Investigating Changes in Liver Cell Membranes Related to Metabolic Steatohepatitis in Adults Having Bariatric Surgery

What this Trial Is About

Researchers are investigating the link between Metabolic Dysfunction-Associated Steatohepatitis MASH and changes in mitochondria-associated membranes MAMs in liver cells and blood cells of patients with Metabolic Dysfunction-Associated Steatotic Liver Disease MASLD. The study focuses on understanding how these MAM alterations may play a role in the progression and improvement of MASH. This research is conducted in patients undergoing bariatric surgery and aims to provide insights into liver cell changes related to this condition. Participants are patients with MASLD who are undergoing bariatric surgery, such as sleeve gastrectomy or gastric bypass, and have an indication for liver biopsy due to suspected MASH. During surgery, liver biopsies will be taken to analyze MAM alterations in liver cells and peripheral blood mononuclear cells PBMCs. Follow-up assessments will be conducted at 6 and 12 months after surgery to monitor changes in MAMs and liver disease markers. Throughout the study, participants will undergo liver biopsies during surgery and blood sample collection at baseline, 6 months, and 12 months. Researchers will examine MAM alterations in different liver cell types and blood cells, and assess the correlation between MAM changes and liver disease improvement. The study will measure changes in liver disease markers over time and track participants progress up to one year after surgery. The total participation duration includes the surgery and follow-up visits over 12 months.

Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA