Meaning-Centered Psychotherapy for Cancer Caregivers: Study protocol of a randomized controlled trial.
Allison J Applebaum, Leah E Walsh, Talia Zaider...
https://pubmed.ncbi.nlm.nih.gov/41864988/Actively Recruiting
Led by Icahn School of Medicine at Mount Sinai · Updated on 2026-05-26
200
Participants Needed
8
Research Sites
N/A
Total Duration
This research aims to evaluate the effects of Meaning-Centered Psychotherapy for Caregivers MCP-C compared to standard Supportive Psychotherapy for Caregivers SP-C in people caring for patients with advanced cancer. The study focuses on improving caregivers sense of meaning, spiritual well-being, and mental health, addressing common challenges such as caregiver burden, burnout, and stress. It is designed as a randomized behavioral intervention without masking. Participants will be randomly assigned to receive either MCP-C, an innovative, manualized therapy that helps caregivers find meaning and purpose despite caregiving challenges, or SP-C, which represents standard supportive psychotherapy. Both therapies consist of 7 sessions. Questionnaires assessing meaning, spiritual well-being, depression, anxiety, and social support are completed before therapy starts and at approximately 2 weeks, 6 months, and 12 months after the last session. Participants may continue with therapy even if their loved one passes away. During the study, participants complete four sets of questionnaires taking about 35 to 50 minutes each, providing information on their life attitude, spiritual well-being, anxiety, depression, and caregiver experiences. The primary outcomes include improvements on the Life Attitude Profile-Revised and FACIT Spiritual Well-Being Scale over one year. Secondary measures assess anxiety, depression, benefit finding, caregiver reactions, and social support. Participation ends after the last questionnaire unless participants choose otherwise.
CONDITIONS
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
A
Allison Applebaum, PhD, FAPOS
M
Morgan Loschiavo, MPH
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Icahn School of Medicine at Mount Sinai
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | MCP‑C (study intervention) | Supportive Psychotherapy (active comparator) |
|---|---|---|
| What it is | A manualized seven‑session behavioral intervention that helps caregivers of people with advanced cancer connect to meaning and purpose in life | Standard supportive psychotherapy offered to caregivers as active comparator |
| Role in the trial | Experimental therapy arm under investigation | Active comparator therapy arm |
| Primary purpose | Support caregivers’ sense of meaning, spiritual well‑being, and personal meaning | Provide standard supportive psychological care for caregiver distress |
| How it is provided | Delivered as a structured seven‑session manualized behavioral therapy | Delivered as standard supportive psychotherapy sessions |
| External evidence | Pilot trials suggest improvements in meaning, benefit‑finding and spiritual well‑being | Supportive psychotherapy is a commonly used approach to address emotional distress in cancer caregivers |
| Important limitations | Efficacy currently tested; findings not yet confirmed in large trials | Comparator represents standard care but may vary in delivery |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or via telehealth)
Duration - Up to 1 year
Participants receive either Meaning-Centered Psychotherapy or Supportive Psychotherapy to help caregivers connect to meaning and manage caregiving distress.
Weekly sessions for the duration of treatment
Duration - Up to 1 year
Participants are monitored for ongoing well-being and assessment of therapy outcomes after treatment ends.
Periodic assessments depending on therapy schedule
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Allison J Applebaum, Leah E Walsh, Talia Zaider...
https://pubmed.ncbi.nlm.nih.gov/41864988/Allison J J Applebaum, Leah E Walsh, Talia Zaider...
https://pubmed.ncbi.nlm.nih.gov/41674824/Icahn School of Medicine at Mount Sinai
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Collaborating Sponsor