Actively Recruiting
A Study of LY4515100 in Participants With Pain Following Third Molar Removal
Led by Eli Lilly and Company · Updated on 2026-05-01
212
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety and efficacy of LY4515100 and see how a single oral dose compares with placebo in acute postsurgical pain after removing impacted third molars. For each participant, the study may last approximately 6 weeks and will include a stay in a Clinical Research Unit (CRU) after third molar removal.
CONDITIONS
Official Title
A Study of LY4515100 in Participants With Pain Following Third Molar Removal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) between 18.5 and 35.0 kg/m² inclusive
- Requires extraction of 2 or more third molars, including 2 mandibular molars with partial or full bony impaction confirmed by panoramic X-ray
You will not qualify if you...
- Dental surgery within 60 days before screening or other surgeries that could affect postoperative procedures
- Chronic pain conditions that could affect postsurgical pain reporting
- Positive urine drug screen or alcohol test at screening or on surgery day
- Significant hematological, renal, hepatic, endocrine, pulmonary, gastrointestinal, cardiovascular, psychiatric, or neurologic diseases within the last 5 years
- History of malignancy within 5 years prior to consent except treated and cured in situ carcinoma of the cervix or localized basal or squamous skin carcinoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
JBR Clinical Research
Salt Lake City, Utah, United States, 84107
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here