Actively Recruiting
Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation
Led by Case Comprehensive Cancer Center · Updated on 2026-05-07
20
Participants Needed
1
Research Sites
328 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIAGEN (the study drug) is a type of vitamin B supplement that the general public can get without a prescription and is well tolerated.
CONDITIONS
Official Title
Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All disease indications for allogeneic hematopoietic cell transplantation except myelofibrosis
- Must meet program eligibility for myeloablative conditioning alloHCT and plan to undergo myeloablative conditioning
- Have an HLA-identical related donor or unrelated human donor with a bone marrow graft
- Provide written informed consent
You will not qualify if you...
- History of allergy or intolerance to NR precursor compounds, including niacin or nicotinamide
- Pregnant or breastfeeding women
- Uncontrolled intercurrent illness or psychiatric/social conditions limiting compliance with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
R
Ronald Sobecks, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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