Actively Recruiting
Mobility Outcomes in Post-Pulmonary Embolic Disease (MOPED): A Pilot Feasibility Randomized Trial of Home-Based Exercise Training
Led by Mayo Clinic · Updated on 2025-08-05
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new way to deliver home-based exercise for people who have had a pulmonary embolism, a condition where blood clots block blood flow in the lungs. This study aims to use the combined expertise of heart specialists and exercise physiologists to create an interactive care plan that supports patients in their recovery. The trial is a pilot feasibility randomized study that focuses on improving mobility outcomes in this patient group. Participants will be randomly assigned to either a home-based exercise training group or a standard therapy group. Those in the exercise group are recommended to exercise three times a week for 20 minutes per session over 12 weeks. The exercise program is personalized based on a consultation with a clinical exercise physiologist. The standard therapy group will receive usual care without the added exercise intervention. During the study, participants will have their physical capacity assessed at the start, 3 months, and 6 months. Researchers will also track changes in quality of life specific to pulmonary embolism and general health, as well as the number of steps taken by each participant over time. Follow-up visits at baseline, 3 months, and 6 months will help monitor progress and collect the necessary data. The total study duration extends up to 6 months for each participant.
CONDITIONS
Brief Title
A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Diagnosed with acute intermediate-risk pulmonary embolism confirmed by imaging and evidence of right ventricular enlargement or dysfunction
- Diagnosed with acute high-risk pulmonary embolism confirmed by imaging, right ventricular enlargement or dysfunction, and signs of hypotension or cardiogenic shock due to PE
- Able to ambulate independently without assistance
- Able to read and understand English to complete questionnaires
- Willing and able to attend baseline, 3-month, and 6-month follow-up visits
- Able and willing to provide informed written consent
You will not qualify if you...
- Inability to walk independently
- Prior history of pulmonary embolism
- History of chronic thromboembolic pulmonary hypertension or pulmonary arterial hypertension
- Unable to read a questionnaire in English
- Unable to attend baseline, 3-month, or 6-month follow-up visits
- Pulmonary embolism associated with pregnancy
- Life expectancy less than 1 year due to other health conditions
- Unable or unwilling to provide informed written consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants randomized to home-based exercise training will perform exercises 3 days per week, 20 minutes per session, for 12 weeks with a personalized program determined by a clinical exercise physiologist. Participants in standard therapy will continue usual care without additional exercise intervention.
1 baseline visit and 2 follow-up visits at 3 and 6 months
Trial Site Locations
Total: 1 location
1
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
S
Stan Henkin, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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