Actively Recruiting
A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-06
10
Participants Needed
7
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The researchers are doing this study to see how well multiparametric ultrasound (mpUS) imaging can evaluate vaginal tissue before and after IVRT. IVRT is routinely used to treat endometrial cancer but can cause damage to the vaginal tissue (vaginal toxicity). Side effects of vaginal toxicity can include vaginal dryness, itching, soreness, discharge, narrowing or shortening of the vagina (stenosis), and vaginal fibrosis (hardening), which can affect sexual function. The researchers will also look at whether participants are able to complete (tolerate) all mpUS imaging for this study.
CONDITIONS
Official Title
A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with a primary endometrial carcinoma including eligible histologic subtypes
- Initial surgery included hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node assessment
- Complete surgical resection with negative margins and no residual gross disease after surgery
- FIGO (2009) stage I or II disease confirmed by surgical staging
- Age 18 years or older
- Able to start radiotherapy within 12 weeks from surgery date
You will not qualify if you...
- Receiving chemotherapy or hormonal therapy
- Prior or concurrent malignancy that could interfere with IVRT toxicity or efficacy assessment
- Prior pelvic radiotherapy
- Active genitourinary infection requiring antibiotics, except uncomplicated urinary tract infection
- History of active inflammatory bowel disease requiring treatment, including Crohn's disease or ulcerative colitis
- Medical or psychiatric conditions making the participant unsuitable for study enrollment per investigator judgement
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Consent Only)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Consent Only)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
K
Kaled Alektiar, MD
CONTACT
M
Mark Burgess, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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