Actively Recruiting
A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
Led by Eli Lilly and Company · Updated on 2026-05-14
60
Participants Needed
30
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate how well LY4005130 works in participants with severe alopecia areata (hair loss) when compared with placebo, and how well it's tolerated and what side effects may occur. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study drug will be administered intravenously (IV) (into a vein in the arm). The study will last approximately 48 weeks, including screening.
CONDITIONS
Official Title
A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have severe alopecia areata with hair loss covering 50% to 90% of the scalp measured by the Severity of Alopecia Tool (SALT) score
- Current episode of severe alopecia areata lasting at least 6 months and no more than 4 years
- No significant spontaneous hair regrowth for at least 6 months
- Agree not to use any alopecia areata treatments during the study
- Age between 18 and 50 years
You will not qualify if you...
- Have primarily "diffuse" type alopecia areata characterized by diffuse hair shedding
- Currently have other forms of alopecia
- Have unstable concomitant diseases requiring frequent hospitalizations or systemic immunosuppressants
- Have used oral JAK inhibitors in the past
- Have had major surgery within 8 weeks before screening or will require major surgery during the study
- Have a history or presence of serious and/or unstable cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, hematological, neurological, or neuropsychiatric disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 30 locations
1
Center For Dermatology Clinical Research, Inc.
Fremont, California, United States, 94538
Not Yet Recruiting
2
Northridge Clinical Trials
Northridge, California, United States, 91325
Actively Recruiting
3
Cura Clinical Research - Santa Clarita - Kelly Johnson Parkway
Santa Clarita, California, United States, 91355
Not Yet Recruiting
4
Health Clinical Research, LLC
Miami, Florida, United States, 33176
Actively Recruiting
5
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
6
Revival Research Institute, LLC
Troy, Michigan, United States, 48084
Actively Recruiting
7
Stracskin
Portsmouth, New Hampshire, United States, 03801
Actively Recruiting
8
Texas Dermatology and Laser Specialists - San Antonio - South New Braunfels Avenue
San Antonio, Texas, United States, 78235
Not Yet Recruiting
9
Jordan Valley Dermatology & Research Center
South Jordan, Utah, United States, 84095
Actively Recruiting
10
Kelowna Health and Memory Centre
Kelowna, Canada, V1Y 5A8
Not Yet Recruiting
11
Ryan Clinical Research Inc.
Newmarket, Canada, L3Y 5G8
Not Yet Recruiting
12
Dar Clinical Research - Ottawa - Hunt Club Road
Ottawa, Canada, K1V 1C1
Not Yet Recruiting
13
SIMa Recherche
Verdun, Canada, H4G 2L8
Not Yet Recruiting
14
Beijing Friendship Hospital Affiliate of Capital University
Beijing, China, 100050
Not Yet Recruiting
15
Huashan Hospital, Fudan University
Shanghai, China, 200040
Not Yet Recruiting
16
Shanghai Skin Disease Hospital
Shanghai, China, 200071
Not Yet Recruiting
17
Tianjin Medical University General Hospital
Tianjin, China, 300052
Not Yet Recruiting
18
Erasmus Medisch Centrum
Rotterdam, Netherlands, 3015 GD
Not Yet Recruiting
19
Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, Poland, 80-546
Not Yet Recruiting
20
Diamond Clinic
Krakow, Poland, 31-559
Not Yet Recruiting
21
Dermedic Jacek Zdybski
Ostrowiec Świętokrzyski, Poland, 27-400
Not Yet Recruiting
22
Centrum Medyczne Ginemedica
Wroclaw, Poland, 50-414
Not Yet Recruiting
23
Chung-Ang University Hospital
Dongjak-gu, South Korea, 06973
Not Yet Recruiting
24
Inha University Hospital
Incheon, South Korea, 22332
Not Yet Recruiting
25
Jeonbuk National University Hospital
Jeonju, South Korea, 54907
Not Yet Recruiting
26
Seoul National University Hospital
Seoul, South Korea, 03080
Not Yet Recruiting
27
Kyung Hee University Hospital at Gangdong
Seoul, South Korea, 05278
Not Yet Recruiting
28
Royal London Hospital
London, United Kingdom, E1 1FR
Not Yet Recruiting
29
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom, SW10 9NH
Not Yet Recruiting
30
Salford Royal Hospital
Salford, United Kingdom, M6 8HD
Not Yet Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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