Actively Recruiting
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-13
250
Participants Needed
55
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each cancer type in this study. The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.
CONDITIONS
Official Title
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For Cohort A: Diagnosed with hormone receptor positive/HER2-negative invasive breast cancer that is locally advanced or metastatic and not curable by surgery
- For Cohort A: Experienced disease progression after at least one prior endocrine therapy in metastatic setting
- For Cohort B: Histologically confirmed high-grade epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
- For Cohort B: Received 4 to 8 cycles of platinum-based chemotherapy in third-line setting for ovarian cancer
- For Cohort C: Diagnosed with low-grade endometrioid carcinoma, either primary advanced or recurrent
- For Cohort C: Treatment naive or received up to one prior line of platinum-based therapy
- All cohorts: Recovered to Grade 1 or baseline from side effects of previous anticancer therapies
- All cohorts: HIV-infected participants must have well-controlled HIV on antiretroviral therapy
- All cohorts: Participants with Hepatitis B or C must have undetectable viral load after treatment
You will not qualify if you...
- For Cohort A: Breast cancer that can be treated with curative intent
- For Cohort A: Advanced symptomatic visceral spread with life-threatening risks
- For Cohort B: Nonepithelial cancers, borderline tumors, low-grade serous or endometrioid cancers, and other specified ovarian cancer types
- For Cohort B: Platinum-resistant or refractory ovarian cancer
- For Cohort B: Candidates for curative surgery or radiotherapy for ovarian cancer
- For Cohort C: High-grade or nonendometrioid carcinoma and other specified uterine tumors
- For Cohort C: Candidates for curative surgery or radiotherapy
- All cohorts: Confirmed or suspected adrenal metastases
- All cohorts: Difficulty swallowing oral medications or conditions impairing absorption
- All cohorts: History or current adrenal insufficiency
- All cohorts: HIV with history of Kaposi's sarcoma or Multicentric Castleman's Disease
- All cohorts: Received live vaccine within 30 days before study intervention
- All cohorts: Additional progressing malignancy requiring treatment within past 3 years
- All cohorts: Active central nervous system metastases or carcinomatous meningitis
- All cohorts: History of stem cell or solid organ transplant
- All cohorts: Not recovered from major surgery or ongoing surgical complications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 55 locations
1
Alaska Womens Cancer Care ( Site 0037)
Anchorage, Alaska, United States, 99508
Actively Recruiting
2
Mount Sinai Cancer Center ( Site 0009)
Miami Beach, Florida, United States, 33140
Actively Recruiting
3
TRIALS 365 ( Site 0022)
Shreveport, Louisiana, United States, 71103
Actively Recruiting
4
Mary Lanning Healthcare ( Site 0019)
Hastings, Nebraska, United States, 68901
Actively Recruiting
5
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0021)
Hackensack, New Jersey, United States, 07601
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center ( Site 0002)
New York, New York, United States, 10065
Actively Recruiting
7
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0008)
Columbus, Ohio, United States, 43210
Actively Recruiting
8
Baylor College of Medicine Medical Center ( Site 0004)
Houston, Texas, United States, 77030
Actively Recruiting
9
Mays Cancer Center ( Site 0039)
San Antonio, Texas, United States, 78229
Actively Recruiting
10
Hospital Aleman ( Site 0301)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1118AAT
Actively Recruiting
11
Centro Medico Dr. Doreski - Fundación Respirar ( Site 0302)
Buenos Aires, Buenos Aires F.D., Argentina, C1118AAT
Actively Recruiting
12
Instituto Alexander Fleming ( Site 0303)
Buenos Aires, Buenos Aires F.D., Argentina, C1426ANZ
Actively Recruiting
13
Hospital Santa Rita de Cassia ( Site 3104)
Vitória, Espírito Santo, Brazil, 29043-260
Actively Recruiting
14
Obras Sociais Irma Dulce ( Site 3112)
Salvador, Estado de Bahia, Brazil, 41680-430
Actively Recruiting
15
Hospital Felicio Rocho ( Site 3105)
Belo Horizonte, Minas Gerais, Brazil, 30110-934
