Actively Recruiting
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
Led by Pfizer · Updated on 2026-05-05
453
Participants Needed
82
Research Sites
585 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed/ Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study consists of 3 parts; Part 1 and 2 enrolled participants with SCLC, metastatic CRPC, and FL are closed for enrollment. Part 3, which is open for enrollment is seeking men who: * have Castration Resistant Prostate Cancer (CRPC) and * have previously received treatment for CRPC and have progressed from the last treatment All participants in Part 3 of this study will receive mevrometostat and/ or enzalutamide. Part 3 consists of 2 sub studies each has an assessment phase and a maintenance phase. The Part 3 DDI substudy consist of 2 cohorts, Cohort 1 (monotherapy cohort) and Cohort 2 (Combination cohort). In the assessment phase: * participants in the BE substudy will take 3 single doses of mevrometostat by mouth over 3 periods. * participants in the DDI substudy Cohort 1 (monotherapy cohort) will take mevrometostat 2 times a day and/or itraconazole 1 time a day based on a present schedule. * participants in the DDI substudy Cohort 2 (combination cohort) will take mevrometostat 2 times a day, enzalutamide 1 time a day, and/or itraconazole 1 time a day based on a present schedule. After completion of the assessment phase, participants will enter the maintenance phase where they will receive mevrometostat 2 times a day and enzalutamide 1 time a day by mouth until their cancer is no longer responding. The study will look at the experiences of participanrs receiving the study medicine. This will help see if the study medicine is safe and effective.
CONDITIONS
Official Title
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological or cytological diagnosis of castration resistant prostate cancer
- Eastern Cooperative Oncology Group Performance Status of 0 to 2
- Expected life expectancy of at least 6 months
- Adequate bone marrow, kidney, and liver function
- Age 18 years or older
You will not qualify if you...
- Prior radiation to more than 25% of bone marrow
- QTcF interval greater than 480 milliseconds at screening
- Uncontrolled high blood pressure above 150/90 mmHg despite medication
- Known or suspected allergy to Mevrometostat or enzalutamide
- Active inflammatory gastrointestinal disease, chronic diarrhea, diverticular disease, or past gastric surgery
- Current or expected use of strong or moderate CYP3A4/5 inducers or inhibitors
- Use of enzalutamide within the last 4 weeks
- History of congestive heart failure or ventricular dysfunction (for DDI substudy)
- Fructose intolerance (for DDI substudy)
- Use of CYP3A4 substrates (for DDI substudy)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 82 locations
1
Banner-University Medical Center Tucson
Tucson, Arizona, United States, 85719
Active, Not Recruiting
2
The University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States, 85719
Active, Not Recruiting
3
The University of Arizona Cancer Center
Tucson, Arizona, United States, 85724
Active, Not Recruiting
4
Arizona Urology Specialists, PLLC
Tucson, Arizona, United States, 85741
Terminated
5
Pacific Cancer Medical Center INC
Anaheim, California, United States, 92801
Active, Not Recruiting
6
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, California, United States, 91010
Active, Not Recruiting
7
City of Hope Investigational Drug Services (IDS)
Duarte, California, United States, 91010
Active, Not Recruiting
8
Norwalk Hospital
Norwalk, Connecticut, United States, 06856
Active, Not Recruiting
9
The University of Kansas Cancer Center, Investigational Drug Services
Fairway, Kansas, United States, 66205
Active, Not Recruiting
10
The University of Kansas Clinical Research Center
Fairway, Kansas, United States, 66205
Active, Not Recruiting
11
The University of Kansas Hospital
Kansas City, Kansas, United States, 66160
Active, Not Recruiting
12
The University of Kansas Medical Center Medical Office Building
Kansas City, Kansas, United States, 66160
Active, Not Recruiting
13
The University of Kansas Cancer Center - Indian Creek Campus
Overland Park, Kansas, United States, 66211
Active, Not Recruiting
14
The University of Kansas Cancer Center
Westwood, Kansas, United States, 66205
Active, Not Recruiting
15
Norton Cancer Institute Pharmacy, Downtown Pharmacy
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
16
Norton Cancer Institute Pharmacy
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
17
Norton Cancer Institute, Norton Healthcare Pavilion
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
18
Norton Hospital
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
19
Maryland Oncology Hematology, P.A.
