Hospital
Fukuoka, Japan, 812-0053
Actively Recruiting
111
Kyushu University Hospital
Fukuoka, Japan, 812-8582
Actively Recruiting
112
Osaka Habikino Medical Center
Habikino-shi, Japan, 583-8588
Actively Recruiting
113
Kansai Medical University Hospital
Hirakata, Japan, 573-1191
Actively Recruiting
114
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
Hokkaido, Japan, 060-0033
Actively Recruiting
115
Hyogo Medical University Hospital
Hyōgo, Japan, 663-8131
Actively Recruiting
116
Takarazuka City Hospital
Hyōgo, Japan, 665-0827
Actively Recruiting
117
Ibaraki Prefectural Central Hospital
Ibaraki, Japan
Actively Recruiting
118
Kagoshima Kouseiren Hospital
Kagoshima, Japan, 890-0062
Actively Recruiting
119
Yokohama City Minato Red Cross Hospital
Kanagawa, Japan, 231-0801
Actively Recruiting
120
Odawara Municipal Hospital
Kanagawa, Japan, 250-8558
Actively Recruiting
121
Tokai University Hospital
Kanagawa, Japan, 259-1193
Actively Recruiting
122
Kimitsu Chuo Hospital
Kisarazu, Japan, 292-8535
Actively Recruiting
123
1-8-1, Kishinoura
Kitakyushu, Japan, 806-8501
Actively Recruiting
124
3-54-2, Kotohirahommachi
Kumamoto, Japan, 860-0814
Actively Recruiting
125
Kyosai Hospital
Minami-Alps, Japan, 400-0405
Actively Recruiting
126
Tohoku Medical and Pharmaceutical University Hospital
Miyagi, Japan
Actively Recruiting
127
Ritsuzankai Iida Hospital
Nagano, Japan, 395-0056
Actively Recruiting
128
Asahioka, 1-24
Niigata, Japan, 940-8621
Actively Recruiting
129
Niigata University Medical & Dental Hospital
Niigata, Japan, 951-8520
Actively Recruiting
130
Japan Community Health care Organization Osaka Hospital
Osaka, Japan, 553-0003
Actively Recruiting
131
Kansai Electric Power Hospital
Osaka, Japan, 553-0003
Actively Recruiting
132
Toho University Sakura Medical Center
Sakura, Japan, 285-0841
Actively Recruiting
133
8-2 Otemachi
Shizuoka, Japan, 420-0853
Actively Recruiting
134
Toho University Ohashi Medical Center
Tokyo, Japan, 153-8515
Actively Recruiting
135
Nihon University Itabashi Hospital
Tokyo, Japan, 173-0032
Actively Recruiting
136
Mie University Hospital
Tsu, Japan, 514-8507
Actively Recruiting
137
JCHO Shimonoseki Medical center
Yamaguchi, Japan, 750-0061
Actively Recruiting
138
Yamaguchi University Hospital
Yamaguchi, Japan, 755-8505
Not Yet Recruiting
139
Yokohama Minami Kyosai Hospital
Yokohama, Japan, 236-0037
Actively Recruiting
140
Avenida Independencia
Aguascalientes, Mexico, 20116
Not Yet Recruiting
141
Calle Pascual Orozco #2125 col. Magisterial Universidad
Chihuahua City, Mexico, CP 31200
Not Yet Recruiting
142
Calle Penitenciaria
Guadalajara Jalsico, Mexico, 44100
Not Yet Recruiting
143
Miguel Hidalgo 2525, Consultorio 2 Urgencias
Nuevo León, Mexico, 64060
Not Yet Recruiting
144
Humboldt 302 Col. Centro
Oaxaca City, Mexico, 68000
Not Yet Recruiting
145
Niepubliczny Zakład Opieki Zdrowotnej E-Vita
Bialystok, Poland, 15-879
Actively Recruiting
146
Centrum Medyczne Pratia Katowice
Katowice, Poland, 40-081
Actively Recruiting
147
Centrum Medyczne Angelius Provita
Katowice, Poland, 40-611
Actively Recruiting
148
B&R Clinical Sp. z o.o
Kielce, Poland, 25-426
Actively Recruiting
149
Centrum Medyczne All-Med
Krakow, Poland, 30-033
Actively Recruiting
150
Centrum Medyczne Promed ul. Olszańska 5G
Krakow, Poland, 31-513
Actively Recruiting
151
Specjalistyczny Niepubliczny Zakład Opieki Zdrowotnej Alergologia Plus Ośrodek Diagnostyki
Poznan, Poland, 60-693
Actively Recruiting
152
WIM-PIB
Warsaw, Poland
Actively Recruiting
153
Centrum Medyczne Biotamed Morawska Barbara
Wieliczka, Poland, 32-020
Actively Recruiting
154
EMC INSTYTUT MEDYCZNY S.A. Przychodnia
Wroclaw, Poland, 50-220
Actively Recruiting
155
Centrum Medyczne Oporów
Wroclaw, Poland, 52-416
Actively Recruiting
156
Unidade Local de Saúde de Almada-Seixal, E.P.E.
