Actively Recruiting
Study of Myasthenic Crisis in China
Led by Huashan Hospital · Updated on 2023-09-21
300
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter, prospective, observational research. It will register the basic demographic information, medical history characteristics, clinical features, auxiliary examinations, treatment, outcomes of tracheal intubation/ventilator related events, and clinical outcomes of Myasthenic Crisis patients. The objectives including: 1. Obtain epidemiological data of MC in China; 2. Establish a standardized registration system for MC patients in China; 3. Explore the epidemiology, clinical characteristics, serological characteristics, clinical characteristics of MC, predisposing and predictive factors, extubation process/time, weaning/extubation outcome and predictors of clinical outcome in Chinese MC patients.
CONDITIONS
Official Title
Study of Myasthenic Crisis in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical history and signs of fluctuating weakness and fatigability
- Positive test for AChR or MuSK antibodies
- If antibody tests are negative, positive low-frequency repetitive nerve stimulation (2-5Hz) is required
- Crisis defined as rapid worsening of MG requiring intubation or noninvasive ventilation
- Impending crisis defined as rapid worsening with blood gases showing hypoxia (oxygen saturation <95%) or elevated carbon dioxide (PaCO2 >50 mmHg)
You will not qualify if you...
- Repetitive nerve stimulation showing over 100% increase after high-frequency stimulation or R2 repeats to rule out Lambert-Eaton syndrome or congenital MG
- Use of intubation or noninvasive ventilation only during routine postoperative management
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Huashan Hospital Fudan University
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
Research Team
X
Xiao Huan, MD
CONTACT
S
Susan Luo, MD;PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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