Rockville, Maryland, United States, 20850
Terminated
20
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Active, Not Recruiting
21
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Active, Not Recruiting
22
Dana Farber Cancer Institute- Chestnut Hill
Newton, Massachusetts, United States, 02459
Active, Not Recruiting
23
Oncology Hematology West, PC dba Nebraska Cancer Specialists
Omaha, Nebraska, United States, 68130
Actively Recruiting
24
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Active, Not Recruiting
25
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Active, Not Recruiting
26
OU Health University of Oklahoma Medical Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
27
Stephenson Cancer Center (chemo location)
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
28
Carolina Urologic Research Center
Myrtle Beach, South Carolina, United States, 29572
Actively Recruiting
29
Parkway Surgery Center
Myrtle Beach, South Carolina, United States, 29572
Actively Recruiting
30
Sarah Cannon Research Institute - Pharmacy
Nashville, Tennessee, United States, 37203
Actively Recruiting
31
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
32
Texas Oncology - Austin Midtown
Austin, Texas, United States, 78705
Terminated
33
University of Texas Southwestern Medical Center - Simmons Cancer Center
Dallas, Texas, United States, 75390
Active, Not Recruiting
34
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Active, Not Recruiting
35
UT Southwestern University Hospital - William P. Clements, Jr
Dallas, Texas, United States, 75390
Active, Not Recruiting
36
UT Southwestern University Hospital - Zale Lipshy
Dallas, Texas, United States, 75390
Active, Not Recruiting
37
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States, 75063
Terminated
38
US Oncology Investigational Products Center
Irving, Texas, United States, 75063
Terminated
39
NEXT Oncology
San Antonio, Texas, United States, 78229
Not Yet Recruiting
40
NEXT Oncology
San Antonio, Texas, United States, 78240
Active, Not Recruiting
41
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States, 22031
Active, Not Recruiting
42
Olympic Medical Center
Port Angeles, Washington, United States, 98362
Actively Recruiting
43
Fred Hutchinson Cancer Center Alliance Peninsula
Poulsbo, Washington, United States, 98370
Actively Recruiting
44
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
45
University of Washington Medical Center
Seattle, Washington, United States, 98109
Actively Recruiting
46
Specialized Hospital for Active Treatment of Oncology - Haskovo
Haskovo, Bulgaria, 6300
Terminated
47
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China, 510120
Active, Not Recruiting
48
Hunan Cancer Hospital
Changsha, Hunan, China, 410013
Actively Recruiting
49
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China, 210008
Actively Recruiting
50
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
51
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
52
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Active, Not Recruiting
53
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Active, Not Recruiting
54
Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
Koszalin, Poland, 75-581
Active, Not Recruiting
55
Centrum Medyczne MEDYK
Rzeszów, Poland, 35-326
Active, Not Recruiting
56
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, Poland, 02-781
Active, Not Recruiting
57
Private Medical Institution "Euromedservice"
Pushkin, Sankt-Peterburg, Russia, 196603
Active, Not Recruiting
58
LLC "Neyro-klinika"
Moscow, Russia, 117186
Active, Not Recruiting
59
Moscow GBUZ "City clinical hospital n. a. S.P. Botkina" of Moscow health department
Moscow, Russia, 125284
Terminated
60
SBHI of Moscow City Clinical Hospital
Moscow, Russia, 129301
Terminated
61
Budgetary Healthcare Institution of Omsk region "Clinical Oncological Dispensary"
Omsk, Russia, 644013
Terminated
62
Federal State Budgetary Institution National Medical Research Center n.a. V.A. Almazov
Saint Petersburg, Russia, 197341
Terminated
63
Federal State Budgetary Institution National Medical Research Center for Oncology n.a. N.N.
Saint Petersburg, Russia, 197758
Terminated
64
Saint Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"
Saint Petersburg, Russia, 198255
Terminated
65
State Budgetary Healthcare Institution of the Yaroslavl Region
Yaroslavl, Russia, 150054
Terminated
66
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea, 13620
Actively Recruiting
67
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03080
Active, Not Recruiting
68
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722
Terminated
69
Ewha Womans University Mokdong Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 07985
Active, Not Recruiting
70
Chungnam national university hospital
Daejeon, Taejǒn-kwangyǒkshi, South Korea, 35015
Active, Not Recruiting
71
Institut Català d´Oncología (ICO)-H. Durán i Reynals
L'Hospitalet de Llobregat, Barecelona, Spain, 08908
Actively Recruiting
72
Consorcio Hospitalario Provincial de Castellon
Castellon, Castellon, Spain, 12002
Active, Not Recruiting
73
Hospital Quironsalud Madrid
Pozuelo de Alarcón, Madrid, Spain, 28223
Actively Recruiting
74
Hospital Quironsalud Barcelona
Barcelona, Spain, 08023
Actively Recruiting
75
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
76
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
77
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
78
H.U. Fundación Jiménez Díaz
Madrid, Spain, 28040
Actively Recruiting
79
Hospital Universitario 12 De Octubre
Madrid, Spain, 28041
Actively Recruiting
80
Hospital Universitario HM Sanchinarro
Madrid, Spain, 28050
Actively Recruiting
81
Hospital Universitario Virgen de la Victoria
Málaga, Spain, 29010
Actively Recruiting
82
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
10
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