Actively Recruiting
A Study of Niacin Regulation
Led by Mayo Clinic · Updated on 2026-04-13
32
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adults who gain most of their excess weight in the abdominal area typically do not respond to things that "turn off" fat cells the same way as lean people. The researchers are trying to understand why fat tissue responds differently in people with different body types.
CONDITIONS
Official Title
A Study of Niacin Regulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females between 18 and 65 years old who can understand instructions, follow study procedures, and sign consent
- Agree to eat an isoenergetic diet with all meals from Mayo Clinic for at least 3 days before the study
- Overweight or obese with a BMI of 29.0 to 40.0 kg/m2
- Upper body or visceral obesity defined by waist-hip ratio, visceral fat measurements, or metabolic syndrome markers
- Women not pregnant or nursing, with negative pregnancy tests at screening and within 48 hours before study drug administration
- Women of childbearing potential must use effective contraception during the study
- No recent participation in other investigational drug studies within 12 weeks or five half-lives of the drug
- Total blood drawn in this and other studies does not exceed 450 ml within 8 weeks
- Laboratory values within specified ranges: HbA1C below 6.5% (non-diabetic), fasting glucose below 126 mg/dL, hemoglobin at least 11.0 for women and 12.0 for men, platelets above 100,000
You will not qualify if you...
- History of ischemic heart disease or atherosclerotic valvular disease
- Persistent high blood pressure over 160/95 mmHg despite medication
- Current smokers
- Use of medications affecting fatty acid metabolism such as high-dose fish oil, statins, niacin, fibrates, thiazolidinediones, beta-blockers, corticosteroids, anabolic steroids, pioglitazone, or atypical antipsychotics
- Allergies to lidocaine, Niaspan (confirmed by testing), or indocyanine green
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55904
Actively Recruiting
Research Team
P
Pamela Reich
CONTACT
K
Kelli Lytle, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here