Almada, Portugal
Not Yet Recruiting
157
ULS da Região de Aveiro, EPE - Hospital Infante D. Pedro
Aveiro, Portugal, 3814-501
Actively Recruiting
158
Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga)
Braga, Portugal, 4710-243
Not Yet Recruiting
159
Unidade Local de Saúde Loures-Odivelas
Loures, Portugal
Actively Recruiting
160
ULS do Algarve, EPE - Hospital de Portimão
Seco Portimao Faro, Portugal, 8500-338
Actively Recruiting
161
Hospital Pedro Hispano
Senhora da Hora, Portugal, 4464-513
Actively Recruiting
162
Centrul Medical Unirea SRL
Brasov, Romania, 500091
Actively Recruiting
163
Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L
Brasov, Romania, 500450
Actively Recruiting
164
Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L
Brasov, Romania, 500450
Actively Recruiting
165
Delta Health Care S.R.L
Bucharest, Romania, 14142
Actively Recruiting
166
Delta Health Care S.R.L
Bucharest, Romania, 14142
Actively Recruiting
167
Cardiomed S.R.L
Cluj-Napoca, Romania, 400015
Actively Recruiting
168
Centrul de Excelenta in Rinologie S.R.L
Dolj, Romania, 200222
Actively Recruiting
169
Inje University Haeundae Paik Hospital
Busan, South Korea, 48108
Actively Recruiting
170
CHA Bundang Medical Center
Gyeonggi-do, South Korea, 13496
Actively Recruiting
171
Pusan National University Hospital
Pusan, South Korea, 49241
Actively Recruiting
172
Seoul National University Bundang Hospital
Seongnam-si, South Korea, 13620
Actively Recruiting
173
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
174
SNUH - Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
175
The Catholic University of Korea
Seoul, South Korea, 06591
Actively Recruiting
176
Korea University Guro Hospital
Seoul, South Korea, 08308
Not Yet Recruiting
177
SMG-SNU Boramae Medical Center
Seoul, South Korea, 7061
Actively Recruiting
178
Ajou University Hospital
Suwon, South Korea, 16499
Actively Recruiting
179
Hospital Universitario Virgen de la Macarena Avenida Dr. Fedriani
Andalucia, Spain, 41009
Actively Recruiting
180
Centro Médico Teknon
Barcelona, Spain, 8022
Actively Recruiting
181
Hospital Universitario de Jerez
Cadiz, Spain, 11407
Actively Recruiting
182
Hospital Clínico Universitario de Santiago
Galícia, Spain, 15706
Not Yet Recruiting
183
FutureMeds DKF
Madrid, Spain, 28002
Actively Recruiting
184
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain, 28040
Actively Recruiting
185
Clinica Universidad de Navarra
Pamplona, Spain, 31008
Actively Recruiting
186
Taipei Medical University Shuang Ho Hospital
New Taipei City, Taiwan, 23561
Actively Recruiting
187
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
188
Bristol Royal Infirmary University Hospitals
Bristol, United Kingdom, BS2 8HW
Actively Recruiting
189
Charing Cross Hospital
Chelsea, United Kingdom, W6 8RF
Not Yet Recruiting
190
James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, United Kingdom, NR31 6LA
Actively Recruiting
191
Royal Berkshire NHS Foundation Trust
London, United Kingdom, RG1 5AN
Actively Recruiting
192
Guys and St Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
Actively Recruiting
193
Newcastle upon Tyne Hospitals NHSFT Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
194
Stepping Hill Hospital
Stockport, United Kingdom, SK2 7JE
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here