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Phase 2 Study of LY4005130 Given Intravenously to Adults With Non-Segmental Vitiligo to Evaluate Safety and Effectiveness
Led by Eli Lilly and Company · Updated on 2026-08-06
66
Participants Needed
35
Research Sites
17 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and side effects of LY4005130, a drug given through a vein, in adults with non-segmental vitiligo NSV. This study compares LY4005130 to a placebo to better understand how well the drug is tolerated. The trial is a Phase 2, randomized, double-blind study lasting about 48 weeks, including screening, to provide detailed information on treatment effects. Participants receive either LY4005130 or a placebo intravenously during the 24-week treatment period. Blood tests will be used to see how the drug moves through and affects the body. The study measures changes in vitiligo skin area using scoring indexes and also examines gene expression from skin biopsies. The comparison between the drug and placebo aims to provide clear insights into treatment effects. Throughout the study, participants will have assessments including blood tests and skin biopsies at the start and after treatment. Researchers will track side effects and changes in vitiligo by measuring the affected skin area. The study includes regular evaluations of drug levels in the blood and gene activity related to vitiligo. Participation involves about 48 weeks total, covering screening, treatment, and follow-up to monitor safety and response.
CONDITIONS
Brief Title
A Study of LY4005130 in Adult Participants With Non-Segmental Vitiligo
Research Team
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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
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Physicians interested in becoming principal investigators please contact
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