Actively Recruiting
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Led by Eli Lilly and Company · Updated on 2026-03-02
279
Participants Needed
36
Research Sites
393 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.
CONDITIONS
Official Title
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently enrolled and active in the originator study LOXO-BTK-18001
- Active participants include those receiving study intervention, in short-term follow-up, or in long-term follow-up
You will not qualify if you...
- Previously participated in the Phase 1b cohort of Study LOXO-BTK-18001
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 36 locations
1
Sylvester Comprehensive Cancer Center
Miami, Florida, United States, 33136-1002
Actively Recruiting
2
Florida Cancer Specialists
Sarasota, Florida, United States, 34232-6422
Actively Recruiting
3
The Emory Clinic
Atlanta, Georgia, United States, 30322-1013
Actively Recruiting
4
Northwestern University
Chicago, Illinois, United States, 60611-3013
Actively Recruiting
5
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Actively Recruiting
6
Mayo Clinic- Minnesota
Rochester, Minnesota, United States, 55905
Actively Recruiting
7
University Of Nebraska Medical Center
Omaha, Nebraska, United States, 69198
Actively Recruiting
8
Cayuga Cancer Center
Ithaca, New York, United States, 14850
Active, Not Recruiting
9
Northwell Health
Lake Success, New York, United States, 11042-1118
Actively Recruiting
10
Memorial Sloan-Kettering Cancer Center (MSKCC) - New York
New York, New York, United States, 10065-6007
Actively Recruiting
11
Memorial Sloan-Kettering Cancer Center (MSKCC) - New York
New York, New York, United States, 10065-6007
Active, Not Recruiting
12
Duke University Medical Center
Durham, North Carolina, United States, 27710-4000
Actively Recruiting
13
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210-1063
Actively Recruiting
14
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
15
Tennessee Oncology
Nashville, Tennessee, United States, 37203-2659
Actively Recruiting
16
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030-4000
Actively Recruiting
17
Swedish Cancer Institute
Seattle, Washington, United States, 98104-3588
Actively Recruiting
18
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226-3548
Actively Recruiting
19
Flinders Medical Centre
Adelaide, Australia, 5042
Actively Recruiting
20
Peter MacCallum Cancer Centre
Melbourne, Australia, 3000
Completed
21
Linear Clinical Research
Victoria, Australia, 3000
Active, Not Recruiting
22
CHU de Nantes - Hotel Dieu
Nantes, France, 44093
Actively Recruiting
23
IRCCS-AOU di Bologna-Policlinico S.Orsola-Malpighi
Bologna, Italy, 40138
Completed
24
Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
25
Nagoya Medical Center
Aichi-Ken, Japan, 4600001
Active, Not Recruiting
26
National Cancer Center Hospital
Cho-ku, Japan, 104-0045
Completed
27
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan, 811-1395
Active, Not Recruiting
28
Tokai University Hospital- Isehara Campus
Isehara, Japan, 259-1193
Active, Not Recruiting
29
Tohoku University Hospital
Miyagi-Ken, Japan, 9808574
Active, Not Recruiting
30
Hokkaido University Hospital
Sapporo, Japan, 060-8648
Active, Not Recruiting
31
Pratia MCM Krakow
Krakow, Poland, 30727
Actively Recruiting
32
Instytut Hermatologii I Transfuzjologii
Warsaw, Poland, 02-776
Actively Recruiting
33
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
34
St James's University Hospital
Leeds, United Kingdom, LS9 7TF
Actively Recruiting
35
Churchill Hospital
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
36
Derriford Hospital
Plymouth, United Kingdom, PL6 8DH
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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