Actively Recruiting
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Led by University Hospital, Tours · Updated on 2025-11-24
40
Participants Needed
3
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute leukemia (AL) is the most common cancer in children. Despite the optimization of chemotherapy treatments and the development of supportive care, a certain number of LAs relapse and/or progress to death of the child. It therefore seems essential to try to better understand the physiopathology and the mechanisms of resistance to treatment of these diseases.
CONDITIONS
Official Title
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child diagnosed with acute lymphoblastic or myeloblastic leukemia at diagnosis
- No prior hematological treatment received
- Aged between 1 and 15 years old
- Both parents or legal guardian have signed informed consent
- Affiliated with or beneficiary of a social security scheme
- For control group: child undergoing orthopedic surgery exposing bone marrow (pelvis osteotomy)
- Control group child aged between 1 and 15 years
- Control group child has no hematological disease
- Control group child has not received treatments affecting bone marrow function
You will not qualify if you...
- Patient under 1 year old or over 15 years old
- Contraindication to myelogram
- Lack of informed consent signed by both parents or legal guardian
- Relapsed acute lymphoblastic or myeloblastic leukemia
- Prior hematological treatments received
- Parents with physical or mental condition preventing understanding of informed consent
- Control group patient with underlying hematological disease
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Service d'hématologie biologique-CHRU TOURS
Tours, France, 37044
Not Yet Recruiting
2
Service d'onco-hématologie pédiatrique -CHRU Tours
Tours, France, 37044
Actively Recruiting
3
Service de chirurgie orthopédique pédiatrique -CHRU TOURS
Tours, France, 37044
Actively Recruiting
Research Team
O
Olivier HERAULT, MD-PhD
CONTACT
W
Wiebe de JONG, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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