Actively Recruiting
Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
Led by Virginia Polytechnic Institute and State University · Updated on 2025-06-06
80
Participants Needed
1
Research Sites
290 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and heat evoked brain signaling using a quantitative sensory testing device. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.
CONDITIONS
Official Title
Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers who understand and speak English
- Adults aged 18 to 65 years
- All ethnicities
You will not qualify if you...
- Claustrophobia that could make scanning uncomfortable
- Contraindications to MRI such as pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants
- Contraindications to CT, including pregnancy
- Active medical disorders or treatments affecting the central nervous system (e.g., Alzheimer's disease)
- History of neurological disorders such as Parkinson's disease, epilepsy, or essential tremor
- History of head injury with loss of consciousness lasting more than 10 minutes
- History of alcohol or drug dependence
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fralin Biomedical Research Institute
Roanoke, Virginia, United States, 24016
Actively Recruiting
Research Team
J
Jessica W Florig, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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