Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT07226843

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

Led by Eli Lilly and Company · Updated on 2026-05-13

460

Participants Needed

45

Research Sites

189 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The main purpose of this study is to evaluate safety and efficacy, and measure how much LY4584180 gets into the bloodstream and how long it takes the body to eliminate it in patients with previously treated blood cancers. For each participant, the study could last about 9 months or possibly longer including screening.

CONDITIONS

Official Title

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Has been treated for the following blood cancers and has received at least 2 prior lines of systemic therapy or is not eligible for available therapy: Diffuse large B-cell lymphoma - not otherwise specified, High-grade B-cell lymphoma, Diffuse large B-cell lymphoma transformed from indolent lymphomas, Follicular large B-cell lymphoma, Follicular lymphoma, Other non-Hodgkin lymphoma
  • Has measurable disease
  • Has discontinued all previous cancer treatments and recovered from immediate effects of therapy
Not Eligible

You will not qualify if you...

  • Has an active second cancer
  • Has known central nervous system involvement by systemic lymphoma unless neurologically stable and without active disease with sponsor approval
  • Has known Cytomegalovirus infection (only negative status eligible)
  • Has known hepatitis B or C infection or uncontrolled HIV
  • Has known significant heart disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 45 locations

1

Mayo Clinic - Scottsdale

Scottsdale, Arizona, United States, 85259

Not Yet Recruiting

2

City of Hope

Duarte, California, United States, 91010

Actively Recruiting

3

University of California, Los Angeles (UCLA) - Medical Center

Los Angeles, California, United States, 90059

Not Yet Recruiting

4

University of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center

San Francisco, California, United States, 94158

Not Yet Recruiting

5

Colorado Blood Cancer Institute

Denver, Colorado, United States, 80218

Actively Recruiting

6

University of Miami - Sylvester Cancer Center

Miami, Florida, United States, 33136

Not Yet Recruiting

7

Florida Cancer Specialists - Sarasota

Sarasota, Florida, United States, 34236

Actively Recruiting

8

Emory University Hospital

Atlanta, Georgia, United States, 30322

Actively Recruiting

9

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

10

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

11

Mayo Clinic - Rochester

Rochester, Minnesota, United States, 55905

Not Yet Recruiting

12

Columbia University

New York, New York, United States, 10032

Not Yet Recruiting

13

University of Rochester

Rochester, New York, United States, 14618

Actively Recruiting

14

The Ohio State University (OSU)

Columbus, Ohio, United States, 43210

Actively Recruiting

15

Oregon Health & Science University (OHSU)

Portland, Oregon, United States, 97239

Not Yet Recruiting

16

Sarah Cannon Research Institute

Nashville, Tennessee, United States, 37203

Actively Recruiting

17

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37212

Not Yet Recruiting

18

Texas Oncology - DFW (Sammons CC)

Dallas, Texas, United States, 75246

Not Yet Recruiting

19

Baylor College of Medicine

Houston, Texas, United States, 77030

Not Yet Recruiting

20

University of Washington - Fred Hutchinson Cancer Center (Seattle Cancer Care Alliance)

Seattle, Washington, United States, 98195

Not Yet Recruiting

21

Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Not Yet Recruiting

22

CHU de Nantes - Hotel-Dieu

Nantes, France, 44093

Not Yet Recruiting

23

Institut Curie

Paris, France, 75005

Not Yet Recruiting

24

CHU Bordeaux - Hopital Haut-Leveque - Centre Francois Magendie

Pessac, France, 33604

Not Yet Recruiting

25

HCL Centre Hospitalier Lyon Sud

Pierre-Bénite, France, 69495

Not Yet Recruiting

26

Oncopole Claudius Regaud

Toulouse, France, 31059

Not Yet Recruiting

27

Charite Universitaetsmedizin Berlin

Berlin, Germany, 10117

Not Yet Recruiting

28

Universitaetsklinikum Koeln (AoeR)

Cologne, Germany, 50937

Not Yet Recruiting

29

Universitaetsklinikum Essen

Essen, Germany, 45147

Not Yet Recruiting

30

Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet

Frankfurt am Main, Germany, 60590

Not Yet Recruiting

31

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola

Bologna, Italy, 40138

Not Yet Recruiting

32

Istituto Europeo di Oncologia

Milan, Italy, 20141

Not Yet Recruiting

33

National Cancer Center Hospital East

Chiba, Japan, 277-8577

Not Yet Recruiting

34

Cancer Institute Hospital of JFCR

Tokyo, Japan, 135-8550

Not Yet Recruiting

35

Pratia Onkologia Katowice

Katowice, Poland, 40-519

Not Yet Recruiting

36

Pratia MCM Krakow

Krakow, Poland, 30-727

Not Yet Recruiting

37

AIDPORT Sp. z o.o.

Skorzewo, Poland, 60-185

Not Yet Recruiting

38

Instytut Hematologii i Transfuzjologii w Warszawie

Warsaw, Poland, 02-776

Not Yet Recruiting

39

Institut Catala d'Oncologia - L'Hospitalet

Barcelona, Spain, 08908

Not Yet Recruiting

40

South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz

Madrid, Spain, 28040

Not Yet Recruiting

41

King's College Hospital

London, United Kingdom, SE5 9RS

Not Yet Recruiting

42

The Royal Marsden NHS Foundation Trust

London, United Kingdom, SW3 6JJ

Not Yet Recruiting

43

Nottingham City Hospital

Nottingham, United Kingdom, NG5 1PB

Not Yet Recruiting

44

Derriford Hospital

Plymouth, United Kingdom, PL6 8DH

Not Yet Recruiting

45

University Hospital Southampton NHS Foundation Trust

Southampton, United Kingdom, SO16 6YD

Not Yet Recruiting

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Research Team

T

Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or

CONTACT

P

Physicians interested in becoming principal investigators please contact

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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