Actively Recruiting
16
Hospital de Cancer de Pernambuco ( Site 3103)
Recife, Pernambuco, Brazil, 50040-000
Actively Recruiting
17
Liga Norte Riograndense Contra o Cancer ( Site 3108)
Natal, Rio Grande do Norte, Brazil, 59062-000
Actively Recruiting
18
Instituto Nacional de Câncer - INCA ( Site 3107)
Rio de Janeiro, Brazil, 20230-130
Actively Recruiting
19
Princess Margaret Cancer Centre ( Site 0202)
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
20
FALP ( Site 3300)
Santiago, Region M. de Santiago, Chile, 7500921
Actively Recruiting
21
Pontificia Universidad Catolica de Chile ( Site 3307)
Santiago, Region M. de Santiago, Chile, 8330032
Actively Recruiting
22
Bradfordhill ( Site 3301)
Santiago, Region M. de Santiago, Chile, 8420383
Actively Recruiting
23
ONCOCENTRO APYS ( Site 3302)
Viña del Mar, Valparaiso, Chile, 2520598
Actively Recruiting
24
Sarawak General Hospital ( Site 0602)
Kuching, Sarawak, Malaysia, 93586
Actively Recruiting
25
Pantai Hospital Kuala Lumpur ( Site 0603)
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
26
University Malaya Medical Centre ( Site 0601)
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
27
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 3405)
Concepción, Departamento de Junín, Peru, 12125
Actively Recruiting
28
Clínica San Antonio ( Site 3404)
Trujillo, La Libertad, Peru, 13008
Actively Recruiting
29
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3400)
Lima, Peru, 15036
Actively Recruiting
30
Instituto Nacional de Enfermedades Neoplásicas ( Site 3401)
Lima, Peru, 15038
Actively Recruiting
31
National Cancer Centre Singapore ( Site 0800)
Singapore, Central Singapore, Singapore, 168583
Actively Recruiting
32
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2000)
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
33
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2003)
A Coruña, La Coruna, Spain, 15006
Actively Recruiting
34
Clinica Universitaria Navarra - Madrid ( Site 2004)
Madrid, Madrid, Comunidad de, Spain, 28027
Actively Recruiting
35
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2002)
Madrid, Madrid, Comunidad de, Spain, 28034
Actively Recruiting
36
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2001)
Madrid, Spain, 28223
Actively Recruiting
37
Taichung Veterans General Hospital ( Site 1004)
Taichung, Taiwan, 407
Actively Recruiting
38
National Cheng Kung University Hospital ( Site 1003)
Tainan, Taiwan, 704
Actively Recruiting
39
Mackay Memorial Hospital ( Site 1002)
Taipei, Taiwan, 10449
Actively Recruiting
40
Chulalongkorn Hospital ( Site 1114)
Bangkok, Bangkok, Thailand, 10330
Actively Recruiting
41
Faculty of Medicine Siriraj Hospital ( Site 1111)
Bangkok, Bangkok, Thailand, 10700
Actively Recruiting
42
Songklanagarind Hospital ( Site 1113)
Songkhla, Thailand, 90110
Actively Recruiting
43
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2201)
Adana, Turkey (Türkiye), 01240
Actively Recruiting
44
Hacettepe Universitesi ( Site 2200)
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
45
Trakya Üniversitesi Eğitim Araştırma Hastanesi ( Site 2204)
Edirne, Turkey (Türkiye), 22030
Actively Recruiting
46
Istanbul Universitesi Cerrahpasa ( Site 2203)
Istanbul, Turkey (Türkiye), 34098
Actively Recruiting
47
Koc University, School of Medicine ( Site 2202)
Istanbul, Turkey (Türkiye), 34450
Actively Recruiting
48
University Hospitals Sussex NHS Foundation Trust ( Site 2301)
East Sussex, Brighton And Hove, United Kingdom, BN2 1ES
Actively Recruiting
49
The Royal Cornwall Hospital ( Site 2306)
Truro, Cornwall, United Kingdom, TR1 3LJ
Actively Recruiting
50
St Bartholomew's Hospital ( Site 2302)
London, London, City of, United Kingdom, EC1A 7BE
Actively Recruiting
51
University College Hospital London ( Site 2303)
London, London, City of, United Kingdom, NW1 2PG
Actively Recruiting
52
Guy's & St Thomas' NHS Foundation Trust ( Site 2309)
London, London, City of, United Kingdom, SE1 9RT
Actively Recruiting
53
Western General Hospital ( Site 2307)
Edinburgh, Midlothian, United Kingdom, EH4 2XU
Actively Recruiting
54
Queen Elizabeth Hospital ( Site 2305)
Birmingham, United Kingdom, B15 2GW
Actively Recruiting
55
The Christie NHS Foundation Trust ( Site 2300)
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here