Actively Recruiting
A Study of Methylprednisolone in People Having Liver Surgery
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-02
750
Participants Needed
19
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to test whether receiving methylprednisolone before surgery will reduce the side effects of having surgery, such as infections and longer hospital stays.
CONDITIONS
Official Title
A Study of Methylprednisolone in People Having Liver Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60;18 years at the time of consent.
- Scheduled to undergo elective major hepatectomy (trisegmentectomy, total left hepatectomy, or total right hepatectomy).
- May also undergo additional partial hepatectomy or operative ablation alongside major hepatectomy.
You will not qualify if you...
- Known or documented adverse reactions to methylprednisolone.
- Unable to receive methylprednisolone due to other medical conditions.
- Long-term (10-day or more) systemic corticosteroid use within 30 days before surgery, except for standard preoperative chemotherapy steroids.
- High chance of not completing surgery due to unresectability.
- Expected to have major organ resection or biliary tree reconstruction during surgery.
- Scheduled for concurrent hepatic artery infusion pump device insertion.
- Renal dysfunction with creatinine clearance below 40 mL/min, or on dialysis.
- Dependent on mechanical ventilation before surgery.
- Pregnant or nursing.
- Known bacterial infection expected at surgery or recent systemic antibiotic/antifungal therapy within 7 days before surgery.
- Unable to provide informed consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
Rush University Medical Center (Data collection only)
Chicago, Illinois, United States, 606012
Not Yet Recruiting
2
University of Chicago (Data Collection Only)
Chicago, Illinois, United States, 60637
Not Yet Recruiting
3
Indiana University (Data Collection Only)
Indianapolis, Indiana, United States, 46202
Not Yet Recruiting
4
UNIVERSITY OF IOWA (Data Collection Only)
Iowa City, Iowa, United States, 52242
Not Yet Recruiting
5
University of Kentucky (Data Collection Only)
Lexington, Kentucky, United States, 40536-0093
Not Yet Recruiting
6
Henry Ford Hospital (Data collection only)
Detroit, Michigan, United States, 48202
Not Yet Recruiting
7
Mayo Clinic (Data Collection Only)
Rochester, Minnesota, United States, 55905
Not Yet Recruiting
8
Washington University (Data Collection Only)
St Louis, Missouri, United States, 63110
Not Yet Recruiting
9
University of Nebraska Medical Center (Data Collection Only)
Omaha, Nebraska, United States, 68198-7680
Not Yet Recruiting
10
Rutgers University (Data Collection Only)
New Brunswick, New Jersey, United States, 08903
Not Yet Recruiting
11
Memorial Sloan Kettering Commack (Data Collection Only)
Commack, New York, United States, 11725
Actively Recruiting
12
Memoral Sloan Kettering Westchester (Data Collection Only)
Harrison, New York, United States, 10604
Actively Recruiting
13
Northwell Health (Data collection only)
Manhasset, New York, United States, 11030
Not Yet Recruiting
14
New York University (Data Collection Only)
New York, New York, United States, 10010
Not Yet Recruiting
15
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
16
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Not Yet Recruiting
17
Duke University (Data Collection Only)
Durham, North Carolina, United States, 27710
Not Yet Recruiting
18
Gundersen Lutheran Medical Foundation (Data Collection Only)
La Crosse, Wisconsin, United States, 54601
Not Yet Recruiting
19
University of Wisconsin (Data Collection Only)
Madison, Wisconsin, United States, 53792
Not Yet Recruiting
Research Team
M
Michael D'Angelica, MD
CONTACT
P
Peter Kingham, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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