Actively Recruiting
A Study of Mirikizumab Solution (LY3074828) in Healthy Participants
Led by Eli Lilly and Company · Updated on 2026-05-14
450
Participants Needed
5
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to assess the safety and tolerability of mirikizumab (LY3074828) solution formulation administered as a single injection compared with two injections under the skin in healthy participants. Blood tests will be performed to investigate how the body processes the study drug. For each participant, the study will last about 15 weeks.
CONDITIONS
Official Title
A Study of Mirikizumab Solution (LY3074828) in Healthy Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be a healthy male or female as confirmed by medical history, physical exam, lab tests, ECG, and vital signs
- Have normal lab test results at screening and the day before dosing
- Have a body mass index between 18.0 and 34.0 kg/m2 inclusive
You will not qualify if you...
- Have significant allergies to humanized monoclonal antibodies, mirikizumab, related compounds, or components of the formulation, or a history of major atopy
- Have serious past or current conditions that could affect drug absorption, metabolism, or elimination
- Have severe drug allergies, intolerance to topical corticosteroids, or severe hypersensitivity reactions
- Are immunocompromised
- Plan to use any medications, including herbal or traditional medicines, within 7 days before dosing
- Have received biologic agents within 3 months or 5 half-lives before dosing
- Have previously been treated with mirikizumab
- Have abnormal 12-lead ECG findings
- Have significant abnormalities in blood pressure, pulse, or body temperature
- Have a current or recent active infection
- Have active tuberculosis or a history of active tuberculosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States, 32117
Actively Recruiting
2
Axis Clinicals LLC
Dilworth, Minnesota, United States, 56529
Actively Recruiting
3
Fortrea Clinical Research Unit
Dallas, Texas, United States, 75247
Actively Recruiting
4
Worldwide Clinical Trials, Inc.
San Antonio, Texas, United States, 78217
Actively Recruiting
5
Fortrea Clinical Research Unit
Madison, Wisconsin, United States, 53704
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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