Actively Recruiting
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
Led by Eli Lilly and Company · Updated on 2026-05-04
141
Participants Needed
9
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate how well LY4213663 is tolerated and what side effects may occur in healthy participants and participants with rheumatoid arthritis (RA). The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last approximately 33 weeks excluding screening.
CONDITIONS
Official Title
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a body mass index (BMI) of 18.0 to 32.0 kilogram per square meter (kg/m²), inclusive
- For Parts C and D only: body weight at least 50 kilograms and BMI within 18.0 to 40.0 kg/m² at screening
- For Parts C and D only: diagnosis of adult-onset rheumatoid arthritis for at least 3 months before screening
You will not qualify if you...
- For healthy participants in Parts A and B only: history or presence of cardiovascular, respiratory, liver, eye, kidney, digestive, hormone, blood, neurological, or psychiatric disorders that could affect drug absorption, metabolism, or elimination
- For participants with rheumatoid arthritis in Parts C and D only: Class 4 rheumatoid arthritis according to ACR criteria
- For participants with rheumatoid arthritis in Parts C and D only: abnormal 12-lead electrocardiogram (ECG) at screening
- For participants with rheumatoid arthritis in Parts C and D only: current or recent acute active infection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 9 locations
1
Pinnacle Research Group, LLC
Anniston, Alabama, United States, 36207
Actively Recruiting
2
Arizona Research Center
Phoenix, Arizona, United States, 85053
Actively Recruiting
3
Clinical Research of West Florida, Inc. (Clearwater)
Clearwater, Florida, United States, 33765
Not Yet Recruiting
4
GNP Research at Mark Jaffe, MD
Cooper City, Florida, United States, 33024
Actively Recruiting
5
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States, 32117
Actively Recruiting
6
AGA Clinical Trials
Hialeah, Florida, United States, 33012
Actively Recruiting
7
Advanced Pharma CR, LLC
Miami, Florida, United States, 33417
Actively Recruiting
8
Floridian Clinical Research
Miami Lakes, Florida, United States, 33016
Actively Recruiting
9
Oasis Clinical Research
Las Vegas, Nevada, United States, 89121
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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