Actively Recruiting
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
Led by Eli Lilly and Company · Updated on 2026-05-12
216
Participants Needed
5
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body. Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 10 visits. Participation in Part E will last approximately 7 weeks and may include up to 12 visits.
CONDITIONS
Official Title
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- No significant body weight change in the 3 months before screening
- For Parts A and E: Healthy with a BMI of 22 to 35 kg/m2 at screening
- For Part B: BMI of 27 to 45 kg/m2 at screening
- For Part C: BMI of 25 to 45 kg/m2 at screening
- For Part D: Type 2 diabetes with hemoglobin A1C between 6.5% and 10.5% and BMI of 27 to 45 kg/m2 at screening
You will not qualify if you...
- Acute cardiovascular condition within 6 months before screening
- Liver disease or pancreatitis
- Use of weight loss medications within 3 months before screening
- For Parts A, B, C, and E: Any form of diabetes
- For Part D: Type 1 diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States, 32117
Completed
2
Clinical Pharmacology of Miami
Miami, Florida, United States, 33172
Actively Recruiting
3
Fortrea Clinical Research Unit
Dallas, Texas, United States, 75247
Completed
4
Endeavor Clinical Trials
San Antonio, Texas, United States, 78240
Active, Not Recruiting
5
Lilly Centre for Clinical Pharmacology
Singapore, Singapore, 138623
Completed
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
11
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