What is methylprednisolone studying for patients undergoing hepatectomy?

This trial studies whether a single dose of methylprednisolone given before major liver surgery can reduce side effects like infections and longer hospital stays. Researchers want to know if adding this steroid to standard care improves recovery after hepatectomy. The study is sponsored by Memorial Sloan Kettering Cancer Center.

Who may be eligible for this hepatectomy clinical trial?

Adults 18 years or older scheduled for elective major hepatectomy may be eligible. Participants must not have allergies to methylprednisolone or recent long-term steroid use. Pregnancy and certain kidney problems exclude participation. Please review eligibility criteria for more details.

Is there any cost to participate in this hepatectomy clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for their travel and stay.

Actively Recruiting

Phase 3

Age: 18Years +

All Genders

ID07507643

Testing Methylprednisolone to Reduce Surgery Side Effects in Adults Having Major Liver Surgery

Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-07-07

750

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the use of methylprednisolone before surgery in patients undergoing major liver surgery called hepatectomy. The main goal is to see if methylprednisolone can reduce side effects of surgery, such as infections and longer hospital stays. This is a randomized controlled trial comparing methylprednisolone with the standard care without steroids.

CONDITIONS

Brief Title

A Study of Methylprednisolone in People Having Liver Surgery

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age ≥ 18 years or older at the time of consent
Scheduled to undergo elective major hepatectomy (trisegmentectomy, total left hepatectomy, or total right hepatectomy)
May undergo additional partial hepatectomy or operative ablation alongside major hepatectomy

You will not qualify if you...

Known or documented adverse reactions to methylprednisolone
Unable to receive methylprednisolone due to other medical conditions
Long-term systemic corticosteroid use (10 days or more) within 30 days before surgery, except steroids given with preoperative chemotherapy
Significant chance of unsuccessful surgery due to unresectability
Expected to have major organ resection other than liver
Expected to have biliary tree reconstruction via biliary-enteric anastomosis
Scheduled for insertion of hepatic artery infusion pump device
Renal dysfunction (creatinine clearance ≤40 mL/min or on dialysis)
Dependent on mechanical ventilation before surgery
Pregnant or nursing females
Known bacterial infection expected at surgery or recent systemic antibiotic or antifungal use within 7 days before surgery
Unable to provide informed consent

Research Team

Michael D'Angelica, MD

Peter Kingham, MD

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Testing Methylprednisolone to Reduce Surgery Side Effects in Adults Having Major Liver Surgery

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria