Actively Recruiting
Study of Letrozole in Recurrent Gliomas
Led by University of Cincinnati · Updated on 2026-04-16
39
Participants Needed
1
Research Sites
550 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.
CONDITIONS
Official Title
Study of Letrozole in Recurrent Gliomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Radiographically, histologically, or cytologically confirmed recurrent high grade brain glioma with plan for resection or biopsy
- Age over 18 years
- ECOG performance status 0 to 2 (Karnofsky score over 60%)
- Adequate bone marrow function: ANC ≥ 1,000 cells/mm3, platelets ≥ 100,000 cells/mm3, hemoglobin ≥ 8.0 g/dl
- Adequate liver function: total bilirubin less than 2 times institutional upper limit, AST or ALT less than 3 times institutional upper limit
- Adequate kidney function: GFR over 30 ml/min or creatinine less than 1.5
- Negative pregnancy test within 2 weeks before registration for women who can become pregnant
- Brain MRI imaging prior to treatment (contrast preferred but not required)
- Ability to understand and sign informed consent
- Measurable disease per RANO criteria within 28 days before treatment start (sub-study only)
You will not qualify if you...
- Receiving other investigational agents
- History of allergic reaction to letrozole or temozolomide (sub-study only)
- Uncontrolled serious illness including recent heart failure exacerbation, unstable angina, recent myocardial infarction within 6 months
- Active infections such as AIDS or hepatitis B or C
- Psychiatric or medical conditions limiting ability to participate
- Pregnant or nursing women
- Patients attempting to conceive
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Actively Recruiting
Research Team
U
UC Cancer Center Clinical Trials Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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