What is magnesium studying for bladder spasms after urologic surgery?

This study is evaluating whether intravenous magnesium can prevent bladder spasms following outpatient urologic procedures. Researchers want to understand if magnesium given during surgery reduces the frequency and severity of these spasms. The trial is sponsored by Mayo Clinic and focuses on improving post-operative care for patients undergoing bladder invasive procedures.

Who may be eligible for this bladder spasms clinical trial?

Adults 18 years or older undergoing bladder invasive procedures at the Mayo Clinic outpatient center may be eligible. Participants must not be pregnant, have allergies to magnesium, or have certain health issues like kidney problems or neuromuscular weakness. Please review eligibility criteria for more details.

Is there any cost to participate in this bladder spasms clinical trial?

Study-related care, including the study drug or procedure and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase 2

Age: 18Years +

All Genders

ID05806996

Intravenous Magnesium to Prevent Bladder Spasms After Outpatient Urologic Surgery A Randomized Placebo-Controlled Study

Led by Mayo Clinic · Updated on 2026-06-29

120

Participants Needed

Research Sites

26 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating whether intravenous magnesium can help prevent bladder spasms after outpatient urologic surgery. This study focuses on patients undergoing bladder invasive procedures, aiming to compare magnesium treatment to a placebo to assess its preventive effects on post-operative bladder spasms. Participants will be randomly assigned to receive either intravenous magnesium or an equivalent volume of normal saline placebo during their urologic surgery. The magnesium is given as a loading dose of 50 mgkg followed by an infusion of 15 mgkghour. The trial uses a parallel design with quadruple masking to compare these treatments. During the study, participants will be monitored post-operatively for about 4 hours to assess the incidence and severity of bladder spasms, the need for treatment of spasms, and patient satisfaction. The primary outcome is the occurrence of bladder spasms approximately 1 hour after surgery. The research team will also track other outcomes at around 4 hours after surgery. The trial spans from July 2023 to December 2026.

CONDITIONS

Brief Title

A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Be undergoing a bladder invasive procedure with or without planned urinary catheter at Mayo Clinic Gonda 7 Outpatient Procedure Center.

You will not qualify if you...

Unable to give informed consent or comply with study procedures.
Allergy or known sensitivity to magnesium or Renacidin.
Expected or high risk of bladder extravasation.
Ongoing atrial fibrillation prior to surgery.
Undergoing emergency surgery.
Pregnant.
Known hypermagnesemia.
Neuromuscular weakness (e.g., Myasthenia gravis).
Myocardial compromise or cardiac conduction defects.
Renal insufficiency with glomerular filtration rate less than 30.
Use of calcium channel blockers due to potential muscle suppression.

Research Team

Tami Krpata

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