Actively Recruiting
A Study of LY4175408 in Participants With Advanced Cancer
Led by Eli Lilly and Company · Updated on 2026-04-17
240
Participants Needed
25
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to measure the safety and efficacy of LY4175408 in participants with selected advanced cancer. In addition, this study will evaluate how much LY4175408 gets into the bloodstream, how it is broken down, and how long it takes the body to get rid of it. Participation could last up to 4 years.
CONDITIONS
Official Title
A Study of LY4175408 in Participants With Advanced Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have one of the following advanced or metastatic solid tumors: non-small cell lung cancer, small cell lung cancer, endometrial cancer, or triple negative breast cancer
- Have received all standard therapies for which you were suitable, or are refusing remaining appropriate standard treatment, or no standard therapy is available
- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 1 or less
- For dose optimization and expansion cohorts, have measurable disease per RECIST v1.1 criteria
You will not qualify if you...
- Prior treatment with a protein tyrosine kinase 7 antibody-drug conjugate with a topoisomerase I inhibitor payload
- Any serious unresolved side effects from prior treatments
- Known or suspected uncontrolled central nervous system metastases
- Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection
- Significant cardiovascular disease
- Prolonged QT interval corrected for heart rate (QTcF) greater than 470 milliseconds
- History of pneumonitis or interstitial lung disease
- Pregnant, breastfeeding, or planning to breastfeed during the trial or within 30 days after last dose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Stanford Cancer Center
Stanford, California, United States, 94305
Actively Recruiting
2
Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute
Orlando, Florida, United States, 32827
Actively Recruiting
3
Florida Cancer Specialists - Sarasota
Sarasota, Florida, United States, 34236
Actively Recruiting
4
The University of Chicago Medical Center (UCMC)
Chicago, Illinois, United States, 60637
Actively Recruiting
5
Community Health Network
Indianapolis, Indiana, United States, 46250
Not Yet Recruiting
6
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
7
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
8
John Theurer Cancer Center At Hackensack UMC
Hackensack, New Jersey, United States, 07601
Actively Recruiting
9
Columbia University
New York, New York, United States, 10032
Actively Recruiting
10
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
11
The Ohio State University (OSU) Wexner Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
12
Sarah Cannon Research Institute
Nashville, Tennessee, United States, 37203
Actively Recruiting
13
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
14
START Mountain Region
West Valley City, Utah, United States, 84119
Actively Recruiting
15
NEXT Virginia
Fairfax, Virginia, United States, 22031
Actively Recruiting
16
Shanghai East Hospital, Tongji University
Shanghai, China, 0200120
Not Yet Recruiting
17
Centre Leon Berard
Lyon, France, 69373
Actively Recruiting
18
Institut Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
19
Kyoto University Hospital
Kyoto, Japan, 606-8507
Actively Recruiting
20
National Cancer Center Hospital
Tokyo, Japan, 104-0045
Actively Recruiting
21
Cancer Institute Hospital of JFCR
Tokyo, Japan, 135-8550
Actively Recruiting
22
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
23
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
24
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
25
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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