Actively Recruiting
A Study of Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer
Led by Qilu Pharmaceutical Co., Ltd. · Updated on 2025-12-18
363
Participants Needed
1
Research Sites
311 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the efficacy of neoadjuvant QL1706 in participants with untreated T4N0 or Stage III (resectable), microsatellite instability high/ defective mismatch repair (MSI-H/dMMR) colon cancer
CONDITIONS
Official Title
A Study of Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent
- Eastern Cooperative Oncology Group Performance Status of 0 or 1
- Untreated pathologically confirmed colon adenocarcinoma
- Radiographic assessment showing resectable stage IIB-III (cT4 or cN+ only) based on AJCC Stage VIII
- Tumor demonstrating microsatellite instability-high or defective mismatch repair (MSI-H/dMMR)
- Adequate organ function as described in the protocol
You will not qualify if you...
- Previously received any antitumor therapy for the disease under study, including surgery, radiotherapy, chemotherapy, targeted therapy, or immunotherapy
- Presence of distant metastatic disease
- Active autoimmune disease requiring systemic treatment in the past 2 years
- Known history of or evidence of interstitial lung disease
- Active infection requiring systemic therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Affiliated Cancer Hospital of Sun Yat-sen University
Guangzhou, China
Actively Recruiting
Research Team
R
Ruihua Xu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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