Actively Recruiting
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
Led by Medical College of Wisconsin · Updated on 2026-05-11
20
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit. However, the subjective nature of current intraoperative hand motor assessments do not offer a comprehensive understanding of how hand strength and function may be impacted by resection. Additionally, there is a paucity of data to inform how altering DES parameters may effect motor mapping. Here, the investigators seek to demonstrate a feasible, standardized protocol to quantitatively assess hand strength and function and systematically assess several stimulation parameters to improve intraoperative measurements and better understand how cortical stimulation interacts with underlying neural function.
CONDITIONS
Official Title
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 - 75
- Ability to understand and sign informed consent
- Radiographic evidence of tumor invading primary motor cortex in the non-dominant hemisphere
- Karnofsky performance status 70 or higher
- Normal or near normal motor strength (at least 3/5 in relevant areas)
- Normal or near normal speech (can consistently name at least 4/5 cards)
- Free of other illness that may shorten life expectancy
- Willing and able to participate in all study aspects
You will not qualify if you...
- Presence of other malignancy not in remission
- Evidence of bi-hemispheric or widespread tumor involvement
- Medically high-risk surgical candidate
- History of recent scalp or systemic infection
- Presence of other implants or foreign bodies in the head
- Inability to receive MRI for any reason
- Inability to receive cortical stimulation for any reason
- Presence of implanted cardiac device such as pacemaker or defibrillator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
S
Sarah Cornell
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DEVICE_FEASIBILITY
Number of Arms
